File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Inhibition of androgen-sensitive LNCaP prostate cancer growth in vivo by melatonin: Association of antiproliferative action of the pineal hormone with mt1 receptor protein expression

TitleInhibition of androgen-sensitive LNCaP prostate cancer growth in vivo by melatonin: Association of antiproliferative action of the pineal hormone with mt1 receptor protein expression
Authors
Issue Date2001
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34304
Citation
Prostate, 2001, v. 46 n. 1, p. 52-61 How to Cite?
AbstractBACKGROUND. Potential involvement of the mt1 receptor in the antiproliferative action of melatonin on androgen-sensitive LNCaP cells, and melatonin-induced modulation of androgen-insensitive PC-3 cell growth, have been reported in vitro. The effects of melatonin on prostate cancer cell proliferation and their association with mt1 receptor expression were investigated in athymic nude mice xenograft models of LNCaP and PC-3 cells. METHODS. Daily saline or melatonin (4 μg/g body weight) was given to nude mice before or after tumor cell inoculation. Tumor volume was measured periodically, and expression of PCNA, cyclin A, PSA, and mt1 receptor was assessed by immunohisto(cyto)chemistry and/or Western blotting. RESULTS. Melatonin inhibited the growth of LNCaP tumors, without affecting the growth of PC-3 xenografts, in nude mice. It induced significant decreases in the expression of PCNA, cyclin A, and PSA in LNCaP tumors. Expression of mt1 receptor protein was demonstrated in LNCaP cells, but not in PC-3 cells, both in vivo and in vitro. CONCLUSIONS. The antiproliferative action of melatonin on LNCaP tumor growth was demonstrated in vivo, and its association with mt1 receptor protein expression suggests the potential involvement of the receptor in the antitumor activity of the pineal gland hormone. © 2001 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/171693
ISSN
2015 Impact Factor: 3.778
2015 SCImago Journal Rankings: 1.477
References

 

DC FieldValueLanguage
dc.contributor.authorXi, SCen_US
dc.contributor.authorSiu, SWFen_US
dc.contributor.authorFong, SWen_US
dc.contributor.authorShiu, SYWen_US
dc.date.accessioned2012-10-30T06:16:24Z-
dc.date.available2012-10-30T06:16:24Z-
dc.date.issued2001en_US
dc.identifier.citationProstate, 2001, v. 46 n. 1, p. 52-61en_US
dc.identifier.issn0270-4137en_US
dc.identifier.urihttp://hdl.handle.net/10722/171693-
dc.description.abstractBACKGROUND. Potential involvement of the mt1 receptor in the antiproliferative action of melatonin on androgen-sensitive LNCaP cells, and melatonin-induced modulation of androgen-insensitive PC-3 cell growth, have been reported in vitro. The effects of melatonin on prostate cancer cell proliferation and their association with mt1 receptor expression were investigated in athymic nude mice xenograft models of LNCaP and PC-3 cells. METHODS. Daily saline or melatonin (4 μg/g body weight) was given to nude mice before or after tumor cell inoculation. Tumor volume was measured periodically, and expression of PCNA, cyclin A, PSA, and mt1 receptor was assessed by immunohisto(cyto)chemistry and/or Western blotting. RESULTS. Melatonin inhibited the growth of LNCaP tumors, without affecting the growth of PC-3 xenografts, in nude mice. It induced significant decreases in the expression of PCNA, cyclin A, and PSA in LNCaP tumors. Expression of mt1 receptor protein was demonstrated in LNCaP cells, but not in PC-3 cells, both in vivo and in vitro. CONCLUSIONS. The antiproliferative action of melatonin on LNCaP tumor growth was demonstrated in vivo, and its association with mt1 receptor protein expression suggests the potential involvement of the receptor in the antitumor activity of the pineal gland hormone. © 2001 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34304en_US
dc.relation.ispartofProstateen_US
dc.rightsThe Prostate. Copyright © John Wiley & Sons, Inc.-
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Monoclonalen_US
dc.subject.meshAntioxidants - Pharmacology - Therapeutic Useen_US
dc.subject.meshApoptosis - Drug Effectsen_US
dc.subject.meshBlotting, Westernen_US
dc.subject.meshCell Division - Drug Effectsen_US
dc.subject.meshCyclin A - Analysisen_US
dc.subject.meshGene Expression Regulation, Neoplasticen_US
dc.subject.meshHumansen_US
dc.subject.meshImage Processing, Computer-Assisteden_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshIn Situ Nick-End Labelingen_US
dc.subject.meshMaleen_US
dc.subject.meshMelatonin - Pharmacology - Therapeutic Useen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Balb Cen_US
dc.subject.meshMice, Nudeen_US
dc.subject.meshProliferating Cell Nuclear Antigen - Analysisen_US
dc.subject.meshProstate-Specific Antigen - Analysisen_US
dc.subject.meshProstatic Neoplasms - Drug Therapy - Pathologyen_US
dc.subject.meshReceptors, Cell Surface - Analysisen_US
dc.subject.meshReceptors, Cytoplasmic And Nuclear - Analysisen_US
dc.subject.meshReceptors, Melatoninen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleInhibition of androgen-sensitive LNCaP prostate cancer growth in vivo by melatonin: Association of antiproliferative action of the pineal hormone with mt1 receptor protein expressionen_US
dc.typeArticleen_US
dc.identifier.emailShiu, SYW:sywshiu@hkucc.hku.hken_US
dc.identifier.emailFong, SW: swanfong@graduate.hku.hk-
dc.identifier.authorityShiu, SYW=rp00384en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/1097-0045(200101)46:1<52::AID-PROS1008>3.0.CO;2-Zen_US
dc.identifier.pmid11170132-
dc.identifier.scopuseid_2-s2.0-0035138150en_US
dc.identifier.hkuros58147-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035138150&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume46en_US
dc.identifier.issue1en_US
dc.identifier.spage52en_US
dc.identifier.epage61en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridXi, SC=35944696100en_US
dc.identifier.scopusauthoridSiu, SWF=36905820000en_US
dc.identifier.scopusauthoridFong, SW=7102256321en_US
dc.identifier.scopusauthoridShiu, SYW=7005550655en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats