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- Publisher Website: 10.1016/j.drudis.2009.05.005
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- PMID: 19477290
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Article: New tools for functional genomic analysis
Title | New tools for functional genomic analysis |
---|---|
Authors | |
Issue Date | 2009 |
Publisher | Elsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/drugdiscov |
Citation | Drug Discovery Today, 2009, v. 14 n. 15-16, p. 754-760 How to Cite? |
Abstract | For the past decade, the development of genomic technology has revolutionized modern biological research and drug discovery. Functional genomic analyses enable biologists to perform analysis of genetic events on a global scale and they have been widely used in gene discovery, biomarker determination, disease classification, and drug target identification. In this article, we provide an overview of the current and emerging tools involved in genomic studies, including expression arrays, microRNA arrays, array CGH, ChIP-on-chip, methylation arrays, mutation analysis, genome-wide association studies, proteomic analysis, integrated functional genomic analysis and related bioinformatic and biostatistical analyses. Using human liver cancer as an example, we provide further information of how these genomic approaches can be applied in cancer research. © 2009 Elsevier Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/172991 |
ISSN | 2021 Impact Factor: 8.369 2020 SCImago Journal Rankings: 1.778 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chen, X | en_US |
dc.contributor.author | Jorgenson, E | en_US |
dc.contributor.author | Cheung, ST | en_US |
dc.date.accessioned | 2012-10-30T06:26:15Z | - |
dc.date.available | 2012-10-30T06:26:15Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Drug Discovery Today, 2009, v. 14 n. 15-16, p. 754-760 | en_US |
dc.identifier.issn | 1359-6446 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/172991 | - |
dc.description.abstract | For the past decade, the development of genomic technology has revolutionized modern biological research and drug discovery. Functional genomic analyses enable biologists to perform analysis of genetic events on a global scale and they have been widely used in gene discovery, biomarker determination, disease classification, and drug target identification. In this article, we provide an overview of the current and emerging tools involved in genomic studies, including expression arrays, microRNA arrays, array CGH, ChIP-on-chip, methylation arrays, mutation analysis, genome-wide association studies, proteomic analysis, integrated functional genomic analysis and related bioinformatic and biostatistical analyses. Using human liver cancer as an example, we provide further information of how these genomic approaches can be applied in cancer research. © 2009 Elsevier Ltd. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Ltd, Trends Journals. The Journal's web site is located at http://www.elsevier.com/locate/drugdiscov | en_US |
dc.relation.ispartof | Drug Discovery Today | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Biological Markers - Analysis | en_US |
dc.subject.mesh | Biomedical Research - Methods | en_US |
dc.subject.mesh | Drug Delivery Systems | en_US |
dc.subject.mesh | Drug Discovery - Methods | en_US |
dc.subject.mesh | Genomics - Methods | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Liver Neoplasms - Genetics | en_US |
dc.subject.mesh | Micrornas - Metabolism | en_US |
dc.subject.mesh | Oligonucleotide Array Sequence Analysis - Methods | en_US |
dc.subject.mesh | Proteomics - Methods | en_US |
dc.title | New tools for functional genomic analysis | en_US |
dc.type | Article | en_US |
dc.identifier.email | Cheung, ST: stcheung@hkucc.hku.hk | en_US |
dc.identifier.authority | Cheung, ST=rp00457 | en_US |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.doi | 10.1016/j.drudis.2009.05.005 | en_US |
dc.identifier.pmid | 19477290 | - |
dc.identifier.scopus | eid_2-s2.0-67651233521 | en_US |
dc.identifier.hkuros | 164795 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-67651233521&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 14 | en_US |
dc.identifier.issue | 15-16 | en_US |
dc.identifier.spage | 754 | en_US |
dc.identifier.epage | 760 | en_US |
dc.identifier.isi | WOS:000269243000005 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Chen, X=8978110800 | en_US |
dc.identifier.scopusauthorid | Jorgenson, E=6602739187 | en_US |
dc.identifier.scopusauthorid | Cheung, ST=7202473497 | en_US |
dc.identifier.citeulike | 4745321 | - |
dc.identifier.issnl | 1359-6446 | - |