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Article: Nasopharyngeal carcinoma and lymphoinfiltration

TitleNasopharyngeal carcinoma and lymphoinfiltration
Authors
Issue Date1991
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/OCL
Citation
Oncology, 1991, v. 48 n. 4, p. 290-296 How to Cite?
AbstractOriginally referred to as 'lymphoepithelioma', undifferentiated and poorly differentiated nasopharyngeal carcinoma (NPC) tissues showed intense lymphoinfiltration. In a study of cryosections from 15 NPC tissues, we found that infiltrating lymphoid elements were comprised predominantly of lymphocytes, but plasma cells, follicular dendritic cells, and eosinophils were also commonly seen. Subpopulations of lymphocytes having the same phenotypes tend to aggregate, forming clusters or secondary follicles in stromatous tissues. The tumor areas were mainly infiltrated by T cells. Tumor cells and/or apparently normal epithelium in the paratumorous areas frequently expressed CD21, CD23, CD40 and a B lymphocytes carcinoma cross-reacting antigen (BLCa), all of which are involved in B cell activation and proliferation. CD21 and BLCa were strongly expressed near the surface of both squamous and columnar epithelium by those epithelial cells which are at advanced stage of differentiation, while CD40 was expressed by epithelial cells at earlier stages of differentiation located at or near the basement membrane. CD23 was mainly expressed by columnar cells and basal cells underlying squamous epithelium, but not, or weakly so, by flattened squamous cells or reserve cells underlying columnar epithelium. The large majority of tumor cells expressed CD40 and BLCa. A substantial proportion of them also expressed CD23, but the tumor cells were not reactive for CD21. Despite eosinophilic infiltration, IL-6 was not detected in tumor tissues. IL-1 was, however, detected in abundance in the cytoplasm of follicular dendritic-like cells and in the intercellular spaces in tumor areas and surrounding stromatous tissues. The immunobiology of NPC is discussed in the light of these observations.
Persistent Identifierhttp://hdl.handle.net/10722/172642
ISSN
2015 Impact Factor: 2.152
2015 SCImago Journal Rankings: 0.920
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZong, YSen_US
dc.contributor.authorLin, Hen_US
dc.contributor.authorChoy, DTKen_US
dc.contributor.authorSham, JSTen_US
dc.contributor.authorWei, Wen_US
dc.contributor.authorChan, KHen_US
dc.contributor.authorNg, MHen_US
dc.date.accessioned2012-10-30T06:23:59Z-
dc.date.available2012-10-30T06:23:59Z-
dc.date.issued1991en_US
dc.identifier.citationOncology, 1991, v. 48 n. 4, p. 290-296en_US
dc.identifier.issn0030-2414en_US
dc.identifier.urihttp://hdl.handle.net/10722/172642-
dc.description.abstractOriginally referred to as 'lymphoepithelioma', undifferentiated and poorly differentiated nasopharyngeal carcinoma (NPC) tissues showed intense lymphoinfiltration. In a study of cryosections from 15 NPC tissues, we found that infiltrating lymphoid elements were comprised predominantly of lymphocytes, but plasma cells, follicular dendritic cells, and eosinophils were also commonly seen. Subpopulations of lymphocytes having the same phenotypes tend to aggregate, forming clusters or secondary follicles in stromatous tissues. The tumor areas were mainly infiltrated by T cells. Tumor cells and/or apparently normal epithelium in the paratumorous areas frequently expressed CD21, CD23, CD40 and a B lymphocytes carcinoma cross-reacting antigen (BLCa), all of which are involved in B cell activation and proliferation. CD21 and BLCa were strongly expressed near the surface of both squamous and columnar epithelium by those epithelial cells which are at advanced stage of differentiation, while CD40 was expressed by epithelial cells at earlier stages of differentiation located at or near the basement membrane. CD23 was mainly expressed by columnar cells and basal cells underlying squamous epithelium, but not, or weakly so, by flattened squamous cells or reserve cells underlying columnar epithelium. The large majority of tumor cells expressed CD40 and BLCa. A substantial proportion of them also expressed CD23, but the tumor cells were not reactive for CD21. Despite eosinophilic infiltration, IL-6 was not detected in tumor tissues. IL-1 was, however, detected in abundance in the cytoplasm of follicular dendritic-like cells and in the intercellular spaces in tumor areas and surrounding stromatous tissues. The immunobiology of NPC is discussed in the light of these observations.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/OCLen_US
dc.relation.ispartofOncologyen_US
dc.subject.meshAntibodies, Monoclonal - Diagnostic Useen_US
dc.subject.meshAntigens, Cd - Analysisen_US
dc.subject.meshB-Lymphocytes - Immunology - Pathologyen_US
dc.subject.meshBiopsyen_US
dc.subject.meshEosinophils - Pathologyen_US
dc.subject.meshEpithelium - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin G - Classificationen_US
dc.subject.meshNasopharyngeal Neoplasms - Immunology - Pathologyen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshT-Lymphocytes - Immunology - Pathologyen_US
dc.titleNasopharyngeal carcinoma and lymphoinfiltrationen_US
dc.typeArticleen_US
dc.identifier.emailWei, W: hrmswwi@hku.hken_US
dc.identifier.authorityWei, W=rp00323en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000226945-
dc.identifier.pmid1891170-
dc.identifier.scopuseid_2-s2.0-0025816015en_US
dc.identifier.volume48en_US
dc.identifier.issue4en_US
dc.identifier.spage290en_US
dc.identifier.epage296en_US
dc.identifier.isiWOS:A1991GE18400006-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridZong, YS=7005203474en_US
dc.identifier.scopusauthoridLin, H=7405571292en_US
dc.identifier.scopusauthoridChoy, DTK=7102939127en_US
dc.identifier.scopusauthoridSham, JST=7101655565en_US
dc.identifier.scopusauthoridWei, W=7403321552en_US
dc.identifier.scopusauthoridChan, KH=35338760600en_US
dc.identifier.scopusauthoridNg, MH=7202076421en_US

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