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Article: Ex-vivo haemodynamic models for the study of Stanford type B aortic dissection in isolated porcine aorta

TitleEx-vivo haemodynamic models for the study of Stanford type B aortic dissection in isolated porcine aorta
Authors
KeywordsSodium chloride
Animal experiment
Aorta balloon
Aorta dissection
Ex vivo study
Issue Date2012
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejvs
Citation
European Journal of Vascular and Endovascular Surgery, 2012, v. 44 n. 4, p. 399-405 How to Cite?
AbstractOBJECTIVES: The aim of this study is to present novel ex-vivo models in the study of complex haemodynamical changes in Stanford type B aortic dissection (TBAD). MATERIALS AND METHODS: Fifteen fresh porcine aortas were harvested and preserved with 4 degrees C saline. Ex-vivo models were developed to simulate TBAD in three different situations: model A with patent false lumen, model B with distal re-entry only and model C with proximal primary entry only. These models were connected to standardised pulsatile pumps and the pressure waveforms were monitored and compared. The aortas were scanned with ultrasonography and subjected to post-experiment autopsy. RESULTS: The three different models were successfully created (n = 13). Pulsatile flow testing was successful and the shapes of the pressure waveforms were similar to those taken from human aorta. Post-testing gross examination confirmed the success of modelling. CONCLUSION: Porcine aortas may prove to be useful ex-vivo models in the study of aortic dissection haemodynamics. These models are reproducible and may be used in the study of complex haemodynamic forces during the development and propagation of TBAD. Our three porcine models give a potential possibility in helping clinicians isolate and analyse complex haemodynamical factors in the development, propagation and prognosis of TBAD.
Persistent Identifierhttp://hdl.handle.net/10722/173037
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.723
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorQing, KXen_US
dc.contributor.authorChan, YCen_US
dc.contributor.authorLau, SFen_US
dc.contributor.authorYiu, WKen_US
dc.contributor.authorTing, ACWen_US
dc.contributor.authorCheng, SWKen_US
dc.date.accessioned2012-10-30T06:26:50Z-
dc.date.available2012-10-30T06:26:50Z-
dc.date.issued2012en_US
dc.identifier.citationEuropean Journal of Vascular and Endovascular Surgery, 2012, v. 44 n. 4, p. 399-405en_US
dc.identifier.issn1078-5884en_US
dc.identifier.urihttp://hdl.handle.net/10722/173037-
dc.description.abstractOBJECTIVES: The aim of this study is to present novel ex-vivo models in the study of complex haemodynamical changes in Stanford type B aortic dissection (TBAD). MATERIALS AND METHODS: Fifteen fresh porcine aortas were harvested and preserved with 4 degrees C saline. Ex-vivo models were developed to simulate TBAD in three different situations: model A with patent false lumen, model B with distal re-entry only and model C with proximal primary entry only. These models were connected to standardised pulsatile pumps and the pressure waveforms were monitored and compared. The aortas were scanned with ultrasonography and subjected to post-experiment autopsy. RESULTS: The three different models were successfully created (n = 13). Pulsatile flow testing was successful and the shapes of the pressure waveforms were similar to those taken from human aorta. Post-testing gross examination confirmed the success of modelling. CONCLUSION: Porcine aortas may prove to be useful ex-vivo models in the study of aortic dissection haemodynamics. These models are reproducible and may be used in the study of complex haemodynamic forces during the development and propagation of TBAD. Our three porcine models give a potential possibility in helping clinicians isolate and analyse complex haemodynamical factors in the development, propagation and prognosis of TBAD.en_US
dc.languageengen_US
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejvsen_US
dc.relation.ispartofEuropean Journal of Vascular and Endovascular Surgeryen_US
dc.subjectSodium chlorideen_US
dc.subjectAnimal experimenten_US
dc.subjectAorta balloonen_US
dc.subjectAorta dissectionen_US
dc.subjectEx vivo studyen_US
dc.titleEx-vivo haemodynamic models for the study of Stanford type B aortic dissection in isolated porcine aortaen_US
dc.typeArticleen_US
dc.identifier.emailChan, YC: ycchan88@hkucc.hku.hken_US
dc.identifier.emailLau, SF: lausf@hku.hken_US
dc.identifier.emailYiu, WK: waikiyiu@hku.hk-
dc.identifier.emailTing, ACW: tingacw@hku.hk-
dc.identifier.emailCheng, SWK: wkcheng@hkucc.hku.hk-
dc.identifier.authorityYiu, WK=rp00311en_US
dc.identifier.authorityCheng, SWK=rp00374en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ejvs.2012.06.004en_US
dc.identifier.pmid22835767-
dc.identifier.scopuseid_2-s2.0-84866941890en_US
dc.identifier.hkuros212347-
dc.identifier.volume44-
dc.identifier.issue4-
dc.identifier.spage399-
dc.identifier.epage405-
dc.identifier.eissn1532-2165-
dc.identifier.isiWOS:000310412300009-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridCheng, SWK=7404684779en_US
dc.identifier.scopusauthoridTing, ACW=7102858552en_US
dc.identifier.scopusauthoridYiu, WK=12763171700en_US
dc.identifier.scopusauthoridLau, SF=55318361100en_US
dc.identifier.scopusauthoridChan, YC=55226588600en_US
dc.identifier.scopusauthoridQing, KX=36004840500en_US

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