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Article: Evaluation of indocyanine green retention and aminopyrine breath tests in patients with malignant biliary obstruction

TitleEvaluation of indocyanine green retention and aminopyrine breath tests in patients with malignant biliary obstruction
Authors
KeywordsAminopyrine breath test
Indocyanine green retention
Malignancy
Obstructive jaundice
Issue Date1994
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ANS
Citation
Australian And New Zealand Journal Of Surgery, 1994, v. 64 n. 11, p. 759-762 How to Cite?
AbstractImpaired hepatic function is a major contributory factor to the high incidence of postoperative morbidity and mortality in patients with malignant biliary obstruction. Dynamic hepatic function tests such as indocyanine green (ICG) retention and aminopyrine breath tests were evaluated in such patients to define whether they were clinically useful for prediction of postoperative morbidity and mortality. Forty-four patients with malignant biliary obstruction undergoing surgery for relief of obstructive jaundice were recruited into the study. Indocyanine green retention and aminopyrine breath tests were carried out in all patients pre-operatively and repeated in 36 patients postoperatively. The ICG retention was abnormal in all patients before surgery and there was significant improvement 2 weeks after surgery (32.8 ± 2.5% vs 18.3 ± 2.8%, P = 0.001). The change in ICG retention levels correlated with the serum bilirubin levels but the pre-operative ICG retention value could not predict postoperative morbidity and mortality. The aminopyrine breath test was abnormal in all but one patient. It correlated with pre-operative prothrombin time of the patients before surgery but it did not improve significantly after surgery and was not predictive of postoperative outcome. It is concluded that both ICG retention and aminopyrine breath tests have limited clinical value in the pre-operative evaluation of patients with malignant biliary obstruction.
Persistent Identifierhttp://hdl.handle.net/10722/172706
ISSN
2003 Impact Factor: 0.874
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFan, STen_HK
dc.contributor.authorWang, QSen_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorYu, KWTen_HK
dc.contributor.authorLai, ECSen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2012-10-30T06:24:24Z-
dc.date.available2012-10-30T06:24:24Z-
dc.date.issued1994en_HK
dc.identifier.citationAustralian And New Zealand Journal Of Surgery, 1994, v. 64 n. 11, p. 759-762en_HK
dc.identifier.issn0004-8682en_HK
dc.identifier.urihttp://hdl.handle.net/10722/172706-
dc.description.abstractImpaired hepatic function is a major contributory factor to the high incidence of postoperative morbidity and mortality in patients with malignant biliary obstruction. Dynamic hepatic function tests such as indocyanine green (ICG) retention and aminopyrine breath tests were evaluated in such patients to define whether they were clinically useful for prediction of postoperative morbidity and mortality. Forty-four patients with malignant biliary obstruction undergoing surgery for relief of obstructive jaundice were recruited into the study. Indocyanine green retention and aminopyrine breath tests were carried out in all patients pre-operatively and repeated in 36 patients postoperatively. The ICG retention was abnormal in all patients before surgery and there was significant improvement 2 weeks after surgery (32.8 ± 2.5% vs 18.3 ± 2.8%, P = 0.001). The change in ICG retention levels correlated with the serum bilirubin levels but the pre-operative ICG retention value could not predict postoperative morbidity and mortality. The aminopyrine breath test was abnormal in all but one patient. It correlated with pre-operative prothrombin time of the patients before surgery but it did not improve significantly after surgery and was not predictive of postoperative outcome. It is concluded that both ICG retention and aminopyrine breath tests have limited clinical value in the pre-operative evaluation of patients with malignant biliary obstruction.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ANSen_HK
dc.relation.ispartofAustralian and New Zealand Journal of Surgeryen_HK
dc.subjectAminopyrine breath testen_HK
dc.subjectIndocyanine green retentionen_HK
dc.subjectMalignancyen_HK
dc.subjectObstructive jaundiceen_HK
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAminopyrine - Diagnostic Useen_US
dc.subject.meshBreath Testsen_US
dc.subject.meshCholestasis - Physiopathology - Surgeryen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIndocyanine Green - Diagnostic Useen_US
dc.subject.meshLiver Function Testsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPostoperative Perioden_US
dc.subject.meshTreatment Outcomeen_US
dc.titleEvaluation of indocyanine green retention and aminopyrine breath tests in patients with malignant biliary obstructionen_HK
dc.typeArticleen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1445-2197.1994.tb04534.x-
dc.identifier.pmid7945083-
dc.identifier.scopuseid_2-s2.0-0028075914en_HK
dc.identifier.hkuros3661-
dc.identifier.volume64en_HK
dc.identifier.issue11en_HK
dc.identifier.spage759en_HK
dc.identifier.epage762en_HK
dc.identifier.isiWOS:A1994PP65900007-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridWang, QS=37666778700en_HK
dc.identifier.scopusauthoridLo, CM=7401771672en_HK
dc.identifier.scopusauthoridYu, KWT=7403385717en_HK
dc.identifier.scopusauthoridLai, ECS=36932159600en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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