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Article: Ultrasonic analysis of plaque characteristics and intimal-medial thickness in radiation-induced atherosclerotic carotid arteries

TitleUltrasonic analysis of plaque characteristics and intimal-medial thickness in radiation-induced atherosclerotic carotid arteries
Authors
Issue Date2002
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejvs
Citation
European Journal Of Vascular And Endovascular Surgery, 2002, v. 24 n. 6, p. 499-504 How to Cite?
AbstractObjectives: to investigate the effect of external irradiation on the morphology of atherosclerotic plaques and the intimal-medial thickness of the carotid artery. Methods: a group of 46 patients (16 symptomatic) who had received external irradiation to the head and neck area more than five years previously and developed carotid stenosis exceeding 50%, were evaluated by duplex ultrasound. The carotid artery lumen, intimal-medial complex, and the plaque echogenicity was determined using computer digital image processing methods, forty-six age and sex matched patients with similar degrees of non-radiation associated carotid stenosis were used as controls. Results: irradiated stenotic carotid arteries had a greater intimal-medial thickness (0.96 mm vs 0.80 mm, p = 0.008) and a narrower lumen (5.5 mm vs 6.6 mm, p < 0.002) than the controls. The carotid plaque characteristics (gray-scale median (GSM) and heterogeneity) of the irradiated and control groups did not differ significantly. Symptomatic patients who had received external radiotherapy to the head and neck have a more echolucent plaque (mean GSM of 98) than their asymptomatic counterparts (mean GSM 114, p = 0.03). Intimal-medial thickness and carotid lumen was not related to the occurrence of symptoms. Conclusions: external irradiation to the head and neck area leads to significantly increased thickness of the carotid wall and a corresponding narrowing of the lumen. There seems to be no difference in the plaque characteristics between irradiation-induced and spontaneous carotid atherosclerosis. © 2002 Elsevier Science Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/172811
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.723
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, SWKen_US
dc.contributor.authorTing, ACWen_US
dc.contributor.authorWu, LLHen_US
dc.date.accessioned2012-10-30T06:25:02Z-
dc.date.available2012-10-30T06:25:02Z-
dc.date.issued2002en_US
dc.identifier.citationEuropean Journal Of Vascular And Endovascular Surgery, 2002, v. 24 n. 6, p. 499-504en_US
dc.identifier.issn1078-5884en_US
dc.identifier.urihttp://hdl.handle.net/10722/172811-
dc.description.abstractObjectives: to investigate the effect of external irradiation on the morphology of atherosclerotic plaques and the intimal-medial thickness of the carotid artery. Methods: a group of 46 patients (16 symptomatic) who had received external irradiation to the head and neck area more than five years previously and developed carotid stenosis exceeding 50%, were evaluated by duplex ultrasound. The carotid artery lumen, intimal-medial complex, and the plaque echogenicity was determined using computer digital image processing methods, forty-six age and sex matched patients with similar degrees of non-radiation associated carotid stenosis were used as controls. Results: irradiated stenotic carotid arteries had a greater intimal-medial thickness (0.96 mm vs 0.80 mm, p = 0.008) and a narrower lumen (5.5 mm vs 6.6 mm, p < 0.002) than the controls. The carotid plaque characteristics (gray-scale median (GSM) and heterogeneity) of the irradiated and control groups did not differ significantly. Symptomatic patients who had received external radiotherapy to the head and neck have a more echolucent plaque (mean GSM of 98) than their asymptomatic counterparts (mean GSM 114, p = 0.03). Intimal-medial thickness and carotid lumen was not related to the occurrence of symptoms. Conclusions: external irradiation to the head and neck area leads to significantly increased thickness of the carotid wall and a corresponding narrowing of the lumen. There seems to be no difference in the plaque characteristics between irradiation-induced and spontaneous carotid atherosclerosis. © 2002 Elsevier Science Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejvsen_US
dc.relation.ispartofEuropean Journal of Vascular and Endovascular Surgeryen_US
dc.rightsWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejvs-
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshArteriosclerosis - Etiology - Ultrasonographyen_US
dc.subject.meshCarotid Stenosis - Etiology - Ultrasonographyen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHead And Neck Neoplasms - Radiotherapyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRadiotherapy - Adverse Effectsen_US
dc.subject.meshSeverity Of Illness Indexen_US
dc.subject.meshTunica Intima - Radiation Effects - Ultrasonographyen_US
dc.subject.meshUltrasonography, Doppler, Coloren_US
dc.titleUltrasonic analysis of plaque characteristics and intimal-medial thickness in radiation-induced atherosclerotic carotid arteriesen_US
dc.typeArticleen_US
dc.identifier.emailCheng, SWK: wkcheng@hkucc.hku.hken_US
dc.identifier.authorityCheng, SWK=rp00374en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1053/ejvs.2002.1752en_US
dc.identifier.pmid12443744-
dc.identifier.scopuseid_2-s2.0-0036885033en_US
dc.identifier.hkuros81783-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036885033&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume24en_US
dc.identifier.issue6en_US
dc.identifier.spage499en_US
dc.identifier.epage504en_US
dc.identifier.isiWOS:000179554600005-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridCheng, SWK=7404684779en_US
dc.identifier.scopusauthoridTing, ACW=7102858552en_US
dc.identifier.scopusauthoridWu, LLH=7404903103en_US

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