File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Chronic gastric ulcers are not predisposed to tumor formation when exposed to a low dose of carcinogen

TitleChronic gastric ulcers are not predisposed to tumor formation when exposed to a low dose of carcinogen
Authors
Issue Date1986
PublisherElsevier Inc.. The Journal's web site is located at http://www.elsevier.com/locate/jsre
Citation
Journal Of Surgical Research, 1986, v. 41 n. 1, p. 58-64 How to Cite?
AbstractThe purpose of this experiment was to determine whether chronic gastric ulcers in the rat are predisposed to tumor formation when exposed to a usually noncarcinogenic dose of the carcinogen, N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG). Two groups of rats were prepared; one subjected to a standard ulcer-producing operation, the others as control. Both groups were given oral MNNG (100 mg/liter as drinking water) for 12 weeks, the carcinogen was then stopped and replaced with tap water, and the experiment terminated at 52 weeks. Results showed that a low dose of carcinogen (200 mg) did not induce tumor formation in any of the normal rats. In the presence of a chronic gastric ulcer, only intestinal metaplasia and hyperplastic glandular nodules were observed, but there were no gastric tumors. It is concluded that the presence of a chronic gastric ulcer did not increase the likelihood of gastric tumor formation in rats treated with a noncarcinogenic dose of the carcinogen MNNG.
Persistent Identifierhttp://hdl.handle.net/10722/172549
ISSN
2015 Impact Factor: 2.198
2015 SCImago Journal Rankings: 0.928
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSiu, KFen_HK
dc.contributor.authorWei, WIen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2012-10-30T06:23:21Z-
dc.date.available2012-10-30T06:23:21Z-
dc.date.issued1986en_HK
dc.identifier.citationJournal Of Surgical Research, 1986, v. 41 n. 1, p. 58-64en_HK
dc.identifier.issn0022-4804en_HK
dc.identifier.urihttp://hdl.handle.net/10722/172549-
dc.description.abstractThe purpose of this experiment was to determine whether chronic gastric ulcers in the rat are predisposed to tumor formation when exposed to a usually noncarcinogenic dose of the carcinogen, N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG). Two groups of rats were prepared; one subjected to a standard ulcer-producing operation, the others as control. Both groups were given oral MNNG (100 mg/liter as drinking water) for 12 weeks, the carcinogen was then stopped and replaced with tap water, and the experiment terminated at 52 weeks. Results showed that a low dose of carcinogen (200 mg) did not induce tumor formation in any of the normal rats. In the presence of a chronic gastric ulcer, only intestinal metaplasia and hyperplastic glandular nodules were observed, but there were no gastric tumors. It is concluded that the presence of a chronic gastric ulcer did not increase the likelihood of gastric tumor formation in rats treated with a noncarcinogenic dose of the carcinogen MNNG.en_HK
dc.languageengen_US
dc.publisherElsevier Inc.. The Journal's web site is located at http://www.elsevier.com/locate/jsreen_HK
dc.relation.ispartofJournal of Surgical Researchen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshCarcinogens - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastric Acid - Secretionen_US
dc.subject.meshGastrins - Blooden_US
dc.subject.meshLiver - Drug Effects - Pathologyen_US
dc.subject.meshMethylnitronitrosoguanidine - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshStomach - Drug Effects - Pathologyen_US
dc.subject.meshStomach Neoplasms - Etiologyen_US
dc.subject.meshStomach Ulcer - Complications - Pathologyen_US
dc.titleChronic gastric ulcers are not predisposed to tumor formation when exposed to a low dose of carcinogenen_HK
dc.typeArticleen_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0022-4804(86)90009-0-
dc.identifier.pmid3747498-
dc.identifier.scopuseid_2-s2.0-0022922509en_HK
dc.identifier.volume41en_HK
dc.identifier.issue1en_HK
dc.identifier.spage58en_HK
dc.identifier.epage64en_HK
dc.identifier.isiWOS:A1986E073300008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSiu, KF=24380342300en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats