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Article: Adjunctive benzodiazepine treatment of hospitalized schizophrenia patients in Asia from 2001 to 2008

TitleAdjunctive benzodiazepine treatment of hospitalized schizophrenia patients in Asia from 2001 to 2008
Authors
Issue Date2011
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PNP
Citation
International Journal Of Neuropsychopharmacology, 2011, v. 14 n. 6, p. 735-745 How to Cite?
AbstractBenzodiazepines are commonly prescribed to patients with schizophrenia in many countries, but as little is known about such treatment in Asia, we evaluated their adjunctive use for 6761 in-patients diagnosed with schizophrenia in nine Asian countries using a cross-sectional study design in 2001, 2004 and 2008. Multivariate logistic regression and multivariate linear regression analyses were performed to assess predictors of benzodiazepine use and dose, respectively. Overall, 54% of the patients received adjunctive benzodiazepines at an average daily dose equivalent to 30.3 mg diazepam, with minor changes over the years sampled. Benzodiazepine use was highest in Taiwan and Japan, lowest in Thailand and China, and was associated with fewer years ill, presence of delusions (OR 1.24), hallucinations (OR 1.22), disorganized speech (OR 1.17), social or occupational dysfunction (OR 1.16), and use of mood stabilizers (OR 3.15), antiparkinsonian (OR 1.79) or antidepressant drugs (OR 1.33), and lower doses of antipsychotics (all p=0.016 to <0.001). Benzodiazepine doses were highest in Taiwan and China, lowest in Korea and Singapore; higher doses were associated with being young, male, physically aggressive, receiving mood stabilizers, and having electroconvulsive treatment (all p=0.019 to <0.001). Benzodiazepine use was associated with neurological and systemic adverse effects. In conclusion, benzodiazepine use was common in Asian patients with schizophrenia. Predictors of benzodiazepine use and dose differed in this population. Critical clinical guidelines should be developed specifically for Asian countries to address sound practices in regard to use of benzodiazepines for psychotic disorders. © 2011 CINP.
Persistent Identifierhttp://hdl.handle.net/10722/171963
ISSN
2015 Impact Factor: 4.333
2015 SCImago Journal Rankings: 1.690
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTor, PCen_US
dc.contributor.authorNg, TPen_US
dc.contributor.authorYong, KHen_US
dc.contributor.authorSim, Ken_US
dc.contributor.authorXiang, YTen_US
dc.contributor.authorWang, CYen_US
dc.contributor.authorLee, EHMen_US
dc.contributor.authorFujii, Sen_US
dc.contributor.authorYang, SYen_US
dc.contributor.authorChong, MYen_US
dc.contributor.authorUngvari, GSen_US
dc.contributor.authorSi, Ten_US
dc.contributor.authorHe, YLen_US
dc.contributor.authorChung, EKen_US
dc.contributor.authorChee, KYen_US
dc.contributor.authorTrivedi, Jen_US
dc.contributor.authorUdomratn, Pen_US
dc.contributor.authorShinfuku, Nen_US
dc.contributor.authorKua, EHen_US
dc.contributor.authorTan, CHen_US
dc.contributor.authorSartorius, Nen_US
dc.contributor.authorBaldessarini, RJen_US
dc.date.accessioned2012-10-30T06:18:54Z-
dc.date.available2012-10-30T06:18:54Z-
dc.date.issued2011en_US
dc.identifier.citationInternational Journal Of Neuropsychopharmacology, 2011, v. 14 n. 6, p. 735-745en_US
dc.identifier.issn1461-1457en_US
dc.identifier.urihttp://hdl.handle.net/10722/171963-
dc.description.abstractBenzodiazepines are commonly prescribed to patients with schizophrenia in many countries, but as little is known about such treatment in Asia, we evaluated their adjunctive use for 6761 in-patients diagnosed with schizophrenia in nine Asian countries using a cross-sectional study design in 2001, 2004 and 2008. Multivariate logistic regression and multivariate linear regression analyses were performed to assess predictors of benzodiazepine use and dose, respectively. Overall, 54% of the patients received adjunctive benzodiazepines at an average daily dose equivalent to 30.3 mg diazepam, with minor changes over the years sampled. Benzodiazepine use was highest in Taiwan and Japan, lowest in Thailand and China, and was associated with fewer years ill, presence of delusions (OR 1.24), hallucinations (OR 1.22), disorganized speech (OR 1.17), social or occupational dysfunction (OR 1.16), and use of mood stabilizers (OR 3.15), antiparkinsonian (OR 1.79) or antidepressant drugs (OR 1.33), and lower doses of antipsychotics (all p=0.016 to <0.001). Benzodiazepine doses were highest in Taiwan and China, lowest in Korea and Singapore; higher doses were associated with being young, male, physically aggressive, receiving mood stabilizers, and having electroconvulsive treatment (all p=0.019 to <0.001). Benzodiazepine use was associated with neurological and systemic adverse effects. In conclusion, benzodiazepine use was common in Asian patients with schizophrenia. Predictors of benzodiazepine use and dose differed in this population. Critical clinical guidelines should be developed specifically for Asian countries to address sound practices in regard to use of benzodiazepines for psychotic disorders. © 2011 CINP.en_US
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PNPen_US
dc.relation.ispartofInternational Journal of Neuropsychopharmacologyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAsiaen_US
dc.subject.meshBenzodiazepines - Administration & Dosage - Adverse Effects - Therapeutic Useen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDiagnostic And Statistical Manual Of Mental Disordersen_US
dc.subject.meshDrug Therapy, Combination - Adverse Effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHospitalizationen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPhysician's Practice Patternsen_US
dc.subject.meshPractice Guidelines As Topicen_US
dc.subject.meshPsychotropic Drugs - Administration & Dosage - Adverse Effects - Therapeutic Useen_US
dc.subject.meshSchizophrenia - Drug Therapy - Physiopathologyen_US
dc.subject.meshStatistics As Topicen_US
dc.subject.meshYoung Adulten_US
dc.titleAdjunctive benzodiazepine treatment of hospitalized schizophrenia patients in Asia from 2001 to 2008en_US
dc.typeArticleen_US
dc.identifier.emailLee, EHM:edwinlhm@hku.hken_US
dc.identifier.authorityLee, EHM=rp01575en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1017/S146114571000163Xen_US
dc.identifier.pmid21294941-
dc.identifier.scopuseid_2-s2.0-79958863366en_US
dc.identifier.hkuros206336-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79958863366&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue6en_US
dc.identifier.spage735en_US
dc.identifier.epage745en_US
dc.identifier.isiWOS:000291611000002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridTor, PC=23494282600en_US
dc.identifier.scopusauthoridNg, TP=7402229981en_US
dc.identifier.scopusauthoridYong, KH=37054832300en_US
dc.identifier.scopusauthoridSim, K=8513485500en_US
dc.identifier.scopusauthoridXiang, YT=35241398400en_US
dc.identifier.scopusauthoridWang, CY=47961486300en_US
dc.identifier.scopusauthoridLee, EHM=7406967099en_US
dc.identifier.scopusauthoridFujii, S=7401814463en_US
dc.identifier.scopusauthoridYang, SY=25958514300en_US
dc.identifier.scopusauthoridChong, MY=7102632108en_US
dc.identifier.scopusauthoridUngvari, GS=7006092063en_US
dc.identifier.scopusauthoridSi, T=6701400479en_US
dc.identifier.scopusauthoridHe, YL=35313337300en_US
dc.identifier.scopusauthoridChung, EK=7202734618en_US
dc.identifier.scopusauthoridChee, KY=54909902300en_US
dc.identifier.scopusauthoridTrivedi, J=7005836490en_US
dc.identifier.scopusauthoridUdomratn, P=6602459819en_US
dc.identifier.scopusauthoridShinfuku, N=7003855366en_US
dc.identifier.scopusauthoridKua, EH=7006748699en_US
dc.identifier.scopusauthoridTan, CH=7402817882en_US
dc.identifier.scopusauthoridSartorius, N=7102159482en_US
dc.identifier.scopusauthoridBaldessarini, RJ=7203008029en_US

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