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Article: Immunologic studies in patients with premature ovarian failure

TitleImmunologic studies in patients with premature ovarian failure
Authors
Issue Date1988
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.greenjournal.org
Citation
Obstetrics And Gynecology, 1988, v. 71 n. 4, p. 622-626 How to Cite?
AbstractTests for a range of autoantibodies, and counts of lymphocytes, B cells, T cells, and T cell subsets were performed in 45 Chinese patients with premature ovarian failure and 45 age-matched normal control subjects. Eight patients (18%) were positive for at least one autoantibody. Only one patient was positive for antiovarian antibody. Patients with autoantibodies had a significantly higher percentage of circulating B cells. The lymphocyte, T cell, CD4 +, and CD8 + counts in patients with premature ovarian failure were significantly higher than those in the control group, but the CD4:CD8 ratio was significantly lower in women with premature ovarian failure. There was a significant correlation between plasma estradiol levels and CD8 + counts, and a significant positive correlation between plasma estradiol levels and CD4:CD8 ratios. The changes in lymphocytes and lymphocyte subpopulations in premature ovarian failure may be due to estrogen deficiency.
Persistent Identifierhttp://hdl.handle.net/10722/173131
ISSN
2015 Impact Factor: 5.656
2015 SCImago Journal Rankings: 2.899
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, PCen_US
dc.contributor.authorTang, GWKen_US
dc.contributor.authorFu, KHen_US
dc.contributor.authorFan, MCen_US
dc.contributor.authorLawton, JWMen_US
dc.date.accessioned2012-10-30T06:28:06Z-
dc.date.available2012-10-30T06:28:06Z-
dc.date.issued1988en_US
dc.identifier.citationObstetrics And Gynecology, 1988, v. 71 n. 4, p. 622-626en_US
dc.identifier.issn0029-7844en_US
dc.identifier.urihttp://hdl.handle.net/10722/173131-
dc.description.abstractTests for a range of autoantibodies, and counts of lymphocytes, B cells, T cells, and T cell subsets were performed in 45 Chinese patients with premature ovarian failure and 45 age-matched normal control subjects. Eight patients (18%) were positive for at least one autoantibody. Only one patient was positive for antiovarian antibody. Patients with autoantibodies had a significantly higher percentage of circulating B cells. The lymphocyte, T cell, CD4 +, and CD8 + counts in patients with premature ovarian failure were significantly higher than those in the control group, but the CD4:CD8 ratio was significantly lower in women with premature ovarian failure. There was a significant correlation between plasma estradiol levels and CD8 + counts, and a significant positive correlation between plasma estradiol levels and CD4:CD8 ratios. The changes in lymphocytes and lymphocyte subpopulations in premature ovarian failure may be due to estrogen deficiency.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.greenjournal.orgen_US
dc.relation.ispartofObstetrics and Gynecologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAutoantibodies - Analysisen_US
dc.subject.meshB-Lymphocytes - Pathologyen_US
dc.subject.meshEstradiol - Blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphocytes - Classificationen_US
dc.subject.meshMenopause - Immunologyen_US
dc.subject.meshMenopause, Premature - Blood - Immunologyen_US
dc.subject.meshOvarian Diseases - Immunologyen_US
dc.titleImmunologic studies in patients with premature ovarian failureen_US
dc.typeArticleen_US
dc.identifier.emailHo, PC:pcho@hku.hken_US
dc.identifier.emailTang, GWK:gwktang@hkucc.hku.hken_US
dc.identifier.authorityHo, PC=rp00325en_US
dc.identifier.authorityTang, GWK=rp00328en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3258418-
dc.identifier.scopuseid_2-s2.0-0023895909en_US
dc.identifier.volume71en_US
dc.identifier.issue4en_US
dc.identifier.spage622en_US
dc.identifier.epage626en_US
dc.identifier.isiWOS:A1988M774700022-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHo, PC=7402211440en_US
dc.identifier.scopusauthoridTang, GWK=7401633864en_US
dc.identifier.scopusauthoridFu, KH=7202283800en_US
dc.identifier.scopusauthoridFan, MC=7201970839en_US
dc.identifier.scopusauthoridLawton, JWM=7102180792en_US

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