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Article: Thyroid dysfunction in laryngectomees - 10 years after treatment

TitleThyroid dysfunction in laryngectomees - 10 years after treatment
Authors
Issue Date2008
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137
Citation
Head And Neck, 2008, v. 30 n. 3, p. 336-340 How to Cite?
AbstractBackground. Hypothyroidism is 1 of the complications that follow treatment of various head and neck cancers. In the literature, reviews using different primary sites and differences in treatment modalities make comparison of post-treatment hypothyroidism not possible. The objective of this study was to evaluate the incidence of hypothyroidism in a homogenous group of patients who were treated with total laryngectomy and irradiation for laryngeal carcinoma and to assess the importance of different variables in the occurrence of hypothyroidism. Methods. A retrospective review of 147 total laryngectomy patients between 1993 and 2003 was carried out. Serum thyroxine level and free T4 levels were assessed in all patients. Hypothyroidism was classified as subclinical (increased thyroid-stimulating hormone and normal free T4 levels) and clinical (increased thyroid-stimulating hormone and decreased free T4 levels). Results. The results showed that the overall incidence of hypothyroidism was 49% (44% subclinical and 5% clinical). Hemithyroidectomy and advanced tumor staging were risk factors for the development of hypothyroidism in these patients (p < .05) with a relative risk of 2.1 (CI 95%, 1.4-3.1) and 1.3 (CI 95%, 1.1-1.6), respectively. During follow-up, 19.9% of patients developed hypothyroidism at 3 years, 38.6% at 6 years; at 10 year follow-up, 93.3% of them had hypothyroidism. Conclusions. In conclusion, hypothyroidism is a frequent complication in patients treated with radiotherapy and total laryngectomy for laryngeal cancer, especially when treatment includes hemithyroidectomy. These patients should have their thyroid function evaluated periodically even 10 years after treatment. ©2007 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/172962
ISSN
2015 Impact Factor: 2.76
2015 SCImago Journal Rankings: 1.233
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, ACWen_US
dc.contributor.authorHo, WKen_US
dc.contributor.authorLam, PKYen_US
dc.contributor.authorYuen, APWen_US
dc.contributor.authorWei, WIen_US
dc.date.accessioned2012-10-30T06:26:04Z-
dc.date.available2012-10-30T06:26:04Z-
dc.date.issued2008en_US
dc.identifier.citationHead And Neck, 2008, v. 30 n. 3, p. 336-340en_US
dc.identifier.issn1043-3074en_US
dc.identifier.urihttp://hdl.handle.net/10722/172962-
dc.description.abstractBackground. Hypothyroidism is 1 of the complications that follow treatment of various head and neck cancers. In the literature, reviews using different primary sites and differences in treatment modalities make comparison of post-treatment hypothyroidism not possible. The objective of this study was to evaluate the incidence of hypothyroidism in a homogenous group of patients who were treated with total laryngectomy and irradiation for laryngeal carcinoma and to assess the importance of different variables in the occurrence of hypothyroidism. Methods. A retrospective review of 147 total laryngectomy patients between 1993 and 2003 was carried out. Serum thyroxine level and free T4 levels were assessed in all patients. Hypothyroidism was classified as subclinical (increased thyroid-stimulating hormone and normal free T4 levels) and clinical (increased thyroid-stimulating hormone and decreased free T4 levels). Results. The results showed that the overall incidence of hypothyroidism was 49% (44% subclinical and 5% clinical). Hemithyroidectomy and advanced tumor staging were risk factors for the development of hypothyroidism in these patients (p < .05) with a relative risk of 2.1 (CI 95%, 1.4-3.1) and 1.3 (CI 95%, 1.1-1.6), respectively. During follow-up, 19.9% of patients developed hypothyroidism at 3 years, 38.6% at 6 years; at 10 year follow-up, 93.3% of them had hypothyroidism. Conclusions. In conclusion, hypothyroidism is a frequent complication in patients treated with radiotherapy and total laryngectomy for laryngeal cancer, especially when treatment includes hemithyroidectomy. These patients should have their thyroid function evaluated periodically even 10 years after treatment. ©2007 Wiley Periodicals, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137en_US
dc.relation.ispartofHead and Necken_US
dc.subject.meshAgeden_US
dc.subject.meshAntineoplastic Agents - Therapeutic Useen_US
dc.subject.meshChemotherapy, Adjuvanten_US
dc.subject.meshCisplatin - Therapeutic Useen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshHypothyroidism - Epidemiology - Etiologyen_US
dc.subject.meshLaryngeal Neoplasms - Pathology - Therapyen_US
dc.subject.meshLaryngectomy - Adverse Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMultivariate Analysisen_US
dc.subject.meshRadiotherapy, Adjuvanten_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshThyroidectomy - Adverse Effects - Methodsen_US
dc.titleThyroid dysfunction in laryngectomees - 10 years after treatmenten_US
dc.typeArticleen_US
dc.identifier.emailWei, WI: hrmswwi@hku.hken_US
dc.identifier.authorityWei, WI=rp00323en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/hed.20693en_US
dc.identifier.pmid17636544-
dc.identifier.scopuseid_2-s2.0-41649103972en_US
dc.identifier.hkuros131914-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-41649103972&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume30en_US
dc.identifier.issue3en_US
dc.identifier.spage336en_US
dc.identifier.epage340en_US
dc.identifier.isiWOS:000253962300008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHo, ACW=16202695800en_US
dc.identifier.scopusauthoridHo, WK=7402968844en_US
dc.identifier.scopusauthoridLam, PKY=7202366058en_US
dc.identifier.scopusauthoridYuen, APW=7006290111en_US
dc.identifier.scopusauthoridWei, WI=7403321552en_US

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