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Article: Emerging role of cyclic ADP-ribose (cADPR) in smooth muscle

TitleEmerging role of cyclic ADP-ribose (cADPR) in smooth muscle
Authors
Issue Date2005
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmthera
Citation
Pharmacology And Therapeutics, 2005, v. 105 n. 2, p. 189-207 How to Cite?
AbstractCyclic adenosine diphosphate ribose (cADPR) is a naturally occurring cyclic nucleotide and represents a novel class of endogenous Ca2+ messengers implicated in the regulation of the gating properties of ryanodine receptors (RyRs). This action of cADPR occurs independently from the inositol-1,4,5-trisphosphate (IP3) receptor. The regulation of intracellular Ca2+ release is a fundamental element of cellular Ca2+ homeostasis since a number of smooth muscle functions (tone, proliferation, apoptosis, and gene expression) are modulated by intracellular Ca2+ concentration ([Ca2+]i). There has been a surge in the efforts aimed at understanding the mechanisms of cADPR-mediated Ca2+ mobilization and its impact on smooth muscle function. This review summarizes the proposed roles of cADPR in the regulation of smooth muscle tone. © 2004 Published by Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/171728
ISSN
2015 Impact Factor: 11.0
2015 SCImago Journal Rankings: 4.090
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBai, Nen_US
dc.contributor.authorLee, HCen_US
dc.contributor.authorLaher, Ien_US
dc.date.accessioned2012-10-30T06:16:39Z-
dc.date.available2012-10-30T06:16:39Z-
dc.date.issued2005en_US
dc.identifier.citationPharmacology And Therapeutics, 2005, v. 105 n. 2, p. 189-207en_US
dc.identifier.issn0163-7258en_US
dc.identifier.urihttp://hdl.handle.net/10722/171728-
dc.description.abstractCyclic adenosine diphosphate ribose (cADPR) is a naturally occurring cyclic nucleotide and represents a novel class of endogenous Ca2+ messengers implicated in the regulation of the gating properties of ryanodine receptors (RyRs). This action of cADPR occurs independently from the inositol-1,4,5-trisphosphate (IP3) receptor. The regulation of intracellular Ca2+ release is a fundamental element of cellular Ca2+ homeostasis since a number of smooth muscle functions (tone, proliferation, apoptosis, and gene expression) are modulated by intracellular Ca2+ concentration ([Ca2+]i). There has been a surge in the efforts aimed at understanding the mechanisms of cADPR-mediated Ca2+ mobilization and its impact on smooth muscle function. This review summarizes the proposed roles of cADPR in the regulation of smooth muscle tone. © 2004 Published by Elsevier Inc.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmtheraen_US
dc.relation.ispartofPharmacology and Therapeuticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium - Metabolismen_US
dc.subject.meshCyclic Adp-Ribose - Physiologyen_US
dc.subject.meshMuscle, Smooth - Enzymologyen_US
dc.subject.meshSignal Transductionen_US
dc.titleEmerging role of cyclic ADP-ribose (cADPR) in smooth muscleen_US
dc.typeArticleen_US
dc.identifier.emailLee, HC:leehc@hku.hken_US
dc.identifier.authorityLee, HC=rp00545en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.pharmthera.2004.10.005en_US
dc.identifier.pmid15670626-
dc.identifier.scopuseid_2-s2.0-12744271567en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-12744271567&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume105en_US
dc.identifier.issue2en_US
dc.identifier.spage189en_US
dc.identifier.epage207en_US
dc.identifier.isiWOS:000226930900007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridBai, N=9243610600en_US
dc.identifier.scopusauthoridLee, HC=26642959100en_US
dc.identifier.scopusauthoridLaher, I=7005431686en_US

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