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Article: The effects of melatonin and Ginkgo biloba extract on memory loss and choline acetyltransferase activities in the brain of rats infused intracerebroventricularly with β-amyloid 1-40

TitleThe effects of melatonin and Ginkgo biloba extract on memory loss and choline acetyltransferase activities in the brain of rats infused intracerebroventricularly with β-amyloid 1-40
Authors
Issue Date2002
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 2002, v. 71 n. 22, p. 2625-2631 How to Cite?
AbstractIntraventricular infusion of rats with β-amyloid for 14 days resulted in memory deficit in the water maze as well as decreases in choline acetyltransferase activities and somatostatin levels in the cerebral cortex and hippocampus. These changes were not altered by daily intraperitoneal injection of 20 mg/Kg melatonin. Orally administered Ginkgo biloba extract, however, partially reversed the memory deficit and the decrease in choline actyltransferase activities in the hippocampus. The latter treatment failed to reverse the decrease in somatostatin levels. The results indicate that orally administered Ginkgo biloba extract can protect the brain against β-amyloid from changes leading to memory deficit through its effect on the cholinergic system. © 2002 Elsevier Science Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/171710
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, Fen_US
dc.contributor.authorNag, Sen_US
dc.contributor.authorShiu, SYWen_US
dc.contributor.authorPang, SFen_US
dc.date.accessioned2012-10-30T06:16:32Z-
dc.date.available2012-10-30T06:16:32Z-
dc.date.issued2002en_US
dc.identifier.citationLife Sciences, 2002, v. 71 n. 22, p. 2625-2631en_US
dc.identifier.issn0024-3205en_US
dc.identifier.urihttp://hdl.handle.net/10722/171710-
dc.description.abstractIntraventricular infusion of rats with β-amyloid for 14 days resulted in memory deficit in the water maze as well as decreases in choline acetyltransferase activities and somatostatin levels in the cerebral cortex and hippocampus. These changes were not altered by daily intraperitoneal injection of 20 mg/Kg melatonin. Orally administered Ginkgo biloba extract, however, partially reversed the memory deficit and the decrease in choline actyltransferase activities in the hippocampus. The latter treatment failed to reverse the decrease in somatostatin levels. The results indicate that orally administered Ginkgo biloba extract can protect the brain against β-amyloid from changes leading to memory deficit through its effect on the cholinergic system. © 2002 Elsevier Science Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_US
dc.relation.ispartofLife Sciencesen_US
dc.rightsLife Sciences. Copyright © Elsevier Inc.-
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAmyloid Beta-Peptides - Administration & Dosage - Toxicityen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidants - Administration & Dosage - Pharmacologyen_US
dc.subject.meshBrain - Drug Effects - Enzymologyen_US
dc.subject.meshCerebral Cortex - Drug Effects - Metabolismen_US
dc.subject.meshCholine O-Acetyltransferase - Metabolismen_US
dc.subject.meshGinkgo Bilobaen_US
dc.subject.meshHippocampus - Drug Effects - Metabolismen_US
dc.subject.meshInjections, Intraperitonealen_US
dc.subject.meshInjections, Intraventricularen_US
dc.subject.meshMaleen_US
dc.subject.meshMaze Learning - Drug Effectsen_US
dc.subject.meshMelatonin - Administration & Dosage - Pharmacologyen_US
dc.subject.meshMemory Disorders - Chemically Induced - Prevention & Controlen_US
dc.subject.meshPeptide Fragments - Administration & Dosage - Toxicityen_US
dc.subject.meshPlant Extracts - Administration & Dosage - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSomatostatin - Metabolismen_US
dc.titleThe effects of melatonin and Ginkgo biloba extract on memory loss and choline acetyltransferase activities in the brain of rats infused intracerebroventricularly with β-amyloid 1-40en_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.emailShiu, SYW:sywshiu@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.identifier.authorityShiu, SYW=rp00384en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0024-3205(02)02105-7en_US
dc.identifier.pmid12354581en_US
dc.identifier.scopuseid_2-s2.0-0037131557en_US
dc.identifier.hkuros72033-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037131557&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume71en_US
dc.identifier.issue22en_US
dc.identifier.spage2625en_US
dc.identifier.epage2631en_US
dc.identifier.isiWOS:000178589300005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTang, F=7201979770en_US
dc.identifier.scopusauthoridNag, S=7103093193en_US
dc.identifier.scopusauthoridShiu, SYW=7005550655en_US
dc.identifier.scopusauthoridPang, SF=7402528719en_US

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