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Article: Effects of donor steatosis on liver biochemistry and significance of body mass index in predicting steatosis

TitleEffects of donor steatosis on liver biochemistry and significance of body mass index in predicting steatosis
Authors
KeywordsBody Mass Index
Donor Hepatectomy
Fatty Change
Liver Transplantation
Living Donor
Steatotic Donor
Issue Date2012
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/1365182X.asp
Citation
Hpb, 2012, v. 14 n. 9, p. 619-624 How to Cite?
AbstractBackground: Hepatic steatosis is a major concern in living donor liver transplantation. Factors affecting hepatic functional status after a donor right hepatectomy (with the middle hepatic vein included in the graft) with a focus on changes owing to steatosis were retrospectively studied. Methods: Donors (n= 325) were categorized into three groups: G0 (no steatosis, n= 178), G1 (< = 10% steatosis, n= 128) and G2 (>10% steatosis, n= 19). Donors with >20% steatosis were excluded. Changes in aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin levels and prothrombin time (PT) were assessed. Factors predicting steatosis were also assessed. A liver biopsy was performed on selected donors. Results: The ALT level rose until day 3 in G1 and day 6 in G2 (P < 0.05). The AST level rose until day 7 in G2 (P < 0.05) but stayed unchanged in G1. The bilirubin level was higher only on day 1 in G2 (P < 0.05). By day 30, no significant difference between any groups was noted. Receiver-operating characteristic (ROC) area under the curve for body mass index (BMI) on predicting steatosis was 0.75 [confidence interval (CI) = 69-80]. Among donors with a BMI > 23.5 kg/m 2, 75% had steatosis. Five donors had >20% steatosis and were not assessed. Conclusion: Using a liver with up to 20% steatosis in right liver donation, even if the middle hepatic vein is included in the graft, is safe. For Asian donors, a BMI > 23.5 kg/m 2 is a guide in deciding whether to perform a liver biopsy for steatosis. © 2012 International Hepato-Pancreato-Biliary Association.
Persistent Identifierhttp://hdl.handle.net/10722/173042
ISSN
2015 Impact Factor: 2.918
2015 SCImago Journal Rankings: 1.586
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSiriwardana, RCen_US
dc.contributor.authorChan, SCen_US
dc.contributor.authorChok, KSHen_US
dc.contributor.authorLo, CMen_US
dc.contributor.authorFan, STen_US
dc.date.accessioned2012-10-30T06:26:56Z-
dc.date.available2012-10-30T06:26:56Z-
dc.date.issued2012en_US
dc.identifier.citationHpb, 2012, v. 14 n. 9, p. 619-624en_US
dc.identifier.issn1365-182Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/173042-
dc.description.abstractBackground: Hepatic steatosis is a major concern in living donor liver transplantation. Factors affecting hepatic functional status after a donor right hepatectomy (with the middle hepatic vein included in the graft) with a focus on changes owing to steatosis were retrospectively studied. Methods: Donors (n= 325) were categorized into three groups: G0 (no steatosis, n= 178), G1 (< = 10% steatosis, n= 128) and G2 (>10% steatosis, n= 19). Donors with >20% steatosis were excluded. Changes in aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin levels and prothrombin time (PT) were assessed. Factors predicting steatosis were also assessed. A liver biopsy was performed on selected donors. Results: The ALT level rose until day 3 in G1 and day 6 in G2 (P < 0.05). The AST level rose until day 7 in G2 (P < 0.05) but stayed unchanged in G1. The bilirubin level was higher only on day 1 in G2 (P < 0.05). By day 30, no significant difference between any groups was noted. Receiver-operating characteristic (ROC) area under the curve for body mass index (BMI) on predicting steatosis was 0.75 [confidence interval (CI) = 69-80]. Among donors with a BMI > 23.5 kg/m 2, 75% had steatosis. Five donors had >20% steatosis and were not assessed. Conclusion: Using a liver with up to 20% steatosis in right liver donation, even if the middle hepatic vein is included in the graft, is safe. For Asian donors, a BMI > 23.5 kg/m 2 is a guide in deciding whether to perform a liver biopsy for steatosis. © 2012 International Hepato-Pancreato-Biliary Association.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/1365182X.aspen_US
dc.relation.ispartofHPBen_US
dc.subjectBody Mass Indexen_US
dc.subjectDonor Hepatectomyen_US
dc.subjectFatty Changeen_US
dc.subjectLiver Transplantationen_US
dc.subjectLiving Donoren_US
dc.subjectSteatotic Donoren_US
dc.titleEffects of donor steatosis on liver biochemistry and significance of body mass index in predicting steatosisen_US
dc.typeArticleen_US
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_US
dc.identifier.emailFan, ST: stfan@hku.hken_US
dc.identifier.emailSiriwardana, RC: rohan@hku.hk-
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hk-
dc.identifier.authorityLo, CM=rp00412en_US
dc.identifier.authorityFan, ST=rp00355en_US
dc.identifier.authorityChan, SC=rp01568-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1477-2574.2012.00491.xen_US
dc.identifier.pmid22882199-
dc.identifier.scopuseid_2-s2.0-84865126884en_US
dc.identifier.hkuros211017-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84865126884&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue9en_US
dc.identifier.spage619en_US
dc.identifier.epage624en_US
dc.identifier.isiWOS:000307500300008-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSiriwardana, RC=35321203400en_US
dc.identifier.scopusauthoridChan, SC=36901164300en_US
dc.identifier.scopusauthoridChok, KSH=6508229426en_US
dc.identifier.scopusauthoridLo, CM=7401771672en_US
dc.identifier.scopusauthoridFan, ST=7402678224en_US

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