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Article: An update on targeting Hippo-YAP signaling in liver cancer

TitleAn update on targeting Hippo-YAP signaling in liver cancer
Authors
Issue Date2012
PublisherInforma Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/ett
Citation
Expert Opinion On Therapeutic Targets, 2012, v. 16 n. 3, p. 243-247 How to Cite?
Abstract
Hepatocellular carcinoma (HCC) is an aggressive malignancy with approximately half a million cases diagnosed each year. Although strategies in surgical interventions have been investigated and applied, the prognosis is still poor. Novel chemotherapy for advanced stage HCC patients is still greatly in need. HippoYes-associated protein (YAP) signaling pathway controls organ size by regulating both cell proliferation and apoptosis during normal development. The pathway also has a prominent role in suppressing tumor growth, with the most evident contribution in HCC. In recent years, regulators of this pathway have gradually been revealed, providing new information for understanding this complex yet important growth-control signaling. This knowledge provides a basis for rational design of therapeutics against cancer that depends upon HippoYAP signaling for growth. © 2012 Informa UK, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/173030
ISSN
2013 Impact Factor: 4.901
2013 SCImago Journal Rankings: 2.101
ISI Accession Number ID
References

 

Author Affiliations
  1. Yong Loo Lin School of Medicine
  2. Nanjing Medical University
  3. Roche RandD Center (China) Ltd
DC FieldValueLanguage
dc.contributor.authorLiu, AMen_US
dc.contributor.authorXu, Zen_US
dc.contributor.authorLuk, JMen_US
dc.date.accessioned2012-10-30T06:26:40Z-
dc.date.available2012-10-30T06:26:40Z-
dc.date.issued2012en_US
dc.identifier.citationExpert Opinion On Therapeutic Targets, 2012, v. 16 n. 3, p. 243-247en_US
dc.identifier.issn1472-8222en_US
dc.identifier.urihttp://hdl.handle.net/10722/173030-
dc.description.abstractHepatocellular carcinoma (HCC) is an aggressive malignancy with approximately half a million cases diagnosed each year. Although strategies in surgical interventions have been investigated and applied, the prognosis is still poor. Novel chemotherapy for advanced stage HCC patients is still greatly in need. HippoYes-associated protein (YAP) signaling pathway controls organ size by regulating both cell proliferation and apoptosis during normal development. The pathway also has a prominent role in suppressing tumor growth, with the most evident contribution in HCC. In recent years, regulators of this pathway have gradually been revealed, providing new information for understanding this complex yet important growth-control signaling. This knowledge provides a basis for rational design of therapeutics against cancer that depends upon HippoYAP signaling for growth. © 2012 Informa UK, Ltd.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/etten_US
dc.relation.ispartofExpert Opinion on Therapeutic Targetsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCarcinoma, Hepatocellular - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshIntracellular Signaling Peptides And Proteins - Metabolismen_US
dc.subject.meshLiver Neoplasms - Metabolismen_US
dc.subject.meshNuclear Proteins - Metabolismen_US
dc.subject.meshProtein-Serine-Threonine Kinases - Metabolismen_US
dc.subject.meshSignal Transductionen_US
dc.subject.meshTranscription Factors - Metabolismen_US
dc.titleAn update on targeting Hippo-YAP signaling in liver canceren_US
dc.typeArticleen_US
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_US
dc.identifier.authorityLuk, JM=rp00349en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1517/14728222.2012.662958en_US
dc.identifier.pmid22335485en_US
dc.identifier.scopuseid_2-s2.0-84863298936en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863298936&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume16en_US
dc.identifier.issue3en_US
dc.identifier.spage243en_US
dc.identifier.epage247en_US
dc.identifier.isiWOS:000301456700002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLiu, AM=55276245300en_US
dc.identifier.scopusauthoridXu, Z=55276228500en_US
dc.identifier.scopusauthoridLuk, JM=7006777791en_US

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