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Article: Multivariate discriminant analysis of the relationship between the hypo-osmotic swelling test and the in-vitro fertilizing capacity of human sperm

TitleMultivariate discriminant analysis of the relationship between the hypo-osmotic swelling test and the in-vitro fertilizing capacity of human sperm
Authors
Issue Date1988
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJA
Citation
International Journal Of Andrology, 1988, v. 11 n. 5, p. 369-378 How to Cite?
AbstractMultivariate discriminant analysis was used to evaluate the usefulness of routine semen parameters and the hypo-osmotic swelling test (HOST) as predictors of the in-vitro fertilizing capacity of human sperm as assessed by the zona-free hamster egg penetration assay (HEPA). Eighty-eight semen samples from untreated patients attending an infertility clinic were analysed. Semen samples were classified into the following three groups before statistical analysis: group 1 - positive sperm penetration (≥ 10%, n = 39); group 2 - borderline penetration rates for HEPA (> 0% but < 10%, n = 39) and group 3 - negative sperm penetration (0%, n = 10). The percentage of sperm with normal morphology and sperm count were found to be significant in discriminating between semen samples exhibiting different in-vitro fertilizing capacity. These two discriminating variables in combination gave an overall correct classification rate of 45.5%. The multivariate discriminant analysis was also performed after excluding the data of group 2 semen samples (n = 39), which exhibited borderline sperm penetration rates. As a result, three discriminating variables including semen volume, sperm cound and the percentage of sperm with normal morphology were selected. These three variables in combination could accurately predict whether a semen sample would exhibit positive sperm penetration (group 1) or negative sperm penetration (group 3) with an overall accuracy of 75.5%. The percentage of swollen sperm after hypo-osmotic treatment was not related to the HEPA result, as determined by linear correlation and multiple regression analyses, and did not give additional information about the in-vitro fertilizing capacity of sperm as evaluated by multivariate discriminant analysis.
Persistent Identifierhttp://hdl.handle.net/10722/173127
ISSN
2014 Impact Factor: 3.695
2015 SCImago Journal Rankings: 1.161
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, SYWen_US
dc.contributor.authorWang, Cen_US
dc.contributor.authorNg, Men_US
dc.contributor.authorSo, WWKen_US
dc.contributor.authorHo, PCen_US
dc.date.accessioned2012-10-30T06:28:05Z-
dc.date.available2012-10-30T06:28:05Z-
dc.date.issued1988en_US
dc.identifier.citationInternational Journal Of Andrology, 1988, v. 11 n. 5, p. 369-378en_US
dc.identifier.issn0105-6263en_US
dc.identifier.urihttp://hdl.handle.net/10722/173127-
dc.description.abstractMultivariate discriminant analysis was used to evaluate the usefulness of routine semen parameters and the hypo-osmotic swelling test (HOST) as predictors of the in-vitro fertilizing capacity of human sperm as assessed by the zona-free hamster egg penetration assay (HEPA). Eighty-eight semen samples from untreated patients attending an infertility clinic were analysed. Semen samples were classified into the following three groups before statistical analysis: group 1 - positive sperm penetration (≥ 10%, n = 39); group 2 - borderline penetration rates for HEPA (> 0% but < 10%, n = 39) and group 3 - negative sperm penetration (0%, n = 10). The percentage of sperm with normal morphology and sperm count were found to be significant in discriminating between semen samples exhibiting different in-vitro fertilizing capacity. These two discriminating variables in combination gave an overall correct classification rate of 45.5%. The multivariate discriminant analysis was also performed after excluding the data of group 2 semen samples (n = 39), which exhibited borderline sperm penetration rates. As a result, three discriminating variables including semen volume, sperm cound and the percentage of sperm with normal morphology were selected. These three variables in combination could accurately predict whether a semen sample would exhibit positive sperm penetration (group 1) or negative sperm penetration (group 3) with an overall accuracy of 75.5%. The percentage of swollen sperm after hypo-osmotic treatment was not related to the HEPA result, as determined by linear correlation and multiple regression analyses, and did not give additional information about the in-vitro fertilizing capacity of sperm as evaluated by multivariate discriminant analysis.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJAen_US
dc.relation.ispartofInternational Journal of Andrologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFertilityen_US
dc.subject.meshHumansen_US
dc.subject.meshInfertility, Male - Diagnosisen_US
dc.subject.meshMaleen_US
dc.subject.meshRegression Analysisen_US
dc.subject.meshSperm Counten_US
dc.subject.meshSperm-Ovum Interactionsen_US
dc.subject.meshSpermatozoa - Abnormalities - Physiologyen_US
dc.titleMultivariate discriminant analysis of the relationship between the hypo-osmotic swelling test and the in-vitro fertilizing capacity of human spermen_US
dc.typeArticleen_US
dc.identifier.emailHo, PC:pcho@hku.hken_US
dc.identifier.authorityHo, PC=rp00325en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2605.1988.tb01010.x-
dc.identifier.pmid3235206-
dc.identifier.scopuseid_2-s2.0-0023766087en_US
dc.identifier.volume11en_US
dc.identifier.issue5en_US
dc.identifier.spage369en_US
dc.identifier.epage378en_US
dc.identifier.isiWOS:A1988Q443000002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChan, SYW=7404255960en_US
dc.identifier.scopusauthoridWang, C=7501631357en_US
dc.identifier.scopusauthoridNg, M=7202076310en_US
dc.identifier.scopusauthoridSo, WWK=7004974015en_US
dc.identifier.scopusauthoridHo, PC=7402211440en_US

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