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Article: The gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl4-induced rat liver cirrhosis

TitleThe gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl4-induced rat liver cirrhosis
Authors
Issue Date2006
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/regpep
Citation
Regulatory Peptides, 2006, v. 135 n. 1-2, p. 69-77 How to Cite?
AbstractThis study was undertaken to determine AM expression in carbon tetrachloride (CCl4)-induced liver cirrhosis developed with peritoneal ascites. Sprague-Dawley rats received subcutaneous injections of CCl4 twice weekly in olive oil (1:1, 0.3 ml per kg body weight) for 6 or 12 weeks until ascites developed, or saline in olive oil as control. At 6 weeks, fibrosis developed and at 12 weeks cirrhosis developed with ascites formation. At both 6 and 12 weeks, increases in plasma renin and AM were evident, as was the gene expression of AM. At 12 weeks after CCl4 injection, the gene expression of calcitonin-like-receptor (CRLR) and receptor activity modifying proteins (RAMP1, RAMP2 and RAMP3) were all elevated when compared to the control. The results suggest that liver cirrhosis increases mRNA expressions of AM, CRLR and RAMP1, RAMP2 and RAMP3 and that the increase in AM gene expression precedes the development of cirrhosis. The increase in AM synthesis as reflected by an increase in AM gene expression, together with a lack of increase in AM peptide at both 6 and 12 weeks may suggest an elevation of AM release. Given the potent vasodilatory action of AM, the increase in the synthesis and release of AM in the cirrhotic liver may also contribute to peripheral vasodilatation in liver cirrhosis. © 2006 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/171744
ISSN
2015 Impact Factor: 1.813
2015 SCImago Journal Rankings: 0.915
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHwang, ISSen_US
dc.contributor.authorTang, Fen_US
dc.contributor.authorLeung, PPen_US
dc.contributor.authorLi, YYen_US
dc.contributor.authorFan, STen_US
dc.contributor.authorLuk, JMCen_US
dc.date.accessioned2012-10-30T06:16:44Z-
dc.date.available2012-10-30T06:16:44Z-
dc.date.issued2006en_US
dc.identifier.citationRegulatory Peptides, 2006, v. 135 n. 1-2, p. 69-77en_US
dc.identifier.issn0167-0115en_US
dc.identifier.urihttp://hdl.handle.net/10722/171744-
dc.description.abstractThis study was undertaken to determine AM expression in carbon tetrachloride (CCl4)-induced liver cirrhosis developed with peritoneal ascites. Sprague-Dawley rats received subcutaneous injections of CCl4 twice weekly in olive oil (1:1, 0.3 ml per kg body weight) for 6 or 12 weeks until ascites developed, or saline in olive oil as control. At 6 weeks, fibrosis developed and at 12 weeks cirrhosis developed with ascites formation. At both 6 and 12 weeks, increases in plasma renin and AM were evident, as was the gene expression of AM. At 12 weeks after CCl4 injection, the gene expression of calcitonin-like-receptor (CRLR) and receptor activity modifying proteins (RAMP1, RAMP2 and RAMP3) were all elevated when compared to the control. The results suggest that liver cirrhosis increases mRNA expressions of AM, CRLR and RAMP1, RAMP2 and RAMP3 and that the increase in AM gene expression precedes the development of cirrhosis. The increase in AM synthesis as reflected by an increase in AM gene expression, together with a lack of increase in AM peptide at both 6 and 12 weeks may suggest an elevation of AM release. Given the potent vasodilatory action of AM, the increase in the synthesis and release of AM in the cirrhotic liver may also contribute to peripheral vasodilatation in liver cirrhosis. © 2006 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/regpepen_US
dc.relation.ispartofRegulatory Peptidesen_US
dc.rightsRegulatory Peptides. Copyright © Elsevier BV.-
dc.subject.meshAdrenomedullin - Genetics - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcitonin Receptor-Like Proteinen_US
dc.subject.meshCarbon Tetrachloride - Toxicityen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshIntracellular Signaling Peptides And Proteins - Genetics - Metabolismen_US
dc.subject.meshLiver - Cytology - Metabolism - Pathologyen_US
dc.subject.meshLiver Cirrhosis, Experimental - Chemically Induceden_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Proteins - Genetics - Metabolismen_US
dc.subject.meshNitrates - Metabolismen_US
dc.subject.meshNitrites - Metabolismen_US
dc.subject.meshProtein Isoforms - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReceptor Activity-Modifying Protein 1en_US
dc.subject.meshReceptor Activity-Modifying Protein 2en_US
dc.subject.meshReceptor Activity-Modifying Protein 3en_US
dc.subject.meshReceptor Activity-Modifying Proteinsen_US
dc.subject.meshReceptors, Calcitonin - Genetics - Metabolismen_US
dc.subject.meshRenin - Blooden_US
dc.titleThe gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl4-induced rat liver cirrhosisen_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.emailFan, ST:stfan@hku.hken_US
dc.identifier.emailLuk, JMC:jmluk@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.identifier.authorityFan, ST=rp00355en_US
dc.identifier.authorityLuk, JMC=rp00349en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.regpep.2006.04.006en_US
dc.identifier.pmid16713642-
dc.identifier.scopuseid_2-s2.0-33745139817en_US
dc.identifier.hkuros116843-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745139817&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume135en_US
dc.identifier.issue1-2en_US
dc.identifier.spage69en_US
dc.identifier.epage77en_US
dc.identifier.isiWOS:000238810500011-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridHwang, ISS=7201615103en_US
dc.identifier.scopusauthoridTang, F=7201979770en_US
dc.identifier.scopusauthoridLeung, PP=7401749062en_US
dc.identifier.scopusauthoridLi, YY=49763596700en_US
dc.identifier.scopusauthoridFan, ST=7402678224en_US
dc.identifier.scopusauthoridLuk, JMC=7006777791en_US

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