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Article: Chromosomal mapping, tissue distribution and cDNA sequence of Four-and-a-half LIM domain protein 1 (FHL1)

TitleChromosomal mapping, tissue distribution and cDNA sequence of Four-and-a-half LIM domain protein 1 (FHL1)
Authors
Issue Date1998
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/gene
Citation
Gene, 1998, v. 216 n. 1, p. 163-170 How to Cite?
AbstractWe have isolated and sequenced a human heart cDNA clone encoding a novel LIM-only protein. This full-length cDNA clone has a predicted open reading frame (ORF) encoding 280 amino acids. The ORF of this cDNA codes for a LIM-only protein that possesses four repeats of LIM domain and an extra zinc finger and this putative protein is named four-and-a-half LIM domain protein 1 (FHL1). FHL1 is unique when compared with other LIM-only proteins because it possesses an odd number of zinc fingers. When the FHL1 cDNA probe was used to hybridize with poly-(A) RNA of various human tissues, a very strong signal was detected in skeletal muscle, a moderate one in the heart; only weak signals were associated with the placenta, ovary, prostate, testis, small intestine, colon and spleen, and virtually no signal could be detected in brain, lung, liver, kidney, pancreas, thymus and peripheral blood leukocytes. The FHL1 gene was located to human chromosome at Xq27.2 by somatic cell hybrid mapping, fluorescent in situ hybridization (FISH) and radiation hybrid mapping.
Persistent Identifierhttp://hdl.handle.net/10722/172752
ISSN
2015 Impact Factor: 2.319
2015 SCImago Journal Rankings: 1.043
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, SMYen_US
dc.contributor.authorTsui, SKWen_US
dc.contributor.authorChan, KKen_US
dc.contributor.authorGarciaBarcelo, Men_US
dc.contributor.authorWaye, MMYen_US
dc.contributor.authorFung, KPen_US
dc.contributor.authorLiew, CCen_US
dc.contributor.authorLee, CYen_US
dc.date.accessioned2012-10-30T06:24:42Z-
dc.date.available2012-10-30T06:24:42Z-
dc.date.issued1998en_US
dc.identifier.citationGene, 1998, v. 216 n. 1, p. 163-170en_US
dc.identifier.issn0378-1119en_US
dc.identifier.urihttp://hdl.handle.net/10722/172752-
dc.description.abstractWe have isolated and sequenced a human heart cDNA clone encoding a novel LIM-only protein. This full-length cDNA clone has a predicted open reading frame (ORF) encoding 280 amino acids. The ORF of this cDNA codes for a LIM-only protein that possesses four repeats of LIM domain and an extra zinc finger and this putative protein is named four-and-a-half LIM domain protein 1 (FHL1). FHL1 is unique when compared with other LIM-only proteins because it possesses an odd number of zinc fingers. When the FHL1 cDNA probe was used to hybridize with poly-(A) RNA of various human tissues, a very strong signal was detected in skeletal muscle, a moderate one in the heart; only weak signals were associated with the placenta, ovary, prostate, testis, small intestine, colon and spleen, and virtually no signal could be detected in brain, lung, liver, kidney, pancreas, thymus and peripheral blood leukocytes. The FHL1 gene was located to human chromosome at Xq27.2 by somatic cell hybrid mapping, fluorescent in situ hybridization (FISH) and radiation hybrid mapping.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/geneen_US
dc.relation.ispartofGeneen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshDna, Complementary - Chemistry - Geneticsen_US
dc.subject.meshHomeodomain Proteins - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshRna, Messenger - Genetics - Metabolismen_US
dc.subject.meshSequence Analysis, Dnaen_US
dc.subject.meshSequence Homology, Amino Aciden_US
dc.subject.meshSequence Homology, Nucleic Aciden_US
dc.subject.meshTissue Distributionen_US
dc.subject.meshX Chromosome - Geneticsen_US
dc.titleChromosomal mapping, tissue distribution and cDNA sequence of Four-and-a-half LIM domain protein 1 (FHL1)en_US
dc.typeArticleen_US
dc.identifier.emailGarciaBarcelo, M: mmgarcia@hkucc.hku.hken_US
dc.identifier.authorityGarciaBarcelo, M=rp00445en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0378-1119(98)00302-3en_US
dc.identifier.pmid9714789-
dc.identifier.scopuseid_2-s2.0-0032541324en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032541324&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume216en_US
dc.identifier.issue1en_US
dc.identifier.spage163en_US
dc.identifier.epage170en_US
dc.identifier.isiWOS:000075606600019-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLee, SMY=35233892600en_US
dc.identifier.scopusauthoridTsui, SKW=7004961364en_US
dc.identifier.scopusauthoridChan, KK=7406034649en_US
dc.identifier.scopusauthoridGarciaBarcelo, M=6701767303en_US
dc.identifier.scopusauthoridWaye, MMY=7006687733en_US
dc.identifier.scopusauthoridFung, KP=7202934739en_US
dc.identifier.scopusauthoridLiew, CC=35806765000en_US
dc.identifier.scopusauthoridLee, CY=7410142857en_US

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