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Article: Genetic analysis of the CYP2D6 locus in a Hong Kong Chinese population

TitleGenetic analysis of the CYP2D6 locus in a Hong Kong Chinese population
Authors
Issue Date2000
PublisherAmerican Association for Clinical Chemistry, Inc. The Journal's web site is located at http://www.clinchem.org
Citation
Clinical Chemistry, 2000, v. 46 n. 1, p. 18-23 How to Cite?
AbstractBackground: The cytochrome P450 CYP2D6 enzyme debrisoquine 4-hydroxylase metabolizes many different classes of commonly used drugs, such as tricyclic antidepressants and neuroleptics. Genetic polymorphism of the CYP2D6 gene is responsible for pronounced interindividual and interracial differences in the metabolism of these drugs. The CYP2D6*10 allele and its variants are the most frequent alleles found in Orientals, and they are responsible for diminished debrisoquine 4-hydroxylase activity because of the presence of a C 188→T mutation in exon 1. Methods: One hundred nineteen Hong Kong Chinese subjects were genotyped by means of allele-specific PCR, PCR, and restriction enzyme analysis for 10 CYP2D6 alleles (CYP2D6*1, *2, *4D, *5, *8/*14, *10A, *10B, *15, *16, and J9). Results: CYP2D6*10B was the most prevalent allele, and CYP2D6*10/CYP2D6*10 was the most frequent genotype, representing 46.22% of the population. Conclusions: There was no significant difference in the prevalence of the alleles analyzed between our study and the Chinese populations genotyped previously. This is the largest study in terms of the number of CYP2D6 alleles analyzed in an Oriental population and the first one conducted in a Hong Kong Chinese population. (C) 2000 American Association for Clinical Chemistry.
Persistent Identifierhttp://hdl.handle.net/10722/172775
ISSN
2015 Impact Factor: 7.457
2015 SCImago Journal Rankings: 2.472
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGarciaBarceló, Men_US
dc.contributor.authorChow, LYen_US
dc.contributor.authorChiu, HFKen_US
dc.contributor.authorWing, YKen_US
dc.contributor.authorLee, DTSen_US
dc.contributor.authorLam, KLen_US
dc.contributor.authorWaye, MMYen_US
dc.date.accessioned2012-10-30T06:24:51Z-
dc.date.available2012-10-30T06:24:51Z-
dc.date.issued2000en_US
dc.identifier.citationClinical Chemistry, 2000, v. 46 n. 1, p. 18-23en_US
dc.identifier.issn0009-9147en_US
dc.identifier.urihttp://hdl.handle.net/10722/172775-
dc.description.abstractBackground: The cytochrome P450 CYP2D6 enzyme debrisoquine 4-hydroxylase metabolizes many different classes of commonly used drugs, such as tricyclic antidepressants and neuroleptics. Genetic polymorphism of the CYP2D6 gene is responsible for pronounced interindividual and interracial differences in the metabolism of these drugs. The CYP2D6*10 allele and its variants are the most frequent alleles found in Orientals, and they are responsible for diminished debrisoquine 4-hydroxylase activity because of the presence of a C 188→T mutation in exon 1. Methods: One hundred nineteen Hong Kong Chinese subjects were genotyped by means of allele-specific PCR, PCR, and restriction enzyme analysis for 10 CYP2D6 alleles (CYP2D6*1, *2, *4D, *5, *8/*14, *10A, *10B, *15, *16, and J9). Results: CYP2D6*10B was the most prevalent allele, and CYP2D6*10/CYP2D6*10 was the most frequent genotype, representing 46.22% of the population. Conclusions: There was no significant difference in the prevalence of the alleles analyzed between our study and the Chinese populations genotyped previously. This is the largest study in terms of the number of CYP2D6 alleles analyzed in an Oriental population and the first one conducted in a Hong Kong Chinese population. (C) 2000 American Association for Clinical Chemistry.en_US
dc.languageengen_US
dc.publisherAmerican Association for Clinical Chemistry, Inc. The Journal's web site is located at http://www.clinchem.orgen_US
dc.relation.ispartofClinical Chemistryen_US
dc.subject.meshAllelesen_US
dc.subject.meshCytochrome P-450 Cyp2d6 - Geneticsen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.titleGenetic analysis of the CYP2D6 locus in a Hong Kong Chinese populationen_US
dc.typeArticleen_US
dc.identifier.emailGarciaBarceló, M: mmgarcia@hkucc.hku.hken_US
dc.identifier.authorityGarciaBarceló, M=rp00445en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10620567-
dc.identifier.scopuseid_2-s2.0-0033965373en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033965373&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume46en_US
dc.identifier.issue1en_US
dc.identifier.spage18en_US
dc.identifier.epage23en_US
dc.identifier.isiWOS:000084793100003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGarciaBarceló, M=6701767303en_US
dc.identifier.scopusauthoridChow, LY=7202533095en_US
dc.identifier.scopusauthoridChiu, HFK=7401986628en_US
dc.identifier.scopusauthoridWing, YK=21535991900en_US
dc.identifier.scopusauthoridLee, DTS=37047044600en_US
dc.identifier.scopusauthoridLam, KL=7403656836en_US
dc.identifier.scopusauthoridWaye, MMY=7006687733en_US

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