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Article: The impact of family history of hepatocellular carcinoma on its patients' survival

TitleThe impact of family history of hepatocellular carcinoma on its patients' survival
Authors
KeywordsFamily History
Hepatocellular Carcinoma
Resection
Risk Factor
Survival
Issue Date2012
PublisherThe First Affiliated Hospital, Zhejiang University School of Medicine. The Journal's web site is located at http://www.hbpdint.com/
Citation
Hepatobiliary And Pancreatic Diseases International, 2012, v. 11 n. 2, p. 160-164 How to Cite?
AbstractBACKGROUND: Family history of hepatocellular carcinoma (HCC) has been identified as a risk factor for the development of the disease. The aim of this study is to evaluate the impact of such a history on HCC patients' survival. METHODS: Data of all HCC patients (n=4532) managed at our center from 1989 to 2008 were prospectively collected. The patients were quizzed on their various characteristics including family HCC history. RESULTS: Totally 475 (10.48%) patients had a family history of HCC. They presented the disease at a significantly earlier age (median 53 vs 59 years, P<0.0001) and at an earlier stage (the United Network for Organ Sharing staging system). They had significantly better liver function in terms of Child- Pugh classification and serum albumin and bilirubin levels. Significantly more of them presented the disease without symptoms (44.0% vs 29.4%, P<0.0001). They also had significantly better overall survival under these specifications: patients in the whole study cohort, patients who had minor hepatectomy, patients with stage I disease, patients with stage II disease, and patients with stage III disease. CONCLUSIONS: Contrary to what is generally believed, we found in this study cohort that patients with a family history of HCC had better overall survival than those without such a history. We believe this was in part due to earlier diagnosis of the disease and better liver function in this group of patients. However, the effects of genetic factors on the risk of HCC cannot be overlooked and are yet to be identified. © 2012, Hepatobiliary Pancreat Dis Int.
Persistent Identifierhttp://hdl.handle.net/10722/173022
ISSN
2015 Impact Factor: 1.724
2015 SCImago Journal Rankings: 0.717
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDai, WCen_US
dc.contributor.authorFan, STen_US
dc.contributor.authorCheung, TTen_US
dc.contributor.authorChok, KSHen_US
dc.contributor.authorChan, ACYen_US
dc.contributor.authorTsang, SHYen_US
dc.contributor.authorPoon, RTPen_US
dc.contributor.authorLo, CMen_US
dc.date.accessioned2012-10-30T06:26:35Z-
dc.date.available2012-10-30T06:26:35Z-
dc.date.issued2012en_US
dc.identifier.citationHepatobiliary And Pancreatic Diseases International, 2012, v. 11 n. 2, p. 160-164en_US
dc.identifier.issn1499-3872en_US
dc.identifier.urihttp://hdl.handle.net/10722/173022-
dc.description.abstractBACKGROUND: Family history of hepatocellular carcinoma (HCC) has been identified as a risk factor for the development of the disease. The aim of this study is to evaluate the impact of such a history on HCC patients' survival. METHODS: Data of all HCC patients (n=4532) managed at our center from 1989 to 2008 were prospectively collected. The patients were quizzed on their various characteristics including family HCC history. RESULTS: Totally 475 (10.48%) patients had a family history of HCC. They presented the disease at a significantly earlier age (median 53 vs 59 years, P<0.0001) and at an earlier stage (the United Network for Organ Sharing staging system). They had significantly better liver function in terms of Child- Pugh classification and serum albumin and bilirubin levels. Significantly more of them presented the disease without symptoms (44.0% vs 29.4%, P<0.0001). They also had significantly better overall survival under these specifications: patients in the whole study cohort, patients who had minor hepatectomy, patients with stage I disease, patients with stage II disease, and patients with stage III disease. CONCLUSIONS: Contrary to what is generally believed, we found in this study cohort that patients with a family history of HCC had better overall survival than those without such a history. We believe this was in part due to earlier diagnosis of the disease and better liver function in this group of patients. However, the effects of genetic factors on the risk of HCC cannot be overlooked and are yet to be identified. © 2012, Hepatobiliary Pancreat Dis Int.en_US
dc.languageengen_US
dc.publisherThe First Affiliated Hospital, Zhejiang University School of Medicine. The Journal's web site is located at http://www.hbpdint.com/en_US
dc.relation.ispartofHepatobiliary and Pancreatic Diseases Internationalen_US
dc.subjectFamily Historyen_US
dc.subjectHepatocellular Carcinomaen_US
dc.subjectResectionen_US
dc.subjectRisk Factoren_US
dc.subjectSurvivalen_US
dc.titleThe impact of family history of hepatocellular carcinoma on its patients' survivalen_US
dc.typeArticleen_US
dc.identifier.emailFan, ST: stfan@hku.hken_US
dc.identifier.emailChan, ACY: acchan@hku.hken_US
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_US
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_US
dc.identifier.emailCheung, TT: cheung68@hku.hk-
dc.identifier.authorityFan, ST=rp00355en_US
dc.identifier.authorityChan, ACY=rp00310en_US
dc.identifier.authorityPoon, RTP=rp00446en_US
dc.identifier.authorityLo, CM=rp00412en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1016/s1499-3872(12)60142-8en_US
dc.identifier.pmid22484584-
dc.identifier.scopuseid_2-s2.0-84859827108en_US
dc.identifier.hkuros211071-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84859827108&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume11en_US
dc.identifier.issue2en_US
dc.identifier.spage160en_US
dc.identifier.epage164en_US
dc.identifier.isiWOS:000302762500008-
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridDai, WC=36186690700en_US
dc.identifier.scopusauthoridFan, ST=7402678224en_US
dc.identifier.scopusauthoridCheung, TT=7103334165en_US
dc.identifier.scopusauthoridChok, KSH=6508229426en_US
dc.identifier.scopusauthoridChan, ACY=15828849100en_US
dc.identifier.scopusauthoridTsang, SHY=7102255986en_US
dc.identifier.scopusauthoridPoon, RTP=7103097223en_US
dc.identifier.scopusauthoridLo, CM=7401771672en_US

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