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Article: Transpalatal insertion of radioactive gold grain for the treatment of persistent and recurrent nasopharyngeal carcinoma

TitleTranspalatal insertion of radioactive gold grain for the treatment of persistent and recurrent nasopharyngeal carcinoma
Authors
Issue Date1993
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobp
Citation
International Journal of Radiation Oncology - Biology - Physics, 1993, v. 25 n. 3, p. 505-512 How to Cite?
AbstractPurpose: To evaluate the efficacy of radioactive gold grain implant via the split palate approach in the control of locally recurrent or persistent nasopharyngeal carcinoma. Methods and Material: Forty-three patients, 10 for persistent NPC, 28 for first relapse in the nasopharynx, and five for second relapse in the nasopharynx, were treated. The diameter of the tumors at the time of gold grain implant ranged from 0.5 to 5 cm, the number of gold grains inserted varied from 4 to 14, the median number was seven. Results: There was no significant difference in the control of the primary tumor for persistent disease (80% at 5 years), first relapse (61% at 5 years) and second relapse (80% at 3 years), p = 0.8845. The difference in survival between the three subgroups of patients, however, was highly significant (p = 0.0040). Thirty patients had CT evaluation before gold grain implant and the tumor was found confined to the nasopharynx in 21, in the remaining nine patients erosion of the sphenoid sinus or other parts of the base of skull was noted. The difference in the control between those patients with tumors confined to the nasopharynx and those patients with extranasopharyngeal extension of tumor almost reached statistical significance (81% and 44% respectively at 5 years, p = 0.0554). For the six patients who developed local recurrence after gold grain implant and were evaluable for the pattern of failure, the recurrent tumors were considered originating from another region of the nasopharynx in four, and infield failure in the other two cases. Conclusion: Radioactive gold grain implant as salvage treatment provides satisfactory control of persistent and recurrent nasopharyngeal carcinoma. The local control was better when the tumor was localized to the nasopharynx, thus underlines the importance of close follow-up for early recognition of relapse and persistent tumor. However, such patients still suffered from high incidence of regional and distant failure, the pathophysiology and management of which require further investigation.
Persistent Identifierhttp://hdl.handle.net/10722/172693
ISSN
2015 Impact Factor: 4.495
2015 SCImago Journal Rankings: 2.274
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChoy, Den_US
dc.contributor.authorSham, JSTen_US
dc.contributor.authorWei, WIen_US
dc.contributor.authorHo, CMen_US
dc.contributor.authorWu, PMen_US
dc.date.accessioned2012-10-30T06:24:20Z-
dc.date.available2012-10-30T06:24:20Z-
dc.date.issued1993en_US
dc.identifier.citationInternational Journal of Radiation Oncology - Biology - Physics, 1993, v. 25 n. 3, p. 505-512en_US
dc.identifier.issn0360-3016en_US
dc.identifier.urihttp://hdl.handle.net/10722/172693-
dc.description.abstractPurpose: To evaluate the efficacy of radioactive gold grain implant via the split palate approach in the control of locally recurrent or persistent nasopharyngeal carcinoma. Methods and Material: Forty-three patients, 10 for persistent NPC, 28 for first relapse in the nasopharynx, and five for second relapse in the nasopharynx, were treated. The diameter of the tumors at the time of gold grain implant ranged from 0.5 to 5 cm, the number of gold grains inserted varied from 4 to 14, the median number was seven. Results: There was no significant difference in the control of the primary tumor for persistent disease (80% at 5 years), first relapse (61% at 5 years) and second relapse (80% at 3 years), p = 0.8845. The difference in survival between the three subgroups of patients, however, was highly significant (p = 0.0040). Thirty patients had CT evaluation before gold grain implant and the tumor was found confined to the nasopharynx in 21, in the remaining nine patients erosion of the sphenoid sinus or other parts of the base of skull was noted. The difference in the control between those patients with tumors confined to the nasopharynx and those patients with extranasopharyngeal extension of tumor almost reached statistical significance (81% and 44% respectively at 5 years, p = 0.0554). For the six patients who developed local recurrence after gold grain implant and were evaluable for the pattern of failure, the recurrent tumors were considered originating from another region of the nasopharynx in four, and infield failure in the other two cases. Conclusion: Radioactive gold grain implant as salvage treatment provides satisfactory control of persistent and recurrent nasopharyngeal carcinoma. The local control was better when the tumor was localized to the nasopharynx, thus underlines the importance of close follow-up for early recognition of relapse and persistent tumor. However, such patients still suffered from high incidence of regional and distant failure, the pathophysiology and management of which require further investigation.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ijrobpen_US
dc.relation.ispartofInternational Journal of Radiation Oncology - Biology - Physicsen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBrachytherapyen_US
dc.subject.meshEvaluation Studies As Topicen_US
dc.subject.meshFemaleen_US
dc.subject.meshGold Colloid, Radioactive - Administration & Dosage - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNasopharyngeal Neoplasms - Radiotherapyen_US
dc.subject.meshNeoplasm Recurrence, Local - Radiotherapyen_US
dc.subject.meshPalateen_US
dc.titleTranspalatal insertion of radioactive gold grain for the treatment of persistent and recurrent nasopharyngeal carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailWei, WI: hrmswwi@hku.hken_US
dc.identifier.authorityWei, WI=rp00323en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0360-3016(93)90073-5-
dc.identifier.pmid8382202-
dc.identifier.scopuseid_2-s2.0-0027450527en_US
dc.identifier.volume25en_US
dc.identifier.issue3en_US
dc.identifier.spage505en_US
dc.identifier.epage512en_US
dc.identifier.isiWOS:A1993KP47700016-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChoy, D=7102939127en_US
dc.identifier.scopusauthoridSham, JST=7101655565en_US
dc.identifier.scopusauthoridWei, WI=7403321552en_US
dc.identifier.scopusauthoridHo, CM=7404652540en_US
dc.identifier.scopusauthoridWu, PM=8663653900en_US

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