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Article: Role of CA125 and abdominal pelvic computerized axial tomogram in the monitoring of chemotherapy treatment of ovarian cancer

TitleRole of CA125 and abdominal pelvic computerized axial tomogram in the monitoring of chemotherapy treatment of ovarian cancer
Authors
Issue Date1990
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07357907.asp
Citation
Cancer Investigation, 1990, v. 8 n. 5, p. 467-470 How to Cite?
AbstractTwenty four patients with epithelial ovarian cancer, who were treated by chemotherapy after debulking surgery, were monitored by serial monthly CA125 estimation and half-yearly computerized axial tomogram (CAT) of abdomen and pelvis. The efficiency of these monitoring methods and that of clinical examination were compared. The use of CA125 alone was superior to the use of clinical assessment alone in the detection of tumor progression (p<0.01). The addition of the expensive routine half-yearly CAT examination did not improve the tumor detection rate (p>0.05). Hence, CAT examination should not be used routinely to detect recurrence of tumor in patients without a raised CA125 level. However, in patients with increased CA125 level, CAT examination had a place in locating and in determining the extent of the tumor which in selected patients may enable us to make changes in therapy without laparotomy and in other patients may help us to make a better assessment on whether further debulking is possible.
Persistent Identifierhttp://hdl.handle.net/10722/173171
ISSN
2015 Impact Factor: 2.231
2015 SCImago Journal Rankings: 0.991
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNgan, HYSen_US
dc.contributor.authorWong, LCen_US
dc.contributor.authorChan, SYWen_US
dc.contributor.authorMa, HKen_US
dc.date.accessioned2012-10-30T06:28:19Z-
dc.date.available2012-10-30T06:28:19Z-
dc.date.issued1990en_US
dc.identifier.citationCancer Investigation, 1990, v. 8 n. 5, p. 467-470en_US
dc.identifier.issn0735-7907en_US
dc.identifier.urihttp://hdl.handle.net/10722/173171-
dc.description.abstractTwenty four patients with epithelial ovarian cancer, who were treated by chemotherapy after debulking surgery, were monitored by serial monthly CA125 estimation and half-yearly computerized axial tomogram (CAT) of abdomen and pelvis. The efficiency of these monitoring methods and that of clinical examination were compared. The use of CA125 alone was superior to the use of clinical assessment alone in the detection of tumor progression (p<0.01). The addition of the expensive routine half-yearly CAT examination did not improve the tumor detection rate (p>0.05). Hence, CAT examination should not be used routinely to detect recurrence of tumor in patients without a raised CA125 level. However, in patients with increased CA125 level, CAT examination had a place in locating and in determining the extent of the tumor which in selected patients may enable us to make changes in therapy without laparotomy and in other patients may help us to make a better assessment on whether further debulking is possible.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/07357907.aspen_US
dc.relation.ispartofCancer Investigationen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntigens, Tumor-Associated, Carbohydrate - Blooden_US
dc.subject.meshAntineoplastic Agents - Therapeutic Useen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMonitoring, Physiologicen_US
dc.subject.meshOvarian Neoplasms - Blood - Drug Therapy - Surgeryen_US
dc.subject.meshPrognosisen_US
dc.subject.meshTomography, X-Ray Computeden_US
dc.titleRole of CA125 and abdominal pelvic computerized axial tomogram in the monitoring of chemotherapy treatment of ovarian canceren_US
dc.typeArticleen_US
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_US
dc.identifier.authorityNgan, HYS=rp00346en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3109/07357909009012069-
dc.identifier.pmid2265370-
dc.identifier.scopuseid_2-s2.0-0025615653en_US
dc.identifier.volume8en_US
dc.identifier.issue5en_US
dc.identifier.spage467en_US
dc.identifier.epage470en_US
dc.identifier.isiWOS:A1990ER28600003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridNgan, HYS=34571944100en_US
dc.identifier.scopusauthoridWong, LC=7402092003en_US
dc.identifier.scopusauthoridChan, SYW=7404255960en_US
dc.identifier.scopusauthoridMa, HK=7403095603en_US

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