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Article: The striatal GABA-ergic neurons expressing substance P receptors in the basal ganglia of mice

TitleThe striatal GABA-ergic neurons expressing substance P receptors in the basal ganglia of mice
Authors
Issue Date2003
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscience
Citation
Neuroscience, 2003, v. 119 n. 4, p. 919-925 How to Cite?
AbstractBy using a double immunofluorescence, we have examined the distribution of striatal GABAergic neurons that expressed substance P receptor (SPR) in the basal ganglia of adult C57 mice. The distribution of GABA-immunoreactive neurons completely or partially overlapped with that of SPR-immunoreactive neurons in the striatum (i.e. the caudate-putamen), globus pallidus, ventral pallidum, and nucleus accumbens. Neurons showing both GABA- and SPR-immunoreactivities were, however, predominantly found in the caudate-putamen, and most of them were characterized by their large-sized aspiny neuronal profile. Semi-quantification indicated that only about 13% of the total GABA-immunoreactive neurons (including large and medium-sized) displayed SPR-immunoreactivity, and these double-labeled neurons constituted about 31% of the total SPR-immunoreactive cells in the striatum. Neurons double-labeled with GABA- and SPR-immunoreactivities were hardly detected in other aforementioned regions of the basal ganglia. In addition, double immunofluorescence also showed co-localization of SPR- with glutamic acid decarboxylase-immunoreactivity, but not with parvalbumin-immunoreactivity, in the striatal neurons. Taken together with previous reports, the present study has suggested that a sub-population of striatal GABA-ergic neurons, most possibly GABA-ergic interneurons, may also receive direct physiological modulation by tachykinins through SPR in the basal ganglia of mammals. © 2003 IBRO. Published by Elsevier Science Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/171714
ISSN
2015 Impact Factor: 3.231
2015 SCImago Journal Rankings: 1.768
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, LWen_US
dc.contributor.authorCao, Ren_US
dc.contributor.authorLiu, HLen_US
dc.contributor.authorJu, Gen_US
dc.contributor.authorChan, YSen_US
dc.date.accessioned2012-10-30T06:16:33Z-
dc.date.available2012-10-30T06:16:33Z-
dc.date.issued2003en_US
dc.identifier.citationNeuroscience, 2003, v. 119 n. 4, p. 919-925en_US
dc.identifier.issn0306-4522en_US
dc.identifier.urihttp://hdl.handle.net/10722/171714-
dc.description.abstractBy using a double immunofluorescence, we have examined the distribution of striatal GABAergic neurons that expressed substance P receptor (SPR) in the basal ganglia of adult C57 mice. The distribution of GABA-immunoreactive neurons completely or partially overlapped with that of SPR-immunoreactive neurons in the striatum (i.e. the caudate-putamen), globus pallidus, ventral pallidum, and nucleus accumbens. Neurons showing both GABA- and SPR-immunoreactivities were, however, predominantly found in the caudate-putamen, and most of them were characterized by their large-sized aspiny neuronal profile. Semi-quantification indicated that only about 13% of the total GABA-immunoreactive neurons (including large and medium-sized) displayed SPR-immunoreactivity, and these double-labeled neurons constituted about 31% of the total SPR-immunoreactive cells in the striatum. Neurons double-labeled with GABA- and SPR-immunoreactivities were hardly detected in other aforementioned regions of the basal ganglia. In addition, double immunofluorescence also showed co-localization of SPR- with glutamic acid decarboxylase-immunoreactivity, but not with parvalbumin-immunoreactivity, in the striatal neurons. Taken together with previous reports, the present study has suggested that a sub-population of striatal GABA-ergic neurons, most possibly GABA-ergic interneurons, may also receive direct physiological modulation by tachykinins through SPR in the basal ganglia of mammals. © 2003 IBRO. Published by Elsevier Science Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscienceen_US
dc.relation.ispartofNeuroscienceen_US
dc.rightsNeuroscience. Copyright © Elsevier BV.-
dc.subject.meshAnimalsen_US
dc.subject.meshCorpus Striatum - Cytology - Metabolismen_US
dc.subject.meshDendrites - Metabolism - Ultrastructureen_US
dc.subject.meshGlutamate Decarboxylase - Metabolismen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57blen_US
dc.subject.meshNeostriatum - Cytology - Metabolismen_US
dc.subject.meshNeurons - Cytology - Metabolismen_US
dc.subject.meshParvalbumins - Metabolismen_US
dc.subject.meshReceptors, Neurokinin-1 - Metabolismen_US
dc.subject.meshSubstance P - Metabolismen_US
dc.subject.meshGamma-Aminobutyric Acid - Metabolismen_US
dc.titleThe striatal GABA-ergic neurons expressing substance P receptors in the basal ganglia of miceen_US
dc.typeArticleen_US
dc.identifier.emailChan, YS:yschan@hkucc.hku.hken_US
dc.identifier.authorityChan, YS=rp00318en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0306-4522(03)00223-9en_US
dc.identifier.pmid12831852-
dc.identifier.scopuseid_2-s2.0-0038094517en_US
dc.identifier.hkuros81394-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038094517&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume119en_US
dc.identifier.issue4en_US
dc.identifier.spage919en_US
dc.identifier.epage925en_US
dc.identifier.isiWOS:000184107100002-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridChen, LW=15821717100en_US
dc.identifier.scopusauthoridCao, R=34567948400en_US
dc.identifier.scopusauthoridLiu, HL=36066506000en_US
dc.identifier.scopusauthoridJu, G=26642903700en_US
dc.identifier.scopusauthoridChan, YS=7403676627en_US

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