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Article: Efficacy of fine-needle aspiration in diagnosing cervical nodal metastasis from nasopharyngeal carcinoma after radiotherapy

TitleEfficacy of fine-needle aspiration in diagnosing cervical nodal metastasis from nasopharyngeal carcinoma after radiotherapy
Authors
KeywordsCervical Lymph Node Metastasis
Fine-Needle Aspiration
Level Of Evidence: 3
Magnetic Resonance Imaging
Nasopharyngeal Carcinoma
Plasma Epstein-Barr Virus
Issue Date2013
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.laryngoscope.com/
Citation
Laryngoscope, 2013, v. 123 n. 1, p. 134-139 How to Cite?
AbstractObjectives/Hypothesis:: Our purpose was to study the effect of previous radiotherapy (RT) on the efficacy of fine-needle aspiration (FNA) in diagnosing cervical nodal metastasis in nasopharyngeal carcinoma (NPC). Study Design:: Case-control study. Methods:: The diagnostic efficacy of FNA in a group of patients with residual or recurrent cervical lymphadenopathy after previous RT for NPC was compared with a cohort of patients with primary NPC before RT during the same period. Results:: Between 2008 and 2010, 50 patients were included for each group in the study. The specificity (100% vs. 88%, P = .12) and positive predictive value (100% vs. 89%, P = .12) was comparable in the two groups. However, the sensitivity (82% vs. 40%, P = .04), negative predictive value (NPV; 74% vs. 36%, P = .03), and accuracy (88% vs. 54%, P = .05) were significantly worse after previous RT. Previous RT was the only factor that was significantly associated with worse diagnostic efficacy (P = .001). When used together with plasma Epstein-Barr virus (pEBV)-DNA level and magnetic resonance imaging (MRI) findings (triple assessment), the diagnostic efficacy was significantly improved, especially regarding sensitivity (40% vs. 98%, P = .01), NPV (36% vs. 96%, P = .02), and accuracy (54% vs. 97%, P = .03). Conclusions:: Diagnostic efficacy of FNA for residual or recurrent cervical lymph node metastasis in NPC is significantly reduced after previous RT. To ensure that the proper diagnosis is made early, triple assessment using FNA, pEBV-DNA, and MRI should be adopted in this scenario. © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/173041
ISSN
2015 Impact Factor: 2.272
2015 SCImago Journal Rankings: 1.342
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, JYWen_US
dc.contributor.authorChan, RCLen_US
dc.contributor.authorChow, VLYen_US
dc.contributor.authorTo, VSHen_US
dc.contributor.authorWei, WIen_US
dc.date.accessioned2012-10-30T06:26:55Z-
dc.date.available2012-10-30T06:26:55Z-
dc.date.issued2013en_US
dc.identifier.citationLaryngoscope, 2013, v. 123 n. 1, p. 134-139en_US
dc.identifier.issn0023-852Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/173041-
dc.description.abstractObjectives/Hypothesis:: Our purpose was to study the effect of previous radiotherapy (RT) on the efficacy of fine-needle aspiration (FNA) in diagnosing cervical nodal metastasis in nasopharyngeal carcinoma (NPC). Study Design:: Case-control study. Methods:: The diagnostic efficacy of FNA in a group of patients with residual or recurrent cervical lymphadenopathy after previous RT for NPC was compared with a cohort of patients with primary NPC before RT during the same period. Results:: Between 2008 and 2010, 50 patients were included for each group in the study. The specificity (100% vs. 88%, P = .12) and positive predictive value (100% vs. 89%, P = .12) was comparable in the two groups. However, the sensitivity (82% vs. 40%, P = .04), negative predictive value (NPV; 74% vs. 36%, P = .03), and accuracy (88% vs. 54%, P = .05) were significantly worse after previous RT. Previous RT was the only factor that was significantly associated with worse diagnostic efficacy (P = .001). When used together with plasma Epstein-Barr virus (pEBV)-DNA level and magnetic resonance imaging (MRI) findings (triple assessment), the diagnostic efficacy was significantly improved, especially regarding sensitivity (40% vs. 98%, P = .01), NPV (36% vs. 96%, P = .02), and accuracy (54% vs. 97%, P = .03). Conclusions:: Diagnostic efficacy of FNA for residual or recurrent cervical lymph node metastasis in NPC is significantly reduced after previous RT. To ensure that the proper diagnosis is made early, triple assessment using FNA, pEBV-DNA, and MRI should be adopted in this scenario. © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.laryngoscope.com/en_US
dc.relation.ispartofLaryngoscopeen_US
dc.subjectCervical Lymph Node Metastasisen_US
dc.subjectFine-Needle Aspirationen_US
dc.subjectLevel Of Evidence: 3en_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectNasopharyngeal Carcinomaen_US
dc.subjectPlasma Epstein-Barr Virusen_US
dc.titleEfficacy of fine-needle aspiration in diagnosing cervical nodal metastasis from nasopharyngeal carcinoma after radiotherapyen_US
dc.typeArticleen_US
dc.identifier.emailChan, JYW: jywchan1@hku.hken_US
dc.identifier.emailTo, VSH: doctorto@hku.hken_US
dc.identifier.authorityChan, JYW=rp01314en_US
dc.identifier.authorityTo, VSH=rp01385en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/lary.23373en_US
dc.identifier.pmid22907783-
dc.identifier.scopuseid_2-s2.0-84871716413en_US
dc.identifier.hkuros215933-
dc.identifier.eissn1531-4995-
dc.identifier.isiWOS:000312946400026-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChan, JYW=27171772200en_US
dc.identifier.scopusauthoridChan, RCL=54399925900en_US
dc.identifier.scopusauthoridChow, VLY=36807611300en_US
dc.identifier.scopusauthoridTo, VSH=35957345400en_US
dc.identifier.scopusauthoridWei, WI=55251021200en_US

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