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Article: Corticothalamic synchronization leads to c-fos expression in the auditory thalamus

TitleCorticothalamic synchronization leads to c-fos expression in the auditory thalamus
Authors
Issue Date2007
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2007, v. 104 n. 28, p. 11802-11807 How to Cite?
AbstractIn this study, we investigated the relationship between c-fos expression in the auditory thalamus and corticofugal activation. The contribution of neurotransmitters and related receptors, the involvement of thalamic reticular nucleus (TRN), and the role of neuronal firing patterns in this process were also examined. The principal nuclei of the medial geniculate body (MGB) showed c-fos expression when the auditory cortex (AC) was activated by direct injection of bicuculline methobromide. However, no expression was detectable with acoustic stimuli alone. This indicated that c-fos expression in the principal nuclei of the MGB was triggered by the corticofugal projection, c-fos expression could be elicited in the MGB by direct injection of glutamate. Direct administration of acetylcholine, alternatively, had no effect. Bicuculline methobromide injection in the AC also triggered synchronized oscillatory activities sequentially in the AC and MGB. Cortically induced c-fos expression in the MGB was not mediated by a pathway involving the TRN because it remained intact after a TRN lesion with kainic acid. The present results also conclude that c-fos expression is not simply associated with firing rate, but also with neuronal firing pattern. Burst firings that are synchronized with the cortical oscillations are proposed to lead to c-fos expression in the principal nuclei of the MGB. © 2007 by The National Academy of Sciences of the USA.
Persistent Identifierhttp://hdl.handle.net/10722/171759
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYi, PGen_US
dc.contributor.authorSun, Xen_US
dc.contributor.authorLi, Cen_US
dc.contributor.authorNing, QWen_US
dc.contributor.authorChan, YSen_US
dc.contributor.authorHe, Jen_US
dc.date.accessioned2012-10-30T06:16:50Z-
dc.date.available2012-10-30T06:16:50Z-
dc.date.issued2007en_US
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2007, v. 104 n. 28, p. 11802-11807en_US
dc.identifier.issn0027-8424en_US
dc.identifier.urihttp://hdl.handle.net/10722/171759-
dc.description.abstractIn this study, we investigated the relationship between c-fos expression in the auditory thalamus and corticofugal activation. The contribution of neurotransmitters and related receptors, the involvement of thalamic reticular nucleus (TRN), and the role of neuronal firing patterns in this process were also examined. The principal nuclei of the medial geniculate body (MGB) showed c-fos expression when the auditory cortex (AC) was activated by direct injection of bicuculline methobromide. However, no expression was detectable with acoustic stimuli alone. This indicated that c-fos expression in the principal nuclei of the MGB was triggered by the corticofugal projection, c-fos expression could be elicited in the MGB by direct injection of glutamate. Direct administration of acetylcholine, alternatively, had no effect. Bicuculline methobromide injection in the AC also triggered synchronized oscillatory activities sequentially in the AC and MGB. Cortically induced c-fos expression in the MGB was not mediated by a pathway involving the TRN because it remained intact after a TRN lesion with kainic acid. The present results also conclude that c-fos expression is not simply associated with firing rate, but also with neuronal firing pattern. Burst firings that are synchronized with the cortical oscillations are proposed to lead to c-fos expression in the principal nuclei of the MGB. © 2007 by The National Academy of Sciences of the USA.en_US
dc.languageengen_US
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_US
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.subject.meshAcoustic Stimulationen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAuditory Cortex - Metabolism - Physiologyen_US
dc.subject.meshAuditory Pathways - Metabolism - Physiologyen_US
dc.subject.meshGeniculate Bodies - Metabolism - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshProto-Oncogene Proteins C-Fos - Biosynthesis - Geneticsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSynaptic Transmission - Physiologyen_US
dc.subject.meshThalamic Nuclei - Physiologyen_US
dc.subject.meshThalamus - Metabolism - Physiologyen_US
dc.titleCorticothalamic synchronization leads to c-fos expression in the auditory thalamusen_US
dc.typeArticleen_US
dc.identifier.emailChan, YS:yschan@hkucc.hku.hken_US
dc.identifier.authorityChan, YS=rp00318en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1073/pnas.0701302104en_US
dc.identifier.pmid17606925-
dc.identifier.scopuseid_2-s2.0-34547446560en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547446560&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume104en_US
dc.identifier.issue28en_US
dc.identifier.spage11802en_US
dc.identifier.epage11807en_US
dc.identifier.isiWOS:000248063400052-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYi, PG=18039144900en_US
dc.identifier.scopusauthoridSun, X=7405621422en_US
dc.identifier.scopusauthoridLi, C=8055499400en_US
dc.identifier.scopusauthoridNing, QW=18038102300en_US
dc.identifier.scopusauthoridChan, YS=7403676627en_US
dc.identifier.scopusauthoridHe, J=7404984971en_US

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