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Article: Craniofacial surgery for nonmelanoma skin malignancy: Report of an international collaborative study

TitleCraniofacial surgery for nonmelanoma skin malignancy: Report of an international collaborative study
Authors
Issue Date2007
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137
Citation
Head And Neck, 2007, v. 29 n. 12, p. 1136-1143 How to Cite?
AbstractBackground. This study examined the efficacy of craniofacial surgery (CFS) in treating locally advanced nonmelanoma skin cancer (NMSC). Methods. One hundred twenty patients who underwent CFS for NMSC were identified from 17 participating institutions. Patient, tumor, and treatment information was analyzed for prognostic impact on survival. Results. Surgical margins were negative in 74%, close in 3%, and involved in 23% of patients. Complications occurred in 35% of patients, half of which were local wound problems. Operative mortality was 4%. Median follow-up interval after CFS was 27 months. The 5-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) rates were 64%, 75%, and 60%, respectively. Squamous cell histology, brain invasion, and positive resection margins independently predicted worse OS, DSS, and RFS. Conclusion. CFS is an effective treatment for patients with NMSC invading the skull base. Histology, extent of disease, and resection margins are the most significant predictors of outcome. © 2007 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/172954
ISSN
2015 Impact Factor: 2.76
2015 SCImago Journal Rankings: 1.233
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMaghami, EGen_US
dc.contributor.authorTalbot, SGen_US
dc.contributor.authorPatel, SGen_US
dc.contributor.authorSingh, Ben_US
dc.contributor.authorPolluri, Aen_US
dc.contributor.authorBridger, PGen_US
dc.contributor.authorCantu, Gen_US
dc.contributor.authorCheesman, ADen_US
dc.contributor.authorDe Sa, Gen_US
dc.contributor.authorDonald, Pen_US
dc.contributor.authorDos Santos, LRMen_US
dc.contributor.authorFliss, Den_US
dc.contributor.authorGullane, Pen_US
dc.contributor.authorJanecka, Ien_US
dc.contributor.authorKamata, SEen_US
dc.contributor.authorKowalski, LPen_US
dc.contributor.authorKraus, DHen_US
dc.contributor.authorLevine, PAen_US
dc.contributor.authorPradhan, Sen_US
dc.contributor.authorSchramm, Ven_US
dc.contributor.authorSnyderman, Cen_US
dc.contributor.authorWei, WIen_US
dc.contributor.authorShah, JPen_US
dc.date.accessioned2012-10-30T06:26:01Z-
dc.date.available2012-10-30T06:26:01Z-
dc.date.issued2007en_US
dc.identifier.citationHead And Neck, 2007, v. 29 n. 12, p. 1136-1143en_US
dc.identifier.issn1043-3074en_US
dc.identifier.urihttp://hdl.handle.net/10722/172954-
dc.description.abstractBackground. This study examined the efficacy of craniofacial surgery (CFS) in treating locally advanced nonmelanoma skin cancer (NMSC). Methods. One hundred twenty patients who underwent CFS for NMSC were identified from 17 participating institutions. Patient, tumor, and treatment information was analyzed for prognostic impact on survival. Results. Surgical margins were negative in 74%, close in 3%, and involved in 23% of patients. Complications occurred in 35% of patients, half of which were local wound problems. Operative mortality was 4%. Median follow-up interval after CFS was 27 months. The 5-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) rates were 64%, 75%, and 60%, respectively. Squamous cell histology, brain invasion, and positive resection margins independently predicted worse OS, DSS, and RFS. Conclusion. CFS is an effective treatment for patients with NMSC invading the skull base. Histology, extent of disease, and resection margins are the most significant predictors of outcome. © 2007 Wiley Periodicals, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137en_US
dc.relation.ispartofHead and Necken_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshBrain Neoplasms - Mortality - Secondary - Surgeryen_US
dc.subject.meshCarcinoma, Basal Cell - Mortality - Pathology - Surgeryen_US
dc.subject.meshCarcinoma, Squamous Cell - Mortality - Pathology - Surgeryen_US
dc.subject.meshChemotherapy, Adjuvanten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDisease-Free Survivalen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshInternational Cooperationen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Invasivenessen_US
dc.subject.meshPostoperative Complicationsen_US
dc.subject.meshRadiotherapy, Adjuvanten_US
dc.subject.meshSkin Neoplasms - Mortality - Pathology - Surgeryen_US
dc.subject.meshSkull Neoplasms - Mortality - Secondary - Surgeryen_US
dc.subject.meshSurgical Flapsen_US
dc.titleCraniofacial surgery for nonmelanoma skin malignancy: Report of an international collaborative studyen_US
dc.typeArticleen_US
dc.identifier.emailWei, WI: hrmswwi@hku.hken_US
dc.identifier.authorityWei, WI=rp00323en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/hed.20656en_US
dc.identifier.pmid17764086-
dc.identifier.scopuseid_2-s2.0-38049004380en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38049004380&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume29en_US
dc.identifier.issue12en_US
dc.identifier.spage1136en_US
dc.identifier.epage1143en_US
dc.identifier.isiWOS:000251539700010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMaghami, EG=10045598700en_US
dc.identifier.scopusauthoridTalbot, SG=7102399057en_US
dc.identifier.scopusauthoridPatel, SG=7403903141en_US
dc.identifier.scopusauthoridSingh, B=7405639360en_US
dc.identifier.scopusauthoridPolluri, A=6505641537en_US
dc.identifier.scopusauthoridBridger, PG=6603845621en_US
dc.identifier.scopusauthoridCantu, G=7003498793en_US
dc.identifier.scopusauthoridCheesman, AD=7003676128en_US
dc.identifier.scopusauthoridDe Sa, G=8561754500en_US
dc.identifier.scopusauthoridDonald, P=7103189603en_US
dc.identifier.scopusauthoridDos Santos, LRM=7005029659en_US
dc.identifier.scopusauthoridFliss, D=7005455625en_US
dc.identifier.scopusauthoridGullane, P=7005484642en_US
dc.identifier.scopusauthoridJanecka, I=7005569375en_US
dc.identifier.scopusauthoridKamata, SE=35478208000en_US
dc.identifier.scopusauthoridKowalski, LP=7102126040en_US
dc.identifier.scopusauthoridKraus, DH=25947461900en_US
dc.identifier.scopusauthoridLevine, PA=35386674700en_US
dc.identifier.scopusauthoridPradhan, S=7202877432en_US
dc.identifier.scopusauthoridSchramm, V=35511790400en_US
dc.identifier.scopusauthoridSnyderman, C=7005989580en_US
dc.identifier.scopusauthoridWei, WI=7403321552en_US
dc.identifier.scopusauthoridShah, JP=7403266008en_US

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