File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Cholinergic neurons expressing substance P receptor (NK1) in the basal forebrain of the rat: A double immunocytochemical study

TitleCholinergic neurons expressing substance P receptor (NK1) in the basal forebrain of the rat: A double immunocytochemical study
Authors
Issue Date2001
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2001, v. 904 n. 1, p. 161-166 How to Cite?
AbstractCholinergic neurons expressing substance P receptor (SPR, NK1) were examined in the rat brain using double immunofluorescence. The distribution of SPR-like immunoreactive (SPR-LI) neurons completely overlapped with that of choline acetyltransferase (ChAT)-LI neurons in the medial septal nucleus, the nucleus of diagonal band of Broca, the magnocellular preoptic nucleus, the substantia innominata of basal forebrain, the caudate-putamen, and the ventral pallidum of the basal ganglia. In the mesopontine tegmentum and the cranial motor nuclei of the brainstem, the distribution of SPR-LI and ChAT-LI neurons was partially overlapping. Neurons showing both SPR-like and ChAT-like immunoreactivities, however, were predominantly found above basal forebrain regions and 82-90% of these ChAT-LI neurons displayed SPR-like immunoreactivity, in addition to the confirmatory observation that 100% of the ChAT-LI neurons exhibit SPR-like immunoreactivity in the basal ganglia. In contrast, neurons double-labeled for SPR-like and ChAT-like immunoreactivities were hardly detected in aforementioned regions of the brainstem. The present study has provided morphological evidence for direct physiological modulation of cholinergic neurons by tachykinins through substance P receptor in the basal forebrain of the rat. © 2001 Elsevier Science B.V.
Persistent Identifierhttp://hdl.handle.net/10722/171698
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, LWen_US
dc.contributor.authorWei, LCen_US
dc.contributor.authorLiu, HLen_US
dc.contributor.authorQiu, Yen_US
dc.contributor.authorChan, YSen_US
dc.date.accessioned2012-10-30T06:16:26Z-
dc.date.available2012-10-30T06:16:26Z-
dc.date.issued2001en_US
dc.identifier.citationBrain Research, 2001, v. 904 n. 1, p. 161-166en_US
dc.identifier.issn0006-8993en_US
dc.identifier.urihttp://hdl.handle.net/10722/171698-
dc.description.abstractCholinergic neurons expressing substance P receptor (SPR, NK1) were examined in the rat brain using double immunofluorescence. The distribution of SPR-like immunoreactive (SPR-LI) neurons completely overlapped with that of choline acetyltransferase (ChAT)-LI neurons in the medial septal nucleus, the nucleus of diagonal band of Broca, the magnocellular preoptic nucleus, the substantia innominata of basal forebrain, the caudate-putamen, and the ventral pallidum of the basal ganglia. In the mesopontine tegmentum and the cranial motor nuclei of the brainstem, the distribution of SPR-LI and ChAT-LI neurons was partially overlapping. Neurons showing both SPR-like and ChAT-like immunoreactivities, however, were predominantly found above basal forebrain regions and 82-90% of these ChAT-LI neurons displayed SPR-like immunoreactivity, in addition to the confirmatory observation that 100% of the ChAT-LI neurons exhibit SPR-like immunoreactivity in the basal ganglia. In contrast, neurons double-labeled for SPR-like and ChAT-like immunoreactivities were hardly detected in aforementioned regions of the brainstem. The present study has provided morphological evidence for direct physiological modulation of cholinergic neurons by tachykinins through substance P receptor in the basal forebrain of the rat. © 2001 Elsevier Science B.V.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_US
dc.relation.ispartofBrain Researchen_US
dc.rightsBrain Research. Copyright © Elsevier BV.-
dc.subject.meshAcetylcholine - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBasal Nucleus Of Meynert - Cytology - Metabolismen_US
dc.subject.meshCell Counten_US
dc.subject.meshCholinergic Fibers - Metabolism - Ultrastructureen_US
dc.subject.meshFluorescent Antibody Techniqueen_US
dc.subject.meshMaleen_US
dc.subject.meshNeurons - Cytology - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshReceptors, Neurokinin-1 - Metabolismen_US
dc.subject.meshSubstance P - Metabolismen_US
dc.titleCholinergic neurons expressing substance P receptor (NK1) in the basal forebrain of the rat: A double immunocytochemical studyen_US
dc.typeArticleen_US
dc.identifier.emailChan, YS:yschan@hkucc.hku.hken_US
dc.identifier.authorityChan, YS=rp00318en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0006-8993(01)02460-Xen_US
dc.identifier.pmid11516425-
dc.identifier.scopuseid_2-s2.0-0035876352en_US
dc.identifier.hkuros60103-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035876352&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume904en_US
dc.identifier.issue1en_US
dc.identifier.spage161en_US
dc.identifier.epage166en_US
dc.identifier.isiWOS:000169588900020-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridChen, LW=15821717100en_US
dc.identifier.scopusauthoridWei, LC=7402951429en_US
dc.identifier.scopusauthoridLiu, HL=36066506000en_US
dc.identifier.scopusauthoridQiu, Y=7403279738en_US
dc.identifier.scopusauthoridChan, YS=7403676627en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats