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Article: Olfactory neuroblastoma: Past, present, and future?

TitleOlfactory neuroblastoma: Past, present, and future?
Authors
Issue Date2003
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.laryngoscope.com/
Citation
Laryngoscope, 2003, v. 113 n. 3, p. 502-507 How to Cite?
AbstractObjective: To consider the long-term survival and outcomes in patients with olfactory neuroblastoma undergoing craniofacial resection. Study Design: A single-center prospective cohort study. Methods: All patients with olfactory neuroblastoma treated in a 23-year period with craniofacial resection (with or without radiotherapy) were analyzed; a multivariate analysis was included. Results: Forty-two patients aged 12 to 70 years were assessed, 83% of whom had received no preceding treatment. Craniofacial resection was used in all cases, combined with radiotherapy in 24 patients (57%). Duration of follow-up ranged from 2 to 206 months (mean follow-up period, 57 mo). The disease-free actuarial survival and overall survival were 77% and 61% at 5 years and 53% and 42% at 10 years, respectively. A Cox regression analysis identified intracranial extension and orbital involvement as independent factors affecting outcome. Conclusion: Craniofacial resection combined with radiotherapy offers the gold standard of care against which other approaches such as endoscopic resection must be judged.
Persistent Identifierhttp://hdl.handle.net/10722/172823
ISSN
2015 Impact Factor: 2.272
2015 SCImago Journal Rankings: 1.342
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLund, VJen_US
dc.contributor.authorHoward, Den_US
dc.contributor.authorWei, Wen_US
dc.contributor.authorSpittle, Men_US
dc.date.accessioned2012-10-30T06:25:07Z-
dc.date.available2012-10-30T06:25:07Z-
dc.date.issued2003en_US
dc.identifier.citationLaryngoscope, 2003, v. 113 n. 3, p. 502-507en_US
dc.identifier.issn0023-852Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/172823-
dc.description.abstractObjective: To consider the long-term survival and outcomes in patients with olfactory neuroblastoma undergoing craniofacial resection. Study Design: A single-center prospective cohort study. Methods: All patients with olfactory neuroblastoma treated in a 23-year period with craniofacial resection (with or without radiotherapy) were analyzed; a multivariate analysis was included. Results: Forty-two patients aged 12 to 70 years were assessed, 83% of whom had received no preceding treatment. Craniofacial resection was used in all cases, combined with radiotherapy in 24 patients (57%). Duration of follow-up ranged from 2 to 206 months (mean follow-up period, 57 mo). The disease-free actuarial survival and overall survival were 77% and 61% at 5 years and 53% and 42% at 10 years, respectively. A Cox regression analysis identified intracranial extension and orbital involvement as independent factors affecting outcome. Conclusion: Craniofacial resection combined with radiotherapy offers the gold standard of care against which other approaches such as endoscopic resection must be judged.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.laryngoscope.com/en_US
dc.relation.ispartofLaryngoscopeen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshChilden_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshEsthesioneuroblastoma, Olfactory - Pathology - Radiotherapy - Surgeryen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMultivariate Analysisen_US
dc.subject.meshNasal Cavity - Pathology - Radiation Effects - Surgeryen_US
dc.subject.meshNose Neoplasms - Pathology - Radiotherapy - Surgeryen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSurgical Procedures, Operative - Methodsen_US
dc.subject.meshSurvivorsen_US
dc.titleOlfactory neuroblastoma: Past, present, and future?en_US
dc.typeArticleen_US
dc.identifier.emailWei, W: hrmswwi@hku.hken_US
dc.identifier.authorityWei, W=rp00323en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00005537-200303000-00020en_US
dc.identifier.pmid12616204-
dc.identifier.scopuseid_2-s2.0-0037337242en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037337242&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume113en_US
dc.identifier.issue3en_US
dc.identifier.spage502en_US
dc.identifier.epage507en_US
dc.identifier.isiWOS:000181389300020-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLund, VJ=7102840344en_US
dc.identifier.scopusauthoridHoward, D=7202305361en_US
dc.identifier.scopusauthoridWei, W=7403321552en_US
dc.identifier.scopusauthoridSpittle, M=7005469643en_US

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