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Article: Melatonin receptors and melatonin inhibition of duck salt gland secretion

TitleMelatonin receptors and melatonin inhibition of duck salt gland secretion
Authors
Issue Date1999
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygcen
Citation
General And Comparative Endocrinology, 1999, v. 116 n. 2, p. 229-240 How to Cite?
AbstractMost of the NaCl ingested by marine birds is reabsorbed from renal filtrate and excreted by the cephalic salt glands as a hypertonic NaCl secretion (SGS). Ducks have salt glands and their kidney cells have melatonin receptors. Melatonin affects glomerular filtration rate and tubular uptake of sodium (Na+) in mammals. We hypothesized that (1) duck salt glands also have melatonin receptors and (2) melatonin affects extrarenal Na+ secretion. Both hypotheses were accepted because putative melatonin receptors were identified by 2[125I]iodomelatonin binding in salt glands of Pekin ducks, Anas platyrhynchos, and because melatonin inhibited SGS in these ducks. Saline ingestion increased B(max), but not K(d), of salt gland receptors. The duration of NaCl infusion needed to stimulate SGS was positively related with preinfusion plasma melatonin concentration ([mel](pl)). Raising [mel](pl) prior to NaCl infusion further delayed onset of secretion and decreased secretion rate and concentration without affecting plasma volume and Na+ concentration. Abrupt increase in [mel](pl) during SGS immediately decreased the rate by 43%. Secretion rate remained lower than the control rate during the subsequent hour; secretion concentration was not affected. This is the first report of putative melatonin binding sites in avian salt glands. Melatonin slowed the onset of NaCl-induced salt gland secretion and decreased its rate.
Persistent Identifierhttp://hdl.handle.net/10722/171663
ISSN
2015 Impact Factor: 2.667
2015 SCImago Journal Rankings: 1.245
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChing, ACTen_US
dc.contributor.authorHughes, MRen_US
dc.contributor.authorPoon, AMSen_US
dc.contributor.authorPang, SFen_US
dc.date.accessioned2012-10-30T06:16:14Z-
dc.date.available2012-10-30T06:16:14Z-
dc.date.issued1999en_US
dc.identifier.citationGeneral And Comparative Endocrinology, 1999, v. 116 n. 2, p. 229-240en_US
dc.identifier.issn0016-6480en_US
dc.identifier.urihttp://hdl.handle.net/10722/171663-
dc.description.abstractMost of the NaCl ingested by marine birds is reabsorbed from renal filtrate and excreted by the cephalic salt glands as a hypertonic NaCl secretion (SGS). Ducks have salt glands and their kidney cells have melatonin receptors. Melatonin affects glomerular filtration rate and tubular uptake of sodium (Na+) in mammals. We hypothesized that (1) duck salt glands also have melatonin receptors and (2) melatonin affects extrarenal Na+ secretion. Both hypotheses were accepted because putative melatonin receptors were identified by 2[125I]iodomelatonin binding in salt glands of Pekin ducks, Anas platyrhynchos, and because melatonin inhibited SGS in these ducks. Saline ingestion increased B(max), but not K(d), of salt gland receptors. The duration of NaCl infusion needed to stimulate SGS was positively related with preinfusion plasma melatonin concentration ([mel](pl)). Raising [mel](pl) prior to NaCl infusion further delayed onset of secretion and decreased secretion rate and concentration without affecting plasma volume and Na+ concentration. Abrupt increase in [mel](pl) during SGS immediately decreased the rate by 43%. Secretion rate remained lower than the control rate during the subsequent hour; secretion concentration was not affected. This is the first report of putative melatonin binding sites in avian salt glands. Melatonin slowed the onset of NaCl-induced salt gland secretion and decreased its rate.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygcenen_US
dc.relation.ispartofGeneral and Comparative Endocrinologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDucks - Physiologyen_US
dc.subject.meshIodine Radioisotopesen_US
dc.subject.meshMaleen_US
dc.subject.meshMelatonin - Blood - Pharmacologyen_US
dc.subject.meshOsmolar Concentrationen_US
dc.subject.meshReceptors, Cell Surface - Metabolism - Physiologyen_US
dc.subject.meshReceptors, Cytoplasmic And Nuclear - Metabolism - Physiologyen_US
dc.subject.meshReceptors, Melatoninen_US
dc.subject.meshSalt Gland - Drug Effects - Metabolism - Secretionen_US
dc.subject.meshSodium Chloride - Administration & Dosage - Metabolismen_US
dc.titleMelatonin receptors and melatonin inhibition of duck salt gland secretionen_US
dc.typeArticleen_US
dc.identifier.emailPoon, AMS:amspoon@hkucc.hku.hken_US
dc.identifier.emailPang, SF: hrmypsf@hkucc.hku.hk-
dc.identifier.authorityPoon, AMS=rp00354en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1006/gcen.1999.7362en_US
dc.identifier.pmid10562453-
dc.identifier.scopuseid_2-s2.0-0032731708en_US
dc.identifier.hkuros53257-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032731708&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume116en_US
dc.identifier.issue2en_US
dc.identifier.spage229en_US
dc.identifier.epage240en_US
dc.identifier.isiWOS:000083924700009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChing, ACT=8128628400en_US
dc.identifier.scopusauthoridHughes, MR=7402467508en_US
dc.identifier.scopusauthoridPoon, AMS=7103068868en_US
dc.identifier.scopusauthoridPang, SF=7402528719en_US

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