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Article: Pathways of purine ribonucleotide biosynthesis in the adult worm Metastrongylus apri (nematoda: Metastronglyloidea) from pig lung

TitlePathways of purine ribonucleotide biosynthesis in the adult worm Metastrongylus apri (nematoda: Metastronglyloidea) from pig lung
Authors
Issue Date1981
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/molbiopara
Citation
Molecular And Biochemical Parasitology, 1981, v. 2 n. 5-6, p. 285-293 How to Cite?
AbstractThe pathways of purine ribonucleotide synthesis and interconversion that are operative in the intact adult pig lung worm Metastrongylus apri were identified by radioisotope tracing. The rate of [14C]- glycine incorporation into purines was low but sufficient to demonstrate synthesis de novo. Radioactively labelled adenine, hypoxanthine and guanine were readily taken up and converted to the corresponding mononucleotides. Most of the AMP and GMP formed were phosphorylated to the triphosphates. These two nucleotides were interconvertable by pathways in which IMP is an intermediate. Adenosine was converted to nucleotides by direct phosphorylation as well as via formation of hypoxanthine. The rate of synthesis of adenine nucleotides from hypoxanthine was 5-7 times that of guanine nucleotides; conversion of IMP to AMP and to xanthosine 5′-monophosphate were the rate-limiting steps. © 1981.
Persistent Identifierhttp://hdl.handle.net/10722/173061
ISSN
2015 Impact Factor: 2.068
2015 SCImago Journal Rankings: 1.273
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, PCLen_US
dc.contributor.authorYeung, SBen_US
dc.date.accessioned2012-10-30T06:27:46Z-
dc.date.available2012-10-30T06:27:46Z-
dc.date.issued1981en_US
dc.identifier.citationMolecular And Biochemical Parasitology, 1981, v. 2 n. 5-6, p. 285-293en_US
dc.identifier.issn0166-6851en_US
dc.identifier.urihttp://hdl.handle.net/10722/173061-
dc.description.abstractThe pathways of purine ribonucleotide synthesis and interconversion that are operative in the intact adult pig lung worm Metastrongylus apri were identified by radioisotope tracing. The rate of [14C]- glycine incorporation into purines was low but sufficient to demonstrate synthesis de novo. Radioactively labelled adenine, hypoxanthine and guanine were readily taken up and converted to the corresponding mononucleotides. Most of the AMP and GMP formed were phosphorylated to the triphosphates. These two nucleotides were interconvertable by pathways in which IMP is an intermediate. Adenosine was converted to nucleotides by direct phosphorylation as well as via formation of hypoxanthine. The rate of synthesis of adenine nucleotides from hypoxanthine was 5-7 times that of guanine nucleotides; conversion of IMP to AMP and to xanthosine 5′-monophosphate were the rate-limiting steps. © 1981.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/molbioparaen_US
dc.relation.ispartofMolecular and Biochemical Parasitologyen_US
dc.subject.meshAdenine Nucleotides - Biosynthesisen_US
dc.subject.meshAnimalsen_US
dc.subject.meshGlycine - Pharmacologyen_US
dc.subject.meshGuanine Nucleotides - Biosynthesisen_US
dc.subject.meshLung - Parasitologyen_US
dc.subject.meshMetastrongyloidea - Metabolismen_US
dc.subject.meshPurine Nucleotides - Biosynthesisen_US
dc.subject.meshRibonucleotides - Biosynthesisen_US
dc.subject.meshSwineen_US
dc.titlePathways of purine ribonucleotide biosynthesis in the adult worm Metastrongylus apri (nematoda: Metastronglyloidea) from pig lungen_US
dc.typeArticleen_US
dc.identifier.emailYeung, SB:wsbyeung@hkucc.hku.hken_US
dc.identifier.authorityYeung, SB=rp00331en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0166-6851(81)90081-5-
dc.identifier.pmid7242568-
dc.identifier.scopuseid_2-s2.0-0019555210en_US
dc.identifier.volume2en_US
dc.identifier.issue5-6en_US
dc.identifier.spage285en_US
dc.identifier.epage293en_US
dc.identifier.isiWOS:A1981LM64800003-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridWong, PCL=10239600000en_US
dc.identifier.scopusauthoridYeung, SB=7102370745en_US

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