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Article: Tumor clearance at resection margins in total laryngectomy. A clinicopathologic study

TitleTumor clearance at resection margins in total laryngectomy. A clinicopathologic study
Authors
Issue Date1988
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 1988, v. 61 n. 11, p. 2260-2272 How to Cite?
AbstractThe specimens from total laryngectomy performed in 70 patients were studied using the step-serial whole organ sectioning technique. Transverse histologic sections were taken and examined for minimum tumor clearance. The clinical status of patients for at least 4 years of observation was correlated with microscopic clearance of margins. The actual presence of tumor at the margins of resection was found in 21 (30%) of the specimens. The tumor was found to reach within 1 mm, 2 mm, and more than 2 mm from the margins in nine (13%), four (6%), and 36 (51%) specimens, respectively. The anterolateral margin was most commonly involved (19%), followed by the posterolateral (11%), postcricoid (7%), and upper (1.4%) margins. Local recurrence was found to be related to degree of clearance as 10 of 21 (48%) patients with no clearance and one of nine (11%) with 1 mm clearance had local failure. None of the patients with 2 mm clearance or more developed local recurrence. It is concluded that step-serial whole organ sectioning is an adequate method for thoroughly examining resection margins in laryngectomy specimens.
Persistent Identifierhttp://hdl.handle.net/10722/172588
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, KHen_US
dc.contributor.authorLau, WFen_US
dc.contributor.authorWei, WIen_US
dc.date.accessioned2012-10-30T06:23:34Z-
dc.date.available2012-10-30T06:23:34Z-
dc.date.issued1988en_US
dc.identifier.citationCancer, 1988, v. 61 n. 11, p. 2260-2272en_US
dc.identifier.issn0008-543Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/172588-
dc.description.abstractThe specimens from total laryngectomy performed in 70 patients were studied using the step-serial whole organ sectioning technique. Transverse histologic sections were taken and examined for minimum tumor clearance. The clinical status of patients for at least 4 years of observation was correlated with microscopic clearance of margins. The actual presence of tumor at the margins of resection was found in 21 (30%) of the specimens. The tumor was found to reach within 1 mm, 2 mm, and more than 2 mm from the margins in nine (13%), four (6%), and 36 (51%) specimens, respectively. The anterolateral margin was most commonly involved (19%), followed by the posterolateral (11%), postcricoid (7%), and upper (1.4%) margins. Local recurrence was found to be related to degree of clearance as 10 of 21 (48%) patients with no clearance and one of nine (11%) with 1 mm clearance had local failure. None of the patients with 2 mm clearance or more developed local recurrence. It is concluded that step-serial whole organ sectioning is an adequate method for thoroughly examining resection margins in laryngectomy specimens.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_US
dc.relation.ispartofCanceren_US
dc.subject.meshCarcinoma, Squamous Cell - Classification - Pathology - Surgeryen_US
dc.subject.meshHumansen_US
dc.subject.meshLaryngeal Neoplasms - Classification - Pathology - Surgeryen_US
dc.subject.meshLaryngectomyen_US
dc.subject.meshLymphatic Metastasisen_US
dc.subject.meshNeoplasm Recurrence, Localen_US
dc.subject.meshPrognosisen_US
dc.subject.meshTime Factorsen_US
dc.titleTumor clearance at resection margins in total laryngectomy. A clinicopathologic studyen_US
dc.typeArticleen_US
dc.identifier.emailWei, WI: hrmswwi@hku.hken_US
dc.identifier.authorityWei, WI=rp00323en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/1097-0142(19880601)61:11<2260::AID-CNCR2820611121>3.0.CO;2-C-
dc.identifier.pmid3365654-
dc.identifier.scopuseid_2-s2.0-0023926323en_US
dc.identifier.volume61en_US
dc.identifier.issue11en_US
dc.identifier.spage2260en_US
dc.identifier.epage2272en_US
dc.identifier.isiWOS:A1988N561900019-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLam, KH=7403657342en_US
dc.identifier.scopusauthoridLau, WF=7402933215en_US
dc.identifier.scopusauthoridWei, WI=7403321552en_US

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