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Article: Adrenomedullin inhibits norepinephrine-induced contraction of rat seminal vesicle

TitleAdrenomedullin inhibits norepinephrine-induced contraction of rat seminal vesicle
Authors
Issue Date2012
PublisherExcerpta Medica, Inc. The Journal's web site is located at http://www.elsevier.com/locate/urology
Citation
Urology, 2012, v. 80 n. 1, p. 224.e1-224.e5 How to Cite?
AbstractObjective: To investigate the effect of adrenomedullin (ADM) on seminal vesicle smooth muscle contractions in the rat and the specific receptor involved. Whether it was dependent on the nitric oxidant pathway was also investigated. Methods: The seminal vesicles from Sprague-Dawley rats aged 8-10 weeks were incubated in Kreb's solution. Using an organ bath technique, the contraction of the seminal vesicle in response to norepinephrine (NE) and ADM was recorded, in the presence or absence of an ADM receptor blocker (hADM22-52), a calcitonin-gene-related peptide (CGRP) receptor blocker (hCGRP8-37), and l-NG-nitroarginine methyl ester, an endothelial nitric oxide synthase inhibitor. The basal tone, amplitude, and frequency of contraction were measured after incubation with the drugs. Results: The results showed that the contraction induced by NE was effectively inhibited by ADM. The basal tone, amplitude, and frequency all decreased. The ADM effects on the NE-induced increases in basal tone and amplitude were completely blocked by hCGRP8-37, the CGRP receptor antagonist, but were not abolished by l-NG-nitroarginine methyl ester. Conclusion: The findings have demonstrated that in the seminal vesicle the inhibitory effect of ADM on NE-induced contraction was mediated by the CGRP receptor but not by nitric oxide production. © 2012 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/171792
ISSN
2015 Impact Factor: 2.187
2015 SCImago Journal Rankings: 1.121
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiao, SBen_US
dc.contributor.authorO, WSen_US
dc.contributor.authorTang, Fen_US
dc.date.accessioned2012-10-30T06:17:08Z-
dc.date.available2012-10-30T06:17:08Z-
dc.date.issued2012en_US
dc.identifier.citationUrology, 2012, v. 80 n. 1, p. 224.e1-224.e5en_US
dc.identifier.issn0090-4295en_US
dc.identifier.urihttp://hdl.handle.net/10722/171792-
dc.description.abstractObjective: To investigate the effect of adrenomedullin (ADM) on seminal vesicle smooth muscle contractions in the rat and the specific receptor involved. Whether it was dependent on the nitric oxidant pathway was also investigated. Methods: The seminal vesicles from Sprague-Dawley rats aged 8-10 weeks were incubated in Kreb's solution. Using an organ bath technique, the contraction of the seminal vesicle in response to norepinephrine (NE) and ADM was recorded, in the presence or absence of an ADM receptor blocker (hADM22-52), a calcitonin-gene-related peptide (CGRP) receptor blocker (hCGRP8-37), and l-NG-nitroarginine methyl ester, an endothelial nitric oxide synthase inhibitor. The basal tone, amplitude, and frequency of contraction were measured after incubation with the drugs. Results: The results showed that the contraction induced by NE was effectively inhibited by ADM. The basal tone, amplitude, and frequency all decreased. The ADM effects on the NE-induced increases in basal tone and amplitude were completely blocked by hCGRP8-37, the CGRP receptor antagonist, but were not abolished by l-NG-nitroarginine methyl ester. Conclusion: The findings have demonstrated that in the seminal vesicle the inhibitory effect of ADM on NE-induced contraction was mediated by the CGRP receptor but not by nitric oxide production. © 2012 Elsevier Inc.en_US
dc.languageengen_US
dc.publisherExcerpta Medica, Inc. The Journal's web site is located at http://www.elsevier.com/locate/urologyen_US
dc.relation.ispartofUrologyen_US
dc.titleAdrenomedullin inhibits norepinephrine-induced contraction of rat seminal vesicleen_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.identifier.authorityO, WS=rp00315-
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.urology.2012.03.036en_US
dc.identifier.pmid22626578-
dc.identifier.scopuseid_2-s2.0-84862977263en_US
dc.identifier.hkuros204327-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84862977263&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume80en_US
dc.identifier.issue1en_US
dc.identifier.spage224.e1en_US
dc.identifier.epage224.e5en_US
dc.identifier.eissn1527-9995-
dc.identifier.isiWOS:000305957500059-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLiao, SB=36170881600en_US
dc.identifier.scopusauthoridO, WS=55266614600en_US
dc.identifier.scopusauthoridTang, F=7201979770en_US
dc.identifier.citeulike10705131-

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