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Article: Lymphocyte subsets in patients with oestrogen deficiency

TitleLymphocyte subsets in patients with oestrogen deficiency
Authors
Issue Date1991
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jri
Citation
Journal Of Reproductive Immunology, 1991, v. 20 n. 1, p. 85-91 How to Cite?
AbstractWe have previously shown that in patients with idiopathic premature ovarian failure there were significant changes in lymphocyte subsets. To test our hypothesis that these changes were due to oestrogen deficiency we studied lymphocyte subsets in patients with oestrogen deficiency due to other causes. Blood was taken for serum oestradiol, lymphocyte counts and lymphocyte subset counts (CD2+, CD4+, CD8+ and B cells) before oestrogen replacement in 19 patients with gonadal dysgenesis, 22 patients with hypothalamic-pituitary failure and 24 healthy female control subjects. The CD4:CD8 ratio in both groups of patients was significantly lower than that in the normal control subjects while the percentages and counts of lymphocytes and CD8+ cells were significantly higher. There was a significant positive correlation between the serum oestradiol level and the CD4:CD8 ratio. These findings support the hypothesis that the changes in lymphocyte subsets are due to oestrogen deficiency.
Persistent Identifierhttp://hdl.handle.net/10722/173173
ISSN
2015 Impact Factor: 3.202
2015 SCImago Journal Rankings: 1.233
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, PCen_US
dc.contributor.authorTang, GWKen_US
dc.contributor.authorLawton, JWMen_US
dc.date.accessioned2012-10-30T06:28:20Z-
dc.date.available2012-10-30T06:28:20Z-
dc.date.issued1991en_US
dc.identifier.citationJournal Of Reproductive Immunology, 1991, v. 20 n. 1, p. 85-91en_US
dc.identifier.issn0165-0378en_US
dc.identifier.urihttp://hdl.handle.net/10722/173173-
dc.description.abstractWe have previously shown that in patients with idiopathic premature ovarian failure there were significant changes in lymphocyte subsets. To test our hypothesis that these changes were due to oestrogen deficiency we studied lymphocyte subsets in patients with oestrogen deficiency due to other causes. Blood was taken for serum oestradiol, lymphocyte counts and lymphocyte subset counts (CD2+, CD4+, CD8+ and B cells) before oestrogen replacement in 19 patients with gonadal dysgenesis, 22 patients with hypothalamic-pituitary failure and 24 healthy female control subjects. The CD4:CD8 ratio in both groups of patients was significantly lower than that in the normal control subjects while the percentages and counts of lymphocytes and CD8+ cells were significantly higher. There was a significant positive correlation between the serum oestradiol level and the CD4:CD8 ratio. These findings support the hypothesis that the changes in lymphocyte subsets are due to oestrogen deficiency.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jrien_US
dc.relation.ispartofJournal of Reproductive Immunologyen_US
dc.subject.meshAntigens, Cd - Analysisen_US
dc.subject.meshAntigens, Cd4 - Analysisen_US
dc.subject.meshAutoimmune Diseases - Etiologyen_US
dc.subject.meshB-Lymphocyte Subsets - Immunologyen_US
dc.subject.meshCell Counten_US
dc.subject.meshEstrogens - Deficiencyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGonadal Dysgenesis - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshOvarian Diseases - Immunology - Metabolismen_US
dc.subject.meshT-Lymphocyte Subsets - Immunologyen_US
dc.titleLymphocyte subsets in patients with oestrogen deficiencyen_US
dc.typeArticleen_US
dc.identifier.emailHo, PC:pcho@hku.hken_US
dc.identifier.emailTang, GWK:gwktang@hkucc.hku.hken_US
dc.identifier.authorityHo, PC=rp00325en_US
dc.identifier.authorityTang, GWK=rp00328en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0165-0378(91)90025-Len_US
dc.identifier.pmid1875330-
dc.identifier.scopuseid_2-s2.0-0025809545en_US
dc.identifier.volume20en_US
dc.identifier.issue1en_US
dc.identifier.spage85en_US
dc.identifier.epage91en_US
dc.identifier.isiWOS:A1991FR67100007-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridHo, PC=7402211440en_US
dc.identifier.scopusauthoridTang, GWK=7401633864en_US
dc.identifier.scopusauthoridLawton, JWM=7102180792en_US

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