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Article: Metabolic clearance of a fat emulsion containing medium-chain triglycerides in cirrhotic patients

TitleMetabolic clearance of a fat emulsion containing medium-chain triglycerides in cirrhotic patients
Authors
Issue Date1992
PublisherSage Publications, Inc.. The Journal's web site is located at http://pen.sagepub.com
Citation
Journal Of Parenteral And Enteral Nutrition, 1992, v. 16 n. 3, p. 279-283 How to Cite?
AbstractMedium-chain triglycerides (MCTs) may be advantageous in cirrhotic patients, but data on the clearing capacity are lacking. Intravenous fat tolerance test (IVFTT) was performed on 28 cirrhotic patients (Child's A, n = 9; Child's B, n = 13; Child's C, n = 6) to determine the clearance rate of Lipofundin MCT 20%, which contains a physical mixture of MCT and long-chain triglycerides (LCT). The mean fractional elimination rate (k2) of MCT/LCT physical blend in the cirrhotic patients (7.72%/min) was comparable with that of the healthy control subjects (n = 9, k2 = 5.43%/min). Significantly higher serum free fatty acid (FFA) levels were found in the cirrhotic patients during IVFTT. The difference could be accounted for by their higher basal levels. In all patients, serum FFA concentrations returned to basal value at the end of 1 hour. Prompt appearance of glycerol and β- hydroxybutyrate was seen during IVFTT, indicating that hydrolysis of triglycerides and release of ketone bodies from the liver were rapid. It was concluded that the ability to eliminate MCT/LCT physical blend was not impaired in the cirrhotic patients.
Persistent Identifierhttp://hdl.handle.net/10722/172667
ISSN
2015 Impact Factor: 3.517
2015 SCImago Journal Rankings: 1.149
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFan, STen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2012-10-30T06:24:08Z-
dc.date.available2012-10-30T06:24:08Z-
dc.date.issued1992en_HK
dc.identifier.citationJournal Of Parenteral And Enteral Nutrition, 1992, v. 16 n. 3, p. 279-283en_HK
dc.identifier.issn0148-6071en_HK
dc.identifier.urihttp://hdl.handle.net/10722/172667-
dc.description.abstractMedium-chain triglycerides (MCTs) may be advantageous in cirrhotic patients, but data on the clearing capacity are lacking. Intravenous fat tolerance test (IVFTT) was performed on 28 cirrhotic patients (Child's A, n = 9; Child's B, n = 13; Child's C, n = 6) to determine the clearance rate of Lipofundin MCT 20%, which contains a physical mixture of MCT and long-chain triglycerides (LCT). The mean fractional elimination rate (k2) of MCT/LCT physical blend in the cirrhotic patients (7.72%/min) was comparable with that of the healthy control subjects (n = 9, k2 = 5.43%/min). Significantly higher serum free fatty acid (FFA) levels were found in the cirrhotic patients during IVFTT. The difference could be accounted for by their higher basal levels. In all patients, serum FFA concentrations returned to basal value at the end of 1 hour. Prompt appearance of glycerol and β- hydroxybutyrate was seen during IVFTT, indicating that hydrolysis of triglycerides and release of ketone bodies from the liver were rapid. It was concluded that the ability to eliminate MCT/LCT physical blend was not impaired in the cirrhotic patients.en_HK
dc.languageengen_US
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://pen.sagepub.comen_HK
dc.relation.ispartofJournal of Parenteral and Enteral Nutritionen_HK
dc.subject.mesh3-Hydroxybutyric Aciden_US
dc.subject.meshFat Emulsions, Intravenous - Pharmacokineticsen_US
dc.subject.meshFatty Acids, Nonesterified - Blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshGlycerol - Blooden_US
dc.subject.meshHumansen_US
dc.subject.meshHydroxybutyrates - Blooden_US
dc.subject.meshLiver Cirrhosis - Metabolism - Therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshParenteral Nutritionen_US
dc.subject.meshTriglycerides - Pharmacokineticsen_US
dc.titleMetabolic clearance of a fat emulsion containing medium-chain triglycerides in cirrhotic patientsen_HK
dc.typeArticleen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1177/0148607192016003279-
dc.identifier.pmid1501361-
dc.identifier.scopuseid_2-s2.0-0026558026en_HK
dc.identifier.volume16en_HK
dc.identifier.issue3en_HK
dc.identifier.spage279en_HK
dc.identifier.epage283en_HK
dc.identifier.isiWOS:A1992HT97900013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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