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Article: Further studies on immunological parameters in gestational trophoblastic neoplasia

TitleFurther studies on immunological parameters in gestational trophoblastic neoplasia
Authors
Issue Date1984
Citation
Archives Of Gynecology, 1984, v. 234 n. 4, p. 255-261 How to Cite?
AbstractThe total blood lymphocyte counts, T-cell counts, B-cell counts, percentage of T cells bearing F(c) receptors for IgG (TG), lymphocyte responses to phytohaemagglutinin and concanavalin A and serum IgA levels were measured in 15 patients with hydatidiform mole, 32 patients with malignant trophoblastic disease, 30 pregnant controls, and 34 normal non-pregnant controls. The mean percentage of TG was similar in all four groups but the mean absolute number of TG in patients with malignant trophoblastic disease was significantly lower than that in normal non-pregnant controls, due to the lower mean lymphocyte count and T-cell count in the former group. An immune profile score based on the T-cell count, B-cell count, lymphocyte response to mitogens, and serum IgA level was useful in predicting the subsequent development of malignant trophoblastic disease in patients with hydatidiform mole but was not helpful in predicting resistance to chemotherapy in malignant trophoblastic disease.
Persistent Identifierhttp://hdl.handle.net/10722/173075
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, PCen_US
dc.contributor.authorWong, LCen_US
dc.contributor.authorLawton, JWMen_US
dc.contributor.authorMa, HKen_US
dc.date.accessioned2012-10-30T06:27:50Z-
dc.date.available2012-10-30T06:27:50Z-
dc.date.issued1984en_US
dc.identifier.citationArchives Of Gynecology, 1984, v. 234 n. 4, p. 255-261en_US
dc.identifier.issn0170-9925en_US
dc.identifier.urihttp://hdl.handle.net/10722/173075-
dc.description.abstractThe total blood lymphocyte counts, T-cell counts, B-cell counts, percentage of T cells bearing F(c) receptors for IgG (TG), lymphocyte responses to phytohaemagglutinin and concanavalin A and serum IgA levels were measured in 15 patients with hydatidiform mole, 32 patients with malignant trophoblastic disease, 30 pregnant controls, and 34 normal non-pregnant controls. The mean percentage of TG was similar in all four groups but the mean absolute number of TG in patients with malignant trophoblastic disease was significantly lower than that in normal non-pregnant controls, due to the lower mean lymphocyte count and T-cell count in the former group. An immune profile score based on the T-cell count, B-cell count, lymphocyte response to mitogens, and serum IgA level was useful in predicting the subsequent development of malignant trophoblastic disease in patients with hydatidiform mole but was not helpful in predicting resistance to chemotherapy in malignant trophoblastic disease.en_US
dc.languageengen_US
dc.relation.ispartofArchives of Gynecologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - Therapeutic Useen_US
dc.subject.meshB-Lymphocytes - Immunologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHydatidiform Mole - Drug Therapy - Immunologyen_US
dc.subject.meshImmunoglobulin A - Metabolismen_US
dc.subject.meshLeukocyte Counten_US
dc.subject.meshLymphocyte Activationen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPregnancyen_US
dc.subject.meshPrognosisen_US
dc.subject.meshReceptors, Fc - Immunologyen_US
dc.subject.meshT-Lymphocytes - Immunologyen_US
dc.subject.meshTrophoblastic Neoplasms - Drug Therapy - Immunologyen_US
dc.subject.meshUterine Neoplasms - Drug Therapy - Immunologyen_US
dc.titleFurther studies on immunological parameters in gestational trophoblastic neoplasiaen_US
dc.typeArticleen_US
dc.identifier.emailHo, PC:pcho@hku.hken_US
dc.identifier.authorityHo, PC=rp00325en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF02113810-
dc.identifier.pmid6089673-
dc.identifier.scopuseid_2-s2.0-0021272419en_US
dc.identifier.volume234en_US
dc.identifier.issue4en_US
dc.identifier.spage255en_US
dc.identifier.epage261en_US
dc.identifier.isiWOS:A1984TC91900003-
dc.identifier.scopusauthoridHo, PC=7402211440en_US
dc.identifier.scopusauthoridWong, LC=7402092003en_US
dc.identifier.scopusauthoridLawton, JWM=7102180792en_US
dc.identifier.scopusauthoridMa, HK=7403095603en_US

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