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Article: Oncoproteomics of hepatocellular carcinoma: From cancer markers' discovery to functional pathways

TitleOncoproteomics of hepatocellular carcinoma: From cancer markers' discovery to functional pathways
Authors
Issue Date2007
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1478-3223&site=1
Citation
Liver International, 2007, v. 27 n. 8, p. 1021-1038 How to Cite?
AbstractHepatocellular carcinoma (HCC) is a heterogeneous cancer with no promising treatment and remains one of the most prevailing and lethal malignancies in the world. Researchers in many biological areas now routinely identify and characterize protein markers by a mass spectrometry-based proteomic approach, a method that has been commonly used to discover diagnostic biomarkers for cancer detection. The proteomic research platforms span from the classical two-dimensional polyacrylamide gel electrophoresis (2-DE) to the latest Protein Chip or array technology, which are often integrated with the MALDI (matrix-assisted laser-desorption ionization), SELDI (surface-enhanced laser desorption/ionization) or tandem mass spectrometry (MS/MS). New advances on quantitative proteomic analysis (e.g. SILAC, ICAT, and ITRAQ) and multidimensional protein identification technology (MudPIT) have greatly enhanced the capability of proteomic methods to study the expressions, modifications and functions of protein markers. The present article reviews the latest proteomic development and discovery of biomarkers in HCC that may provide insights into the underlying mechanisms of hepatocarcinogenesis and the readiness of biomarkers for clinical uses. © 2007 Blackwell Munksgaard.
Persistent Identifierhttp://hdl.handle.net/10722/172948
ISSN
2015 Impact Factor: 4.47
2015 SCImago Journal Rankings: 1.677
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSun, Sen_US
dc.contributor.authorLee, NPYen_US
dc.contributor.authorPoon, RTPen_US
dc.contributor.authorFan, STen_US
dc.contributor.authorHe, QYen_US
dc.contributor.authorLau, GKen_US
dc.contributor.authorLuk, JMen_US
dc.date.accessioned2012-10-30T06:25:57Z-
dc.date.available2012-10-30T06:25:57Z-
dc.date.issued2007en_US
dc.identifier.citationLiver International, 2007, v. 27 n. 8, p. 1021-1038en_US
dc.identifier.issn1478-3223en_US
dc.identifier.urihttp://hdl.handle.net/10722/172948-
dc.description.abstractHepatocellular carcinoma (HCC) is a heterogeneous cancer with no promising treatment and remains one of the most prevailing and lethal malignancies in the world. Researchers in many biological areas now routinely identify and characterize protein markers by a mass spectrometry-based proteomic approach, a method that has been commonly used to discover diagnostic biomarkers for cancer detection. The proteomic research platforms span from the classical two-dimensional polyacrylamide gel electrophoresis (2-DE) to the latest Protein Chip or array technology, which are often integrated with the MALDI (matrix-assisted laser-desorption ionization), SELDI (surface-enhanced laser desorption/ionization) or tandem mass spectrometry (MS/MS). New advances on quantitative proteomic analysis (e.g. SILAC, ICAT, and ITRAQ) and multidimensional protein identification technology (MudPIT) have greatly enhanced the capability of proteomic methods to study the expressions, modifications and functions of protein markers. The present article reviews the latest proteomic development and discovery of biomarkers in HCC that may provide insights into the underlying mechanisms of hepatocarcinogenesis and the readiness of biomarkers for clinical uses. © 2007 Blackwell Munksgaard.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1478-3223&site=1en_US
dc.relation.ispartofLiver Internationalen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCarcinoma, Hepatocellular - Blood - Chemistry - Diagnosisen_US
dc.subject.meshElectrophoresis, Gel, Two-Dimensionalen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Neoplasms - Blood - Chemistry - Diagnosisen_US
dc.subject.meshNeoplasm Proteins - Analysis - Blooden_US
dc.subject.meshProtein Array Analysisen_US
dc.subject.meshProteomics - Methods - Trendsen_US
dc.subject.meshSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionizationen_US
dc.subject.meshTandem Mass Spectrometryen_US
dc.subject.meshTumor Markers, Biological - Analysis - Blooden_US
dc.titleOncoproteomics of hepatocellular carcinoma: From cancer markers' discovery to functional pathwaysen_US
dc.typeArticleen_US
dc.identifier.emailLee, NPY: nikkilee@hku.hken_US
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_US
dc.identifier.emailFan, ST: stfan@hku.hken_US
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_US
dc.identifier.authorityLee, NPY=rp00263en_US
dc.identifier.authorityPoon, RTP=rp00446en_US
dc.identifier.authorityFan, ST=rp00355en_US
dc.identifier.authorityLuk, JM=rp00349en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1111/j.1478-3231.2007.01533.xen_US
dc.identifier.pmid17845530-
dc.identifier.scopuseid_2-s2.0-34548640225en_US
dc.identifier.hkuros137597-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548640225&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume27en_US
dc.identifier.issue8en_US
dc.identifier.spage1021en_US
dc.identifier.epage1038en_US
dc.identifier.isiWOS:000249433200001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSun, S=21740136100en_US
dc.identifier.scopusauthoridLee, NPY=7402722690en_US
dc.identifier.scopusauthoridPoon, RTP=7103097223en_US
dc.identifier.scopusauthoridFan, ST=7402678224en_US
dc.identifier.scopusauthoridHe, QY=34770287900en_US
dc.identifier.scopusauthoridLau, GK=7102301257en_US
dc.identifier.scopusauthoridLuk, JM=7006777791en_US
dc.identifier.citeulike1641817-

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