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Article: Combinatorial use of bone morphogenetic protein 6, noggin and SOST significantly predicts cancer progression

TitleCombinatorial use of bone morphogenetic protein 6, noggin and SOST significantly predicts cancer progression
Authors
Issue Date2012
PublisherBlackwell Publishing Japan. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CAS
Citation
Cancer Science, 2012, v. 103 n. 6, p. 1145-1154 How to Cite?
AbstractEmerging evidence has indicated a role of the bone morphogenetic proteins (BMP) in the pathogenesis of certain cancers. The signaling of BMP family members is tightly regulated by their antagonists, including noggin and SOST, which are, in turn, positively regulated by BMP, thereby forming a negative feedback loop. Consequently, the expression of these antagonists should be taken into account in studies on the prognostic significance of BMP. In the present paper, we correlated protein and mRNA expression levels of BMP6, noggin and SOST, alone or in combination, with patient survival in various types of cancer. We found that BMP6 alone was not significantly correlated with esophageal squamous cell carcinoma patient survival. Instead, a high level of inhibitor of differentiation 1, a downstream factor of BMP6, was associated with shorter survival in patients whose tumors stained strongly for BMP6. Knockdown of noggin in esophageal cancer cell line EC109, which expresses BMP6 strongly and SOST weakly, enhanced the non-adherent growth of the cells. Noggin and SOST expression levels, when analyzed alone, were not significantly correlated with patient survival. However, high BMP6 activity, defined by strong BMP6 expression coupled with weak noggin or SOST expression, was significantly associated with shorter survival in esophageal squamous cell carcinoma patients. We further confirmed that BMP6 activity could be used as a prognostic indicator in prostate, bladder and colorectal cancers, using publicly available data on BMP6, noggin and SOST mRNA expression and patient survival. Our results strongly suggest that BMP6, noggin and SOST could be used in combination as a prognostic indicator in cancer progression. © 2012 Japanese Cancer Association.
Persistent Identifierhttp://hdl.handle.net/10722/173026
ISSN
2014 Impact Factor: 3.523
2014 SCImago Journal Rankings: 1.484
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, HFen_US
dc.contributor.authorMccrudden, CMen_US
dc.contributor.authorGrills, Cen_US
dc.contributor.authorZhang, SDen_US
dc.contributor.authorHuang, YHen_US
dc.contributor.authorChan, KKen_US
dc.contributor.authorChan, YPen_US
dc.contributor.authorWong, MLYen_US
dc.contributor.authorLaw, Sen_US
dc.contributor.authorSrivastava, Gen_US
dc.contributor.authorFennell, DAen_US
dc.contributor.authorDickson, Gen_US
dc.contributor.authorElTanani, Men_US
dc.contributor.authorChan, KWen_US
dc.date.accessioned2012-10-30T06:26:37Z-
dc.date.available2012-10-30T06:26:37Z-
dc.date.issued2012en_US
dc.identifier.citationCancer Science, 2012, v. 103 n. 6, p. 1145-1154en_US
dc.identifier.issn1347-9032en_US
dc.identifier.urihttp://hdl.handle.net/10722/173026-
dc.description.abstractEmerging evidence has indicated a role of the bone morphogenetic proteins (BMP) in the pathogenesis of certain cancers. The signaling of BMP family members is tightly regulated by their antagonists, including noggin and SOST, which are, in turn, positively regulated by BMP, thereby forming a negative feedback loop. Consequently, the expression of these antagonists should be taken into account in studies on the prognostic significance of BMP. In the present paper, we correlated protein and mRNA expression levels of BMP6, noggin and SOST, alone or in combination, with patient survival in various types of cancer. We found that BMP6 alone was not significantly correlated with esophageal squamous cell carcinoma patient survival. Instead, a high level of inhibitor of differentiation 1, a downstream factor of BMP6, was associated with shorter survival in patients whose tumors stained strongly for BMP6. Knockdown of noggin in esophageal cancer cell line EC109, which expresses BMP6 strongly and SOST weakly, enhanced the non-adherent growth of the cells. Noggin and SOST expression levels, when analyzed alone, were not significantly correlated with patient survival. However, high BMP6 activity, defined by strong BMP6 expression coupled with weak noggin or SOST expression, was significantly associated with shorter survival in esophageal squamous cell carcinoma patients. We further confirmed that BMP6 activity could be used as a prognostic indicator in prostate, bladder and colorectal cancers, using publicly available data on BMP6, noggin and SOST mRNA expression and patient survival. Our results strongly suggest that BMP6, noggin and SOST could be used in combination as a prognostic indicator in cancer progression. © 2012 Japanese Cancer Association.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Japan. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CASen_US
dc.relation.ispartofCancer Scienceen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshBone Morphogenetic Protein 6 - Genetics - Metabolismen_US
dc.subject.meshBone Morphogenetic Proteins - Genetics - Metabolismen_US
dc.subject.meshCarcinoma, Squamous Cell - Genetics - Mortalityen_US
dc.subject.meshCarrier Proteins - Genetics - Metabolismen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshColorectal Neoplasms - Metabolismen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshEsophageal Neoplasms - Genetics - Mortality - Pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Markers - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshInhibitor Of Differentiation Protein 1 - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProstatic Neoplasms - Metabolismen_US
dc.subject.meshRna Interferenceen_US
dc.subject.meshRna, Messenger - Genetics - Metabolismen_US
dc.subject.meshRna, Small Interferingen_US
dc.subject.meshSignal Transductionen_US
dc.subject.meshUrinary Bladder Neoplasms - Metabolismen_US
dc.titleCombinatorial use of bone morphogenetic protein 6, noggin and SOST significantly predicts cancer progressionen_US
dc.typeArticleen_US
dc.identifier.emailLaw, S: slaw@hku.hken_US
dc.identifier.emailSrivastava, G: gopesh@pathology.hku.hken_US
dc.identifier.emailChan, KW: hrmtckw@hku.hken_US
dc.identifier.authorityLaw, S=rp00437en_US
dc.identifier.authoritySrivastava, G=rp00365en_US
dc.identifier.authorityChan, KW=rp00330en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1349-7006.2012.02252.xen_US
dc.identifier.pmid22364398en_US
dc.identifier.scopuseid_2-s2.0-84861691253en_US
dc.identifier.hkuros206233-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84861691253&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume103en_US
dc.identifier.issue6en_US
dc.identifier.spage1145en_US
dc.identifier.epage1154en_US
dc.identifier.isiWOS:000304758200024-
dc.publisher.placeJapanen_US
dc.identifier.scopusauthoridYuen, HF=14018633400en_US
dc.identifier.scopusauthoridMccrudden, CM=16402813600en_US
dc.identifier.scopusauthoridGrills, C=15843350400en_US
dc.identifier.scopusauthoridZhang, SD=49061648600en_US
dc.identifier.scopusauthoridHuang, YH=53877504400en_US
dc.identifier.scopusauthoridChan, KK=55234810900en_US
dc.identifier.scopusauthoridChan, YP=14009821700en_US
dc.identifier.scopusauthoridWong, MLY=37021112700en_US
dc.identifier.scopusauthoridLaw, S=7202241293en_US
dc.identifier.scopusauthoridSrivastava, G=7202242238en_US
dc.identifier.scopusauthoridFennell, DA=54903246000en_US
dc.identifier.scopusauthoridDickson, G=55235953600en_US
dc.identifier.scopusauthoridElTanani, M=6602759648en_US
dc.identifier.scopusauthoridChan, KW=16444133100en_US

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