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Article: The in vitro metabolism of radioactive progesterone and testosterone by the gonads of the protandrous Rhabdosargus sarba at various sexual phases

TitleThe in vitro metabolism of radioactive progesterone and testosterone by the gonads of the protandrous Rhabdosargus sarba at various sexual phases
Authors
Issue Date1985
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygcen
Citation
General And Comparative Endocrinology, 1985, v. 59 n. 2, p. 171-183 How to Cite?
AbstractThe in vitro steroidogenic capacity of the gonadal tissue in the protandrous Rhabdosargus sarba was studied. Testicular and ovarian tissues from various sexual phases were used either separately or combined. With progesterone as precursor, high yield of 5β-reduced metabolites, and no 11-ketotestosterone or 11β-hydroxytestosterone were found. The production of 5β-pregnan-3α-ol-20-one and 5β-pregnane-3,20-dione was very high in incubations with testicular tissue from intersexes or males and was low in those with ovarian tissue only. The production of 17α-hydroxyprogesterone was high in the female but was low in other sexual phases. With testosterone as precursor, 11-ketotestosterone and 11β-hydroxytestosterone were identified. The latter was the most abundant and prominent polar steroid in all incubations. 5β-Reductase activity was high in the male and relatively low in the female. 5α-Reduced products, however, were absent. There was an increase in the production of androstenedione as the animal underwent sex reversal. The significance of this change in steroidogenesis in this protandrous fish is at present under investigation. Experimental results also indicated that in the intersexual gonad there may be interaction between the testicular component and the ovarian component in steroidgenesis.
Persistent Identifierhttp://hdl.handle.net/10722/173087
ISSN
2015 Impact Factor: 2.667
2015 SCImago Journal Rankings: 1.245
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYeung, WSBen_US
dc.contributor.authorChan, STHen_US
dc.date.accessioned2012-10-30T06:27:53Z-
dc.date.available2012-10-30T06:27:53Z-
dc.date.issued1985en_US
dc.identifier.citationGeneral And Comparative Endocrinology, 1985, v. 59 n. 2, p. 171-183en_US
dc.identifier.issn0016-6480en_US
dc.identifier.urihttp://hdl.handle.net/10722/173087-
dc.description.abstractThe in vitro steroidogenic capacity of the gonadal tissue in the protandrous Rhabdosargus sarba was studied. Testicular and ovarian tissues from various sexual phases were used either separately or combined. With progesterone as precursor, high yield of 5β-reduced metabolites, and no 11-ketotestosterone or 11β-hydroxytestosterone were found. The production of 5β-pregnan-3α-ol-20-one and 5β-pregnane-3,20-dione was very high in incubations with testicular tissue from intersexes or males and was low in those with ovarian tissue only. The production of 17α-hydroxyprogesterone was high in the female but was low in other sexual phases. With testosterone as precursor, 11-ketotestosterone and 11β-hydroxytestosterone were identified. The latter was the most abundant and prominent polar steroid in all incubations. 5β-Reductase activity was high in the male and relatively low in the female. 5α-Reduced products, however, were absent. There was an increase in the production of androstenedione as the animal underwent sex reversal. The significance of this change in steroidogenesis in this protandrous fish is at present under investigation. Experimental results also indicated that in the intersexual gonad there may be interaction between the testicular component and the ovarian component in steroidgenesis.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygcenen_US
dc.relation.ispartofGeneral and Comparative Endocrinologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCarbon Radioisotopesen_US
dc.subject.meshFemaleen_US
dc.subject.meshFishes - Growth & Developmenten_US
dc.subject.meshMaleen_US
dc.subject.meshOocytes - Metabolismen_US
dc.subject.meshOvary - Growth & Development - Metabolismen_US
dc.subject.meshProgesterone - Metabolismen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshSexual Maturationen_US
dc.subject.meshSteroids - Biosynthesisen_US
dc.subject.meshTestis - Growth & Development - Metabolismen_US
dc.subject.meshTestosterone - Metabolismen_US
dc.titleThe in vitro metabolism of radioactive progesterone and testosterone by the gonads of the protandrous Rhabdosargus sarba at various sexual phasesen_US
dc.typeArticleen_US
dc.identifier.emailYeung, WSB:wsbyeung@hkucc.hku.hken_US
dc.identifier.authorityYeung, WSB=rp00331en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0016-6480(85)90367-3-
dc.identifier.pmid4018557-
dc.identifier.scopuseid_2-s2.0-0021839861en_US
dc.identifier.volume59en_US
dc.identifier.issue2en_US
dc.identifier.spage171en_US
dc.identifier.epage183en_US
dc.identifier.isiWOS:A1985AMH7100001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYeung, WSB=7102370745en_US
dc.identifier.scopusauthoridChan, STH=24368283200en_US

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