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Article: Use of MARS in hepatorenal syndrome - A local perspective

TitleUse of MARS in hepatorenal syndrome - A local perspective
Authors
KeywordsHepatorenal Syndrome
Liver Failure
Mars
Molecular Adsorbent Recirculation System
Issue Date2006
PublisherLippincott Williams & Wilkins Asia. The Journal's web site is located at http://www.hkjn.org/
Citation
Hong Kong Journal Of Nephrology, 2006, v. 8 n. 1, p. 5-9 How to Cite?
AbstractHepatorenal syndrome is a complication of liver failure with high mortality. All existing treatments, short of liver transplantation, can only be considered as supportive. The molecular adsorbent recirculation system (MARS) is a modified dialysis technique that can remove bilirubin and other albumin-bound toxins, and is now widely used as an artificial liver support system. MARS has been evaluated in many studies, although most have been observational rather than randomized controlled trials. MARS has been demonstrated to be effective in attenuating serum bilirubin, ammonia, creatinine and other hepatotoxin levels in patients, but the biochemical improvement has not been accompanied by an improvement in patient survival. Factors that affect the outcome of patients include timing of implementation, nature of the liver diseases treated, and availability of liver transplantation. MARS preconditioning is another possible indication that aims to improve the postoperative outcome in elective live donor liver transplantation. In the future, randomized controlled trials will be necessary to ascertain the specific role of MARS in the management of liver failure.
Persistent Identifierhttp://hdl.handle.net/10722/172910
ISSN
2015 SCImago Journal Rankings: 0.166
References

 

DC FieldValueLanguage
dc.contributor.authorChiu, Aen_US
dc.contributor.authorFan, STen_US
dc.date.accessioned2012-10-30T06:25:45Z-
dc.date.available2012-10-30T06:25:45Z-
dc.date.issued2006en_US
dc.identifier.citationHong Kong Journal Of Nephrology, 2006, v. 8 n. 1, p. 5-9en_US
dc.identifier.issn1561-5413en_US
dc.identifier.urihttp://hdl.handle.net/10722/172910-
dc.description.abstractHepatorenal syndrome is a complication of liver failure with high mortality. All existing treatments, short of liver transplantation, can only be considered as supportive. The molecular adsorbent recirculation system (MARS) is a modified dialysis technique that can remove bilirubin and other albumin-bound toxins, and is now widely used as an artificial liver support system. MARS has been evaluated in many studies, although most have been observational rather than randomized controlled trials. MARS has been demonstrated to be effective in attenuating serum bilirubin, ammonia, creatinine and other hepatotoxin levels in patients, but the biochemical improvement has not been accompanied by an improvement in patient survival. Factors that affect the outcome of patients include timing of implementation, nature of the liver diseases treated, and availability of liver transplantation. MARS preconditioning is another possible indication that aims to improve the postoperative outcome in elective live donor liver transplantation. In the future, randomized controlled trials will be necessary to ascertain the specific role of MARS in the management of liver failure.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins Asia. The Journal's web site is located at http://www.hkjn.org/en_US
dc.relation.ispartofHong Kong Journal of Nephrologyen_US
dc.subjectHepatorenal Syndromeen_US
dc.subjectLiver Failureen_US
dc.subjectMarsen_US
dc.subjectMolecular Adsorbent Recirculation Systemen_US
dc.titleUse of MARS in hepatorenal syndrome - A local perspectiveen_US
dc.typeArticleen_US
dc.identifier.emailFan, ST: stfan@hku.hken_US
dc.identifier.authorityFan, ST=rp00355en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S1561-5413(09)60223-4-
dc.identifier.scopuseid_2-s2.0-33646257091en_US
dc.identifier.hkuros116850-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646257091&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume8en_US
dc.identifier.issue1en_US
dc.identifier.spage5en_US
dc.identifier.epage9en_US
dc.publisher.placeHong Kongen_US
dc.identifier.scopusauthoridChiu, A=35721752900en_US
dc.identifier.scopusauthoridFan, ST=7402678224en_US

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