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Article: Nitric oxide modulation of voltage-gated calcium current by S-nitrosylation and cGMP pathway in cultured rat hippocampal neurons

TitleNitric oxide modulation of voltage-gated calcium current by S-nitrosylation and cGMP pathway in cultured rat hippocampal neurons
Authors
Issue Date2007
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2007, v. 359 n. 3, p. 481-485 How to Cite?
AbstractNitric oxide (NO) plays an important role in many physiological and pathophysiological processes in the brain. In this study, we examined the mechanistic effects of an NO donor, diethylenetriamine/nitric oxide adduct (DETA/NO) on the voltage-gated calcium currents in cultured rat hippocampal neurons. DETA/NO stimulated the calcium currents and slightly increased the channel sensitivity to depolarizing voltages. The effect of DETA/NO on the calcium current was blocked by either depleting the NO in DETA/NO or by pretreating the neurons with NEM, a thiol-specific alkylating agent, suggesting an involvement of S-nitrosylation in the current response to NO. In addition, activation of the cGMP pathway by 8-Br-cGMP inhibited the calcium current in the neurons. Also, inhibition of guanylyl cyclase by 1H-[1,2,4] oxadiazolo [4,3-a] quinoxalin-1-one (ODQ) increased the current response to DETA/NO. Taken together, our results demonstrate that both S-nitrosylation and cGMP pathway are involved in the NO modulation of the hippocampal calcium current. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/171757
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJian, Ken_US
dc.contributor.authorChen, Men_US
dc.contributor.authorCao, Xen_US
dc.contributor.authorZhu, XHen_US
dc.contributor.authorFung, MLen_US
dc.contributor.authorGao, TMen_US
dc.date.accessioned2012-10-30T06:16:49Z-
dc.date.available2012-10-30T06:16:49Z-
dc.date.issued2007en_US
dc.identifier.citationBiochemical And Biophysical Research Communications, 2007, v. 359 n. 3, p. 481-485en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/171757-
dc.description.abstractNitric oxide (NO) plays an important role in many physiological and pathophysiological processes in the brain. In this study, we examined the mechanistic effects of an NO donor, diethylenetriamine/nitric oxide adduct (DETA/NO) on the voltage-gated calcium currents in cultured rat hippocampal neurons. DETA/NO stimulated the calcium currents and slightly increased the channel sensitivity to depolarizing voltages. The effect of DETA/NO on the calcium current was blocked by either depleting the NO in DETA/NO or by pretreating the neurons with NEM, a thiol-specific alkylating agent, suggesting an involvement of S-nitrosylation in the current response to NO. In addition, activation of the cGMP pathway by 8-Br-cGMP inhibited the calcium current in the neurons. Also, inhibition of guanylyl cyclase by 1H-[1,2,4] oxadiazolo [4,3-a] quinoxalin-1-one (ODQ) increased the current response to DETA/NO. Taken together, our results demonstrate that both S-nitrosylation and cGMP pathway are involved in the NO modulation of the hippocampal calcium current. © 2007 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_US
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium Channels - Metabolismen_US
dc.subject.meshCyclic Gmp - Metabolismen_US
dc.subject.meshHippocampus - Drug Effects - Metabolismen_US
dc.subject.meshIon Channel Gatingen_US
dc.subject.meshNeurons - Drug Effects - Metabolismen_US
dc.subject.meshNitric Oxide - Metabolismen_US
dc.subject.meshNitrogen - Metabolismen_US
dc.subject.meshPolyamines - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSignal Transductionen_US
dc.subject.meshTissue Culture Techniquesen_US
dc.titleNitric oxide modulation of voltage-gated calcium current by S-nitrosylation and cGMP pathway in cultured rat hippocampal neuronsen_US
dc.typeArticleen_US
dc.identifier.emailFung, ML:fungml@hkucc.hku.hken_US
dc.identifier.authorityFung, ML=rp00433en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.bbrc.2007.05.113en_US
dc.identifier.pmid17544367-
dc.identifier.scopuseid_2-s2.0-34250172430en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34250172430&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume359en_US
dc.identifier.issue3en_US
dc.identifier.spage481en_US
dc.identifier.epage485en_US
dc.identifier.isiWOS:000247582500014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridJian, K=36929518800en_US
dc.identifier.scopusauthoridChen, M=35285618500en_US
dc.identifier.scopusauthoridCao, X=36985373700en_US
dc.identifier.scopusauthoridZhu, XH=7406186945en_US
dc.identifier.scopusauthoridFung, ML=7101955092en_US
dc.identifier.scopusauthoridGao, TM=7101845480en_US

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