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Article: Recurrent nasopharyngeal carcinoma after salvage nasopharyngectomy

TitleRecurrent nasopharyngeal carcinoma after salvage nasopharyngectomy
Authors
KeywordsAntineoplastic agent
Cancer chemotherapy
Cancer radiotherapy
Cancer recurrence
Cancer risk
Issue Date2012
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archoto.com
Citation
Archives of Otolaryngology - Head & Neck Surgery, 2012, v. 138 n. 6, p. 572-576 How to Cite?
AbstractObjective: To study the safety and oncological outcome of salvage surgery for local tumor recurrence after previous maxillary swing nasopharyngectomy. Setting: University hospital. Patients: Between 1998 and 2011, a total of 252 patients who had local tumor recurrence after previous nasopharyngectomy were recruited for the study.Main Outcome Measures: The locations of the recurrent tumor, operability, and surgical details of resection and reconstruction, as well as the complications and oncological results, were studied. Results: The local recurrence rate after nasopharyngectomy was 13.1%, the risk of which was significantly higher in patients with positive resection margins (39.6% vs 6.9%; P=.006). The chance of the development of local recurrence was significantly lower in patients who had received postoperative chemoradiation therapy than in patients who did not (29.4% vs 64.3%; P=.04). Overall, 63.6% of the patients with local recurrence were amenable to further surgery. Depending on the location of the tumor, remaxillary swing (n=10), contralateral maxillary swing (n=8), or central palatal resection (n=3)was performed. Free-flap coverage of the exposed skull base and the petrosal internal carotid artery was required in 12 patients. There was no evidence of hospital mortality or major complications associated with the surgery. The mean duration of follow-up was 22.4 months, and the overall disease-specific survival in the group of patients who underwent surgery was 80.9%. Conclusions: Surgical salvage for local tumor recurrence after previous nasopharyngectomy is safe, with a good oncological outcome. In the presence of previous maxillary swing surgery, reswing or contralateral swing operation is feasible, without major complications.
Persistent Identifierhttp://hdl.handle.net/10722/173031
ISSN
2014 Impact Factor: 2.327
References

 

DC FieldValueLanguage
dc.contributor.authorChan, JYWen_US
dc.contributor.authorWei, WIen_US
dc.date.accessioned2012-10-30T06:26:42Z-
dc.date.available2012-10-30T06:26:42Z-
dc.date.issued2012en_US
dc.identifier.citationArchives of Otolaryngology - Head & Neck Surgery, 2012, v. 138 n. 6, p. 572-576en_US
dc.identifier.issn0886-4470en_US
dc.identifier.urihttp://hdl.handle.net/10722/173031-
dc.description.abstractObjective: To study the safety and oncological outcome of salvage surgery for local tumor recurrence after previous maxillary swing nasopharyngectomy. Setting: University hospital. Patients: Between 1998 and 2011, a total of 252 patients who had local tumor recurrence after previous nasopharyngectomy were recruited for the study.Main Outcome Measures: The locations of the recurrent tumor, operability, and surgical details of resection and reconstruction, as well as the complications and oncological results, were studied. Results: The local recurrence rate after nasopharyngectomy was 13.1%, the risk of which was significantly higher in patients with positive resection margins (39.6% vs 6.9%; P=.006). The chance of the development of local recurrence was significantly lower in patients who had received postoperative chemoradiation therapy than in patients who did not (29.4% vs 64.3%; P=.04). Overall, 63.6% of the patients with local recurrence were amenable to further surgery. Depending on the location of the tumor, remaxillary swing (n=10), contralateral maxillary swing (n=8), or central palatal resection (n=3)was performed. Free-flap coverage of the exposed skull base and the petrosal internal carotid artery was required in 12 patients. There was no evidence of hospital mortality or major complications associated with the surgery. The mean duration of follow-up was 22.4 months, and the overall disease-specific survival in the group of patients who underwent surgery was 80.9%. Conclusions: Surgical salvage for local tumor recurrence after previous nasopharyngectomy is safe, with a good oncological outcome. In the presence of previous maxillary swing surgery, reswing or contralateral swing operation is feasible, without major complications.en_US
dc.languageengen_US
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archoto.comen_US
dc.relation.ispartofArchives of Otolaryngology - Head & Neck Surgeryen_US
dc.subjectAntineoplastic agent-
dc.subjectCancer chemotherapy-
dc.subjectCancer radiotherapy-
dc.subjectCancer recurrence-
dc.subjectCancer risk-
dc.subject.meshYoung adulten_US
dc.subject.meshSalvage therapy - Adverse effects - Methodsen_US
dc.subject.meshPharyngectomy - Adverse effects - Methodsen_US
dc.subject.meshNeoplasm, Residualen_US
dc.subject.meshNeoplasm recurrence, Local - Pathology - Surgeryen_US
dc.subject.meshNasopharyngeal neoplasms - Pathology - Surgeryen_US
dc.subject.meshNasal surgical procedures - Adverse effects - Methodsen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMedical illustrationen_US
dc.subject.meshMaleen_US
dc.subject.meshMagnetic resonance imagingen_US
dc.subject.meshHumansen_US
dc.subject.meshHong Kongen_US
dc.subject.meshFemaleen_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshAgeden_US
dc.subject.meshAdulten_US
dc.titleRecurrent nasopharyngeal carcinoma after salvage nasopharyngectomyen_US
dc.typeArticleen_US
dc.identifier.emailChan, JYW: jywchan1@hku.hken_US
dc.identifier.emailWei, WI: hrmswwi@hku.hk-
dc.identifier.authorityChan, JYW=rp01314en_US
dc.identifier.authorityWei, WI=rp00323-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1001/archoto.2012.832en_US
dc.identifier.pmid22710509-
dc.identifier.scopuseid_2-s2.0-84863455546en_US
dc.identifier.hkuros200746-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863455546&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume138en_US
dc.identifier.issue6en_US
dc.identifier.spage572en_US
dc.identifier.epage576en_US
dc.identifier.eissn2168-619X-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWei, WI=55251021200en_US
dc.identifier.scopusauthoridChan, JYW=27171772200en_US

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