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Article: Place of second-look laparotomy after 18 courses of chemotherapy in epithelial ovarian cancer

TitlePlace of second-look laparotomy after 18 courses of chemotherapy in epithelial ovarian cancer
Authors
Issue Date1989
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ANZJOG
Citation
Australian And New Zealand Journal Of Obstetrics And Gynaecology, 1989, v. 29 n. 1, p. 52-54 How to Cite?
AbstractThirty-two patients with epithelial carcinoma of the ovary underwent a second-look laparotomy after the completion of an average of 18 courses of adjuvant chemotherapy. Nine patients (28%) were found to have persistent disease. This low rate of positive second-look laparotomy is probably because these patients received chemotherapy for 18 months and in those patients whose tumour did not respond to the medication, the disease would progress and the patient died without becoming a candidate for laparotomy. There was no stage Ic patient whose second-look laparotomy was positive and the need for second-look laparotomy is questionable in such patients. Stage III/IV patients and patients with recurrence had a significantly higher positive second-look laparotomy rate than stage Ic/II patients, 44% and 7% respectively. In the present group of patients with positive tumour at second-look laparotomy, 33% responded to furtrher debulking operation and chemotherapy and remained disease free 15-33 months after completion of their second line chemotherapy treatment. For second-look laparotomy to be of maximum benefit to the patient, we recommend that it be performed after 12 courses of chemotherapy.
Persistent Identifierhttp://hdl.handle.net/10722/173155
ISSN
2015 Impact Factor: 1.738
2015 SCImago Journal Rankings: 0.814
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNgan, HYSen_US
dc.contributor.authorWong, LCen_US
dc.contributor.authorMa, HKen_US
dc.date.accessioned2012-10-30T06:28:13Z-
dc.date.available2012-10-30T06:28:13Z-
dc.date.issued1989en_US
dc.identifier.citationAustralian And New Zealand Journal Of Obstetrics And Gynaecology, 1989, v. 29 n. 1, p. 52-54en_US
dc.identifier.issn0004-8666en_US
dc.identifier.urihttp://hdl.handle.net/10722/173155-
dc.description.abstractThirty-two patients with epithelial carcinoma of the ovary underwent a second-look laparotomy after the completion of an average of 18 courses of adjuvant chemotherapy. Nine patients (28%) were found to have persistent disease. This low rate of positive second-look laparotomy is probably because these patients received chemotherapy for 18 months and in those patients whose tumour did not respond to the medication, the disease would progress and the patient died without becoming a candidate for laparotomy. There was no stage Ic patient whose second-look laparotomy was positive and the need for second-look laparotomy is questionable in such patients. Stage III/IV patients and patients with recurrence had a significantly higher positive second-look laparotomy rate than stage Ic/II patients, 44% and 7% respectively. In the present group of patients with positive tumour at second-look laparotomy, 33% responded to furtrher debulking operation and chemotherapy and remained disease free 15-33 months after completion of their second line chemotherapy treatment. For second-look laparotomy to be of maximum benefit to the patient, we recommend that it be performed after 12 courses of chemotherapy.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ANZJOGen_US
dc.relation.ispartofAustralian and New Zealand Journal of Obstetrics and Gynaecologyen_US
dc.subject.meshAdenocarcinoma - Drug Therapy - Pathology - Surgeryen_US
dc.subject.meshAdulten_US
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - Therapeutic Useen_US
dc.subject.meshCarcinoma - Drug Therapy - Pathology - Surgeryen_US
dc.subject.meshChemotherapy, Adjuvanten_US
dc.subject.meshCystadenocarcinoma - Drug Therapy - Pathology - Surgeryen_US
dc.subject.meshEndometriosis - Drug Therapy - Pathology - Surgeryen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLaparotomyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshOvarian Neoplasms - Drug Therapy - Pathology - Surgeryen_US
dc.subject.meshPrognosisen_US
dc.subject.meshReoperationen_US
dc.titlePlace of second-look laparotomy after 18 courses of chemotherapy in epithelial ovarian canceren_US
dc.typeArticleen_US
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_US
dc.identifier.authorityNgan, HYS=rp00346en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1479-828X.1989.tb02877.x-
dc.identifier.pmid2562603-
dc.identifier.scopuseid_2-s2.0-0024584203en_US
dc.identifier.volume29en_US
dc.identifier.issue1en_US
dc.identifier.spage52en_US
dc.identifier.epage54en_US
dc.identifier.isiWOS:A1989U868800013-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridNgan, HYS=34571944100en_US
dc.identifier.scopusauthoridWong, LC=7402092003en_US
dc.identifier.scopusauthoridMa, HK=7403095603en_US

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