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Article: Schwangerschaftsprotein 1 (SP1) in serum and cerebrospinal fluid of patients with gestational trophoblastic disease

TitleSchwangerschaftsprotein 1 (SP1) in serum and cerebrospinal fluid of patients with gestational trophoblastic disease
Authors
Issue Date1983
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJOG
Citation
British Journal Of Obstetrics And Gynaecology, 1983, v. 90 n. 4, p. 317-322 How to Cite?
AbstractThe β subunit of human chorionic gonadotrophin (β-hCG) and Schwangerschaftsprotein 1 (SP1) were measured by radioimmunoassay in the serum and cerebrospinal fluid (CSF) of 46 postmolar and postpartum patients who developed gestational trophoblastic disease. There was a significant correlation between β-hCG and SP1 serum levels. The mean serum SP1 level in high-risk patients was significantly higher than that in low-risk patients. There was a significant correlation between serum and CSF β-hCG levels. The ratio of serum to CSF β-hCG levels was low in the 3 patients with clinical evidence of intracranial metastasis. SP1 was present in the CSF of only one of these 3 patients, but it could be detected in the CSF of another 4 patients without clinical evidence of metastases in the central nervous system. The 2 low-risk patients with SP1 present in the CSF showed poor response to intramuscular methotrexate.
Persistent Identifierhttp://hdl.handle.net/10722/173067
ISSN
2001 Impact Factor: 2.321
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, PCen_US
dc.contributor.authorMa, HKen_US
dc.date.accessioned2012-10-30T06:27:48Z-
dc.date.available2012-10-30T06:27:48Z-
dc.date.issued1983en_US
dc.identifier.citationBritish Journal Of Obstetrics And Gynaecology, 1983, v. 90 n. 4, p. 317-322en_US
dc.identifier.issn0306-5456en_US
dc.identifier.urihttp://hdl.handle.net/10722/173067-
dc.description.abstractThe β subunit of human chorionic gonadotrophin (β-hCG) and Schwangerschaftsprotein 1 (SP1) were measured by radioimmunoassay in the serum and cerebrospinal fluid (CSF) of 46 postmolar and postpartum patients who developed gestational trophoblastic disease. There was a significant correlation between β-hCG and SP1 serum levels. The mean serum SP1 level in high-risk patients was significantly higher than that in low-risk patients. There was a significant correlation between serum and CSF β-hCG levels. The ratio of serum to CSF β-hCG levels was low in the 3 patients with clinical evidence of intracranial metastasis. SP1 was present in the CSF of only one of these 3 patients, but it could be detected in the CSF of another 4 patients without clinical evidence of metastases in the central nervous system. The 2 low-risk patients with SP1 present in the CSF showed poor response to intramuscular methotrexate.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJOGen_US
dc.relation.ispartofBritish Journal of Obstetrics and Gynaecologyen_US
dc.subject.meshBrain Neoplasms - Secondaryen_US
dc.subject.meshChorionic Gonadotropin - Blood - Cerebrospinal Fluiden_US
dc.subject.meshChorionic Gonadotropin, Beta Subunit, Humanen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshPeptide Fragments - Blood - Cerebrospinal Fluiden_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Proteins - Analysisen_US
dc.subject.meshPregnancy-Specific Beta 1-Glycoproteins - Analysis - Cerebrospinal Fluiden_US
dc.subject.meshPrognosisen_US
dc.subject.meshTrophoblastic Neoplasms - Blood - Cerebrospinal Fluid - Drug Therapyen_US
dc.subject.meshUterine Neoplasms - Blood - Cerebrospinal Fluid - Drug Therapyen_US
dc.titleSchwangerschaftsprotein 1 (SP1) in serum and cerebrospinal fluid of patients with gestational trophoblastic diseaseen_US
dc.typeArticleen_US
dc.identifier.emailHo, PC:pcho@hku.hken_US
dc.identifier.authorityHo, PC=rp00325en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1471-0528.1983.tb08916.x-
dc.identifier.pmid6188478en_US
dc.identifier.scopuseid_2-s2.0-0020531885en_US
dc.identifier.volume90en_US
dc.identifier.issue4en_US
dc.identifier.spage317en_US
dc.identifier.epage322en_US
dc.identifier.isiWOS:A1983QM95500006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridHo, PC=7402211440en_US
dc.identifier.scopusauthoridMa, HK=7403095603en_US

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