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Article: Endothelial m, and m3 muscarinic receptor subtypes mediate acetylcholine - induced relaxation in rat tail artery

TitleEndothelial m, and m3 muscarinic receptor subtypes mediate acetylcholine - induced relaxation in rat tail artery
Authors
Issue Date1996
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
Faseb Journal, 1996, v. 10 n. 3, p. A701 How to Cite?
AbstractThe relaxation, by acetylchohne (ACh), of an agonist (eg phenylephnne: PE)-induced contraction is an accepted method for identifying a functional endothelmm in vascular tissues. The muscannic receptor subtype that mediates ACh-mduced relaxation varies from tissue to tissue and has not been identified in the ventral rat tail artery (RTA) We, therefore, investigated the receptor subtypes that are involved in ACh- induced relaxation of the RTA Perfused (2.5ml/min) segments (proximal third) of ventral RTAs from male SD-rats (300-350g) precontracted with PE (luM) were exposed to (a) graded concentrations of ACh in the presence or absence of muscannic receptor antagonists (pirenzepine (Pnz) for MI or 4-diphenylacetoxy-N-methylpipendine methiodide (4-DAMP) for M.) and (b): graded concentrations of a muscannic antagonist in the presence or absence of ACh Endothelium was either left intact or denuded with saponin or functionally inactivated with nitro-L-arginine methyl ester (L-NAME) ACh-induced relaxation was observed only in endothelmm- intact preparations but not in saponin- or L-NAME- treated preparations. Pnz or 4-DAMP alone had no effect on PE- induced contraction in all the preparations but in the presence of ACh Pnz or 4-DAMP con cent ration- dependently reversed ACh- induced relaxation in endothehummtact RTAs This was not observed in any of the saponin- or L-NAME-treated artenes It is concluded that endotheha! MI and Mi muscarimc receptors are involved in ACh- induced relaxation of the RTA.
Persistent Identifierhttp://hdl.handle.net/10722/171748
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorAchike, FIen_US
dc.contributor.authorKwan, CYen_US
dc.contributor.authorBallard, HJen_US
dc.date.accessioned2012-10-30T06:16:46Z-
dc.date.available2012-10-30T06:16:46Z-
dc.date.issued1996en_US
dc.identifier.citationFaseb Journal, 1996, v. 10 n. 3, p. A701en_US
dc.identifier.issn0892-6638en_US
dc.identifier.urihttp://hdl.handle.net/10722/171748-
dc.description.abstractThe relaxation, by acetylchohne (ACh), of an agonist (eg phenylephnne: PE)-induced contraction is an accepted method for identifying a functional endothelmm in vascular tissues. The muscannic receptor subtype that mediates ACh-mduced relaxation varies from tissue to tissue and has not been identified in the ventral rat tail artery (RTA) We, therefore, investigated the receptor subtypes that are involved in ACh- induced relaxation of the RTA Perfused (2.5ml/min) segments (proximal third) of ventral RTAs from male SD-rats (300-350g) precontracted with PE (luM) were exposed to (a) graded concentrations of ACh in the presence or absence of muscannic receptor antagonists (pirenzepine (Pnz) for MI or 4-diphenylacetoxy-N-methylpipendine methiodide (4-DAMP) for M.) and (b): graded concentrations of a muscannic antagonist in the presence or absence of ACh Endothelium was either left intact or denuded with saponin or functionally inactivated with nitro-L-arginine methyl ester (L-NAME) ACh-induced relaxation was observed only in endothelmm- intact preparations but not in saponin- or L-NAME- treated preparations. Pnz or 4-DAMP alone had no effect on PE- induced contraction in all the preparations but in the presence of ACh Pnz or 4-DAMP con cent ration- dependently reversed ACh- induced relaxation in endothehummtact RTAs This was not observed in any of the saponin- or L-NAME-treated artenes It is concluded that endotheha! MI and Mi muscarimc receptors are involved in ACh- induced relaxation of the RTA.en_US
dc.languageengen_US
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/en_US
dc.relation.ispartofFASEB Journalen_US
dc.titleEndothelial m, and m3 muscarinic receptor subtypes mediate acetylcholine - induced relaxation in rat tail arteryen_US
dc.typeArticleen_US
dc.identifier.emailBallard, HJ:ballard@hkucc.hku.hken_US
dc.identifier.authorityBallard, HJ=rp00367en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33749310591en_US
dc.identifier.volume10en_US
dc.identifier.issue3en_US
dc.identifier.spageA701en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridAchike, FI=6701844593en_US
dc.identifier.scopusauthoridKwan, CY=7201421224en_US
dc.identifier.scopusauthoridBallard, HJ=7005286310en_US

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