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- Publisher Website: 10.1002/1097-0142(19880601)61:11<2260::AID-CNCR2820611121>3.0.CO;2-C
- Scopus: eid_2-s2.0-0023926323
- PMID: 3365654
- WOS: WOS:A1988N561900019
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Article: Tumor clearance at resection margins in total laryngectomy. A clinicopathologic study
Title | Tumor clearance at resection margins in total laryngectomy. A clinicopathologic study |
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Authors | |
Issue Date | 1988 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741 |
Citation | Cancer, 1988, v. 61 n. 11, p. 2260-2272 How to Cite? |
Abstract | The specimens from total laryngectomy performed in 70 patients were studied using the step-serial whole organ sectioning technique. Transverse histologic sections were taken and examined for minimum tumor clearance. The clinical status of patients for at least 4 years of observation was correlated with microscopic clearance of margins. The actual presence of tumor at the margins of resection was found in 21 (30%) of the specimens. The tumor was found to reach within 1 mm, 2 mm, and more than 2 mm from the margins in nine (13%), four (6%), and 36 (51%) specimens, respectively. The anterolateral margin was most commonly involved (19%), followed by the posterolateral (11%), postcricoid (7%), and upper (1.4%) margins. Local recurrence was found to be related to degree of clearance as 10 of 21 (48%) patients with no clearance and one of nine (11%) with 1 mm clearance had local failure. None of the patients with 2 mm clearance or more developed local recurrence. It is concluded that step-serial whole organ sectioning is an adequate method for thoroughly examining resection margins in laryngectomy specimens. |
Persistent Identifier | http://hdl.handle.net/10722/172588 |
ISSN | 2021 Impact Factor: 6.921 2020 SCImago Journal Rankings: 3.052 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lam, KH | en_US |
dc.contributor.author | Lau, WF | en_US |
dc.contributor.author | Wei, WI | en_US |
dc.date.accessioned | 2012-10-30T06:23:34Z | - |
dc.date.available | 2012-10-30T06:23:34Z | - |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | Cancer, 1988, v. 61 n. 11, p. 2260-2272 | en_US |
dc.identifier.issn | 0008-543X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/172588 | - |
dc.description.abstract | The specimens from total laryngectomy performed in 70 patients were studied using the step-serial whole organ sectioning technique. Transverse histologic sections were taken and examined for minimum tumor clearance. The clinical status of patients for at least 4 years of observation was correlated with microscopic clearance of margins. The actual presence of tumor at the margins of resection was found in 21 (30%) of the specimens. The tumor was found to reach within 1 mm, 2 mm, and more than 2 mm from the margins in nine (13%), four (6%), and 36 (51%) specimens, respectively. The anterolateral margin was most commonly involved (19%), followed by the posterolateral (11%), postcricoid (7%), and upper (1.4%) margins. Local recurrence was found to be related to degree of clearance as 10 of 21 (48%) patients with no clearance and one of nine (11%) with 1 mm clearance had local failure. None of the patients with 2 mm clearance or more developed local recurrence. It is concluded that step-serial whole organ sectioning is an adequate method for thoroughly examining resection margins in laryngectomy specimens. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741 | en_US |
dc.relation.ispartof | Cancer | en_US |
dc.subject.mesh | Carcinoma, Squamous Cell - Classification - Pathology - Surgery | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Laryngeal Neoplasms - Classification - Pathology - Surgery | en_US |
dc.subject.mesh | Laryngectomy | en_US |
dc.subject.mesh | Lymphatic Metastasis | en_US |
dc.subject.mesh | Neoplasm Recurrence, Local | en_US |
dc.subject.mesh | Prognosis | en_US |
dc.subject.mesh | Time Factors | en_US |
dc.title | Tumor clearance at resection margins in total laryngectomy. A clinicopathologic study | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wei, WI: hrmswwi@hku.hk | en_US |
dc.identifier.authority | Wei, WI=rp00323 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/1097-0142(19880601)61:11<2260::AID-CNCR2820611121>3.0.CO;2-C | - |
dc.identifier.pmid | 3365654 | - |
dc.identifier.scopus | eid_2-s2.0-0023926323 | en_US |
dc.identifier.volume | 61 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.spage | 2260 | en_US |
dc.identifier.epage | 2272 | en_US |
dc.identifier.isi | WOS:A1988N561900019 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lam, KH=7403657342 | en_US |
dc.identifier.scopusauthorid | Lau, WF=7402933215 | en_US |
dc.identifier.scopusauthorid | Wei, WI=7403321552 | en_US |
dc.identifier.issnl | 0008-543X | - |