File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Co-regulation of mucosal prostanoids and substance P by indomethacin in rat stomachs

TitleCo-regulation of mucosal prostanoids and substance P by indomethacin in rat stomachs
Authors
Issue Date1997
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 1997, v. 60 n. 19, p. PL-277-PL-281 How to Cite?
AbstractThe present investigation examined the correlation between the regulation of mucosal prostaglandin (PG) biosynthesis and the release of the neuropeptide substance P (SP) in rat stomachs by indomethacin, a cyclooxygenase inhibitor. When given subcutaneously at the dose of 5 mg/kg, indomethacin reduced mucosal biosynthesis of PGE 2 and concurrently lowered mucosal SP level. The inter-relationship between mucosal generation of PG and SP was further demonstrated by using [D-Pro 2, D-Trp 7,9]-SP, which also inhibited PGE 2 production besides its suppression on SP release. Co-administration of either arachidonic acid, the PGE 2 precursor, or SP reversed the inhibitory actions of indomethacin and [D-Pro 2, D-Trp 7,9]-SP, respectively, on mucosal levels of PGE 2 and SP. Our findings suggest that indomethacin, aside from its depletion of endogenous PG, also exerts a secondary action in regulating the release of SP, which is mediated indirectly through PG in the gastric mucosa. These actions may play a role in the modulation of gastric mucosal integrity.
Persistent Identifierhttp://hdl.handle.net/10722/171719
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
References

 

DC FieldValueLanguage
dc.contributor.authorKo, JKSen_US
dc.contributor.authorTang, Fen_US
dc.contributor.authorCho, CHen_US
dc.date.accessioned2012-10-30T06:16:36Z-
dc.date.available2012-10-30T06:16:36Z-
dc.date.issued1997en_US
dc.identifier.citationLife Sciences, 1997, v. 60 n. 19, p. PL-277-PL-281en_US
dc.identifier.issn0024-3205en_US
dc.identifier.urihttp://hdl.handle.net/10722/171719-
dc.description.abstractThe present investigation examined the correlation between the regulation of mucosal prostaglandin (PG) biosynthesis and the release of the neuropeptide substance P (SP) in rat stomachs by indomethacin, a cyclooxygenase inhibitor. When given subcutaneously at the dose of 5 mg/kg, indomethacin reduced mucosal biosynthesis of PGE 2 and concurrently lowered mucosal SP level. The inter-relationship between mucosal generation of PG and SP was further demonstrated by using [D-Pro 2, D-Trp 7,9]-SP, which also inhibited PGE 2 production besides its suppression on SP release. Co-administration of either arachidonic acid, the PGE 2 precursor, or SP reversed the inhibitory actions of indomethacin and [D-Pro 2, D-Trp 7,9]-SP, respectively, on mucosal levels of PGE 2 and SP. Our findings suggest that indomethacin, aside from its depletion of endogenous PG, also exerts a secondary action in regulating the release of SP, which is mediated indirectly through PG in the gastric mucosa. These actions may play a role in the modulation of gastric mucosal integrity.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_US
dc.relation.ispartofLife Sciencesen_US
dc.rightsLife Sciences. Copyright © Elsevier Inc.-
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal - Pharmacologyen_US
dc.subject.meshArachidonic Acid - Pharmacologyen_US
dc.subject.meshDinoprostone - Biosynthesisen_US
dc.subject.meshGastric Mucosa - Drug Effects - Metabolismen_US
dc.subject.meshIndomethacin - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSubstance P - Analogs & Derivatives - Metabolism - Pharmacologyen_US
dc.titleCo-regulation of mucosal prostanoids and substance P by indomethacin in rat stomachsen_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0024-3205(97)00117-3-
dc.identifier.pmid9129130-
dc.identifier.scopuseid_2-s2.0-0342275251en_US
dc.identifier.hkuros26071-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0342275251&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume60en_US
dc.identifier.issue19en_US
dc.identifier.spagePLen_US
dc.identifier.epage277en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKo, JKS=7402678571en_US
dc.identifier.scopusauthoridTang, F=7201979770en_US
dc.identifier.scopusauthoridCho, CH=14067000400en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats