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Article: The menstrual cycle and platelet 5-HT uptake

TitleThe menstrual cycle and platelet 5-HT uptake
Authors
Issue Date1985
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.psychosomaticmedicine.org/
Citation
Psychosomatic Medicine, 1985, v. 47 n. 4, p. 352-362 How to Cite?
AbstractThe association between the onset of depressive illness and the paramenstruum has been reported. In the present study, we looked at changes in platelet 5-HT uptake in six healthy, regularly menstruating subjects on days 1, 10, and 24 of three consecutive menstrual cycles to explore possible biochemical bases for mood changes associated with menstruation. Platelet 5-hydroxytryptamine (5-HT) uptake was determined by suspension of platelet pellets in 0.5-5 μM hydroxy [G- 3H] tryptamine ([ 3H]-5-HT) creatinine sulfate solution at 37° C and measurement of radioactivity of [ 3H]-5-HT in the platelets using liquid scintillation counting. Mood changes were measured using the Moos Menstruation Distress Questionnaire and the Spielberger State Anxiety Scale. Analysis of variance and trend analysis revealed significant elevation of K(m) and V(max) on day 24 of the cycle, which was consistent across the three menstrual cycles studied. A significant linear rise of 'negative affect' across each cycle peaking on day 1 was detected. 'Water retention' and 'behavioral change' also peaked on day 1. No significant correlation, however, was obtained between the mood scores and platelet 5-HT uptake. These findings are discussed.
Persistent Identifierhttp://hdl.handle.net/10722/171872
ISSN
2015 Impact Factor: 3.638
2015 SCImago Journal Rankings: 1.789
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTam, WYKen_US
dc.contributor.authorChan, MYen_US
dc.contributor.authorLee, PHKen_US
dc.date.accessioned2012-10-30T06:18:07Z-
dc.date.available2012-10-30T06:18:07Z-
dc.date.issued1985en_US
dc.identifier.citationPsychosomatic Medicine, 1985, v. 47 n. 4, p. 352-362en_US
dc.identifier.issn0033-3174en_US
dc.identifier.urihttp://hdl.handle.net/10722/171872-
dc.description.abstractThe association between the onset of depressive illness and the paramenstruum has been reported. In the present study, we looked at changes in platelet 5-HT uptake in six healthy, regularly menstruating subjects on days 1, 10, and 24 of three consecutive menstrual cycles to explore possible biochemical bases for mood changes associated with menstruation. Platelet 5-hydroxytryptamine (5-HT) uptake was determined by suspension of platelet pellets in 0.5-5 μM hydroxy [G- 3H] tryptamine ([ 3H]-5-HT) creatinine sulfate solution at 37° C and measurement of radioactivity of [ 3H]-5-HT in the platelets using liquid scintillation counting. Mood changes were measured using the Moos Menstruation Distress Questionnaire and the Spielberger State Anxiety Scale. Analysis of variance and trend analysis revealed significant elevation of K(m) and V(max) on day 24 of the cycle, which was consistent across the three menstrual cycles studied. A significant linear rise of 'negative affect' across each cycle peaking on day 1 was detected. 'Water retention' and 'behavioral change' also peaked on day 1. No significant correlation, however, was obtained between the mood scores and platelet 5-HT uptake. These findings are discussed.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.psychosomaticmedicine.org/en_US
dc.relation.ispartofPsychosomatic Medicineen_US
dc.subject.meshAdulten_US
dc.subject.meshBlood Platelets - Metabolismen_US
dc.subject.meshDepressive Disorder - Physiopathologyen_US
dc.subject.meshEmotions - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMenstrual Cycleen_US
dc.subject.meshSerotonin - Blooden_US
dc.titleThe menstrual cycle and platelet 5-HT uptakeen_US
dc.typeArticleen_US
dc.identifier.emailTam, WYK:wwytam@hku.hken_US
dc.identifier.authorityTam, WYK=rp00301en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00006842-198507000-00005-
dc.identifier.pmid4023163-
dc.identifier.scopuseid_2-s2.0-0022416440en_US
dc.identifier.volume47en_US
dc.identifier.issue4en_US
dc.identifier.spage352en_US
dc.identifier.epage362en_US
dc.identifier.isiWOS:A1985ANA4900005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTam, WYK=36961691000en_US
dc.identifier.scopusauthoridChan, MY=7402598142en_US
dc.identifier.scopusauthoridLee, PHK=7406117057en_US

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