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Article: Excitatory effect of histamine on rat spinal motoneurons by activation of both H 1 and H 2 receptors in vitro

TitleExcitatory effect of histamine on rat spinal motoneurons by activation of both H 1 and H 2 receptors in vitro
Authors
Issue Date2012
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34828
Citation
Journal Of Neuroscience Research, 2012, v. 90 n. 1, p. 132-142 How to Cite?
AbstractThe central histaminergic nervous system, originating from the tuberomammillary nucleus of the hypothalamus, widely innervates almost the whole brain as well as the spinal cord. However, the effect of histamine on spinal motoneurons, the final common path for motor control, is still unknown. By using 8-14-day-old rat spinal slice preparations and intracellular recordings, the effect of histamine on motoneurons in lumbar spinal cord and the underlying mechanisms were studied. Bath application of histamine (30-300 μM) induced a membrane depolarization in the majority of recorded spinal motoneurons (78/90, 86%). Perfusing slices with tetrodotoxin or low-Ca 2+/high-Mg 2+ medium did not block the histamine-induced excitation, indicating a direct postsynaptic action of histamine on motoneurons. Separate application of the selective histamine H 1 receptor antagonist mepyramine or the selective histamine H 2 receptor antagonist ranitidine partially suppressed the histamine-induced excitation, whereas a combination of ranitidine and mepyramine totally blocked the excitatory effect of histamine on motoneurons. On the other hand, both the selective histamine H 1 receptor agonist 2-pyridylethylamine and the selective histamine H 2 receptor agonist dimaprit mimicked the excitation of histamine on spinal motoneurons. These agonist-induced excitations were also blocked by mepyramine or ranitidine. Furthermore, histamine affected membrane input resistance and potentiated repetitive firing behavior of spinal motoneurons. These results demonstrate that histamine excites rat spinal motoneurons via the histamine H 1 and H 2 receptors and increases their excitability, suggesting that the hypothalamospinal histaminergic fibers may directly modulate final motor outputs and actively regulate ongoing motor execution andspinal motor reflexes. © 2011 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/171788
ISSN
2015 Impact Factor: 2.689
2015 SCImago Journal Rankings: 1.261
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, GYen_US
dc.contributor.authorHan, XHen_US
dc.contributor.authorZhuang, QXen_US
dc.contributor.authorZhang, Jen_US
dc.contributor.authorYung, WHen_US
dc.contributor.authorChan, YSen_US
dc.contributor.authorZhu, JNen_US
dc.contributor.authorWang, JJen_US
dc.date.accessioned2012-10-30T06:17:07Z-
dc.date.available2012-10-30T06:17:07Z-
dc.date.issued2012en_US
dc.identifier.citationJournal Of Neuroscience Research, 2012, v. 90 n. 1, p. 132-142en_US
dc.identifier.issn0360-4012en_US
dc.identifier.urihttp://hdl.handle.net/10722/171788-
dc.description.abstractThe central histaminergic nervous system, originating from the tuberomammillary nucleus of the hypothalamus, widely innervates almost the whole brain as well as the spinal cord. However, the effect of histamine on spinal motoneurons, the final common path for motor control, is still unknown. By using 8-14-day-old rat spinal slice preparations and intracellular recordings, the effect of histamine on motoneurons in lumbar spinal cord and the underlying mechanisms were studied. Bath application of histamine (30-300 μM) induced a membrane depolarization in the majority of recorded spinal motoneurons (78/90, 86%). Perfusing slices with tetrodotoxin or low-Ca 2+/high-Mg 2+ medium did not block the histamine-induced excitation, indicating a direct postsynaptic action of histamine on motoneurons. Separate application of the selective histamine H 1 receptor antagonist mepyramine or the selective histamine H 2 receptor antagonist ranitidine partially suppressed the histamine-induced excitation, whereas a combination of ranitidine and mepyramine totally blocked the excitatory effect of histamine on motoneurons. On the other hand, both the selective histamine H 1 receptor agonist 2-pyridylethylamine and the selective histamine H 2 receptor agonist dimaprit mimicked the excitation of histamine on spinal motoneurons. These agonist-induced excitations were also blocked by mepyramine or ranitidine. Furthermore, histamine affected membrane input resistance and potentiated repetitive firing behavior of spinal motoneurons. These results demonstrate that histamine excites rat spinal motoneurons via the histamine H 1 and H 2 receptors and increases their excitability, suggesting that the hypothalamospinal histaminergic fibers may directly modulate final motor outputs and actively regulate ongoing motor execution andspinal motor reflexes. © 2011 Wiley Periodicals, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34828en_US
dc.relation.ispartofJournal of Neuroscience Researchen_US
dc.subject.meshAction Potentials - Drug Effectsen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshBiophysicsen_US
dc.subject.meshCalcium Channel Blockers - Pharmacologyen_US
dc.subject.meshDimaprit - Pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshElectric Stimulationen_US
dc.subject.meshHistamine - Pharmacologyen_US
dc.subject.meshHistamine Agonists - Pharmacologyen_US
dc.subject.meshHistamine H2 Antagonists - Pharmacologyen_US
dc.subject.meshMotor Neurons - Drug Effectsen_US
dc.subject.meshPatch-Clamp Techniquesen_US
dc.subject.meshPyridines - Pharmacologyen_US
dc.subject.meshRanitidine - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshReceptors, Histamine H1 - Metabolismen_US
dc.subject.meshReceptors, Histamine H2 - Metabolismen_US
dc.subject.meshSpinal Cord - Cytologyen_US
dc.subject.meshTetrodotoxin - Pharmacologyen_US
dc.titleExcitatory effect of histamine on rat spinal motoneurons by activation of both H 1 and H 2 receptors in vitroen_US
dc.typeArticleen_US
dc.identifier.emailChan, YS:yschan@hkucc.hku.hken_US
dc.identifier.authorityChan, YS=rp00318en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/jnr.22730en_US
dc.identifier.pmid21922515-
dc.identifier.scopuseid_2-s2.0-81255171602en_US
dc.identifier.hkuros209192-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-81255171602&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume90en_US
dc.identifier.issue1en_US
dc.identifier.spage132en_US
dc.identifier.epage142en_US
dc.identifier.isiWOS:000297951100012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWu, GY=54421480000en_US
dc.identifier.scopusauthoridHan, XH=26633668400en_US
dc.identifier.scopusauthoridZhuang, QX=51162409800en_US
dc.identifier.scopusauthoridZhang, J=36080120900en_US
dc.identifier.scopusauthoridYung, WH=7103137893en_US
dc.identifier.scopusauthoridChan, YS=7403676627en_US
dc.identifier.scopusauthoridZhu, JN=9279857000en_US
dc.identifier.scopusauthoridWang, JJ=36067112900en_US

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