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- Publisher Website: 10.1111/j.1445-2197.1994.tb04534.x
- Scopus: eid_2-s2.0-0028075914
- PMID: 7945083
- WOS: WOS:A1994PP65900007
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Article: Evaluation of indocyanine green retention and aminopyrine breath tests in patients with malignant biliary obstruction
Title | Evaluation of indocyanine green retention and aminopyrine breath tests in patients with malignant biliary obstruction |
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Authors | |
Keywords | Aminopyrine breath test Indocyanine green retention Malignancy Obstructive jaundice |
Issue Date | 1994 |
Publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ANS |
Citation | Australian And New Zealand Journal Of Surgery, 1994, v. 64 n. 11, p. 759-762 How to Cite? |
Abstract | Impaired hepatic function is a major contributory factor to the high incidence of postoperative morbidity and mortality in patients with malignant biliary obstruction. Dynamic hepatic function tests such as indocyanine green (ICG) retention and aminopyrine breath tests were evaluated in such patients to define whether they were clinically useful for prediction of postoperative morbidity and mortality. Forty-four patients with malignant biliary obstruction undergoing surgery for relief of obstructive jaundice were recruited into the study. Indocyanine green retention and aminopyrine breath tests were carried out in all patients pre-operatively and repeated in 36 patients postoperatively. The ICG retention was abnormal in all patients before surgery and there was significant improvement 2 weeks after surgery (32.8 ± 2.5% vs 18.3 ± 2.8%, P = 0.001). The change in ICG retention levels correlated with the serum bilirubin levels but the pre-operative ICG retention value could not predict postoperative morbidity and mortality. The aminopyrine breath test was abnormal in all but one patient. It correlated with pre-operative prothrombin time of the patients before surgery but it did not improve significantly after surgery and was not predictive of postoperative outcome. It is concluded that both ICG retention and aminopyrine breath tests have limited clinical value in the pre-operative evaluation of patients with malignant biliary obstruction. |
Persistent Identifier | http://hdl.handle.net/10722/172706 |
ISSN | 2020 SCImago Journal Rankings: 0.111 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Fan, ST | en_HK |
dc.contributor.author | Wang, QS | en_HK |
dc.contributor.author | Lo, CM | en_HK |
dc.contributor.author | Yu, KWT | en_HK |
dc.contributor.author | Lai, ECS | en_HK |
dc.contributor.author | Wong, J | en_HK |
dc.date.accessioned | 2012-10-30T06:24:24Z | - |
dc.date.available | 2012-10-30T06:24:24Z | - |
dc.date.issued | 1994 | en_HK |
dc.identifier.citation | Australian And New Zealand Journal Of Surgery, 1994, v. 64 n. 11, p. 759-762 | en_HK |
dc.identifier.issn | 0004-8682 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/172706 | - |
dc.description.abstract | Impaired hepatic function is a major contributory factor to the high incidence of postoperative morbidity and mortality in patients with malignant biliary obstruction. Dynamic hepatic function tests such as indocyanine green (ICG) retention and aminopyrine breath tests were evaluated in such patients to define whether they were clinically useful for prediction of postoperative morbidity and mortality. Forty-four patients with malignant biliary obstruction undergoing surgery for relief of obstructive jaundice were recruited into the study. Indocyanine green retention and aminopyrine breath tests were carried out in all patients pre-operatively and repeated in 36 patients postoperatively. The ICG retention was abnormal in all patients before surgery and there was significant improvement 2 weeks after surgery (32.8 ± 2.5% vs 18.3 ± 2.8%, P = 0.001). The change in ICG retention levels correlated with the serum bilirubin levels but the pre-operative ICG retention value could not predict postoperative morbidity and mortality. The aminopyrine breath test was abnormal in all but one patient. It correlated with pre-operative prothrombin time of the patients before surgery but it did not improve significantly after surgery and was not predictive of postoperative outcome. It is concluded that both ICG retention and aminopyrine breath tests have limited clinical value in the pre-operative evaluation of patients with malignant biliary obstruction. | en_HK |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ANS | en_HK |
dc.relation.ispartof | Australian and New Zealand Journal of Surgery | en_HK |
dc.subject | Aminopyrine breath test | en_HK |
dc.subject | Indocyanine green retention | en_HK |
dc.subject | Malignancy | en_HK |
dc.subject | Obstructive jaundice | en_HK |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Aged, 80 And Over | en_US |
dc.subject.mesh | Aminopyrine - Diagnostic Use | en_US |
dc.subject.mesh | Breath Tests | en_US |
dc.subject.mesh | Cholestasis - Physiopathology - Surgery | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Indocyanine Green - Diagnostic Use | en_US |
dc.subject.mesh | Liver Function Tests | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Postoperative Period | en_US |
dc.subject.mesh | Treatment Outcome | en_US |
dc.title | Evaluation of indocyanine green retention and aminopyrine breath tests in patients with malignant biliary obstruction | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Fan, ST: stfan@hku.hk | en_HK |
dc.identifier.email | Lo, CM: chungmlo@hkucc.hku.hk | en_HK |
dc.identifier.email | Wong, J: jwong@hkucc.hku.hk | en_HK |
dc.identifier.authority | Fan, ST=rp00355 | en_HK |
dc.identifier.authority | Lo, CM=rp00412 | en_HK |
dc.identifier.authority | Wong, J=rp00322 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1445-2197.1994.tb04534.x | - |
dc.identifier.pmid | 7945083 | - |
dc.identifier.scopus | eid_2-s2.0-0028075914 | en_HK |
dc.identifier.hkuros | 3661 | - |
dc.identifier.volume | 64 | en_HK |
dc.identifier.issue | 11 | en_HK |
dc.identifier.spage | 759 | en_HK |
dc.identifier.epage | 762 | en_HK |
dc.identifier.isi | WOS:A1994PP65900007 | - |
dc.publisher.place | Australia | en_HK |
dc.identifier.scopusauthorid | Fan, ST=7402678224 | en_HK |
dc.identifier.scopusauthorid | Wang, QS=37666778700 | en_HK |
dc.identifier.scopusauthorid | Lo, CM=7401771672 | en_HK |
dc.identifier.scopusauthorid | Yu, KWT=7403385717 | en_HK |
dc.identifier.scopusauthorid | Lai, ECS=36932159600 | en_HK |
dc.identifier.scopusauthorid | Wong, J=8049324500 | en_HK |
dc.identifier.issnl | 0004-8682 | - |