File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Phrenic response to hypercapnia in the unanesthetized, decerebrate, newborn rat

TitlePhrenic response to hypercapnia in the unanesthetized, decerebrate, newborn rat
Authors
Issue Date1996
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/resphysiol
Citation
Respiration Physiology, 1996, v. 104 n. 1, p. 11-22 How to Cite?
AbstractWe developed a decerebrate, vagotomized, newborn rat preparation to investigate brainstem respiratory control mechanisms without the influence of anesthesia, supra-pontine structures, or vagally mediated feedback mechanisms. We measured the changes in phrenic nerve electrical activity in response to breathing 3% and 5% CO 2 in unanesthetized, vagotomized, decerebrate newborn rats from 0 to 10 days of age and compared them with the changes in anesthetized, vagotomized, newborn rats and adult, vagotomized, decerebrate or anesthetized animals. Phrenic nerve activity was irregular in the young newborn rats and became more regular between 7 and 10 days of age. TI and TI/Ttot increased with age but increasing age had no influence on the response to CO 2. The response to CO 2, was dominated by increases in phrenic amplitude, minute activity, and inspiratory slope with no change in timing variables. These responses are similar to those that have been reported previously in vagally intact animals, suggesting that vagal feedback contributes little to the response to hypercapnia in the newborn rat. In summary, decerebrate newborn rats consistently respond to hypercapnia by increasing inspiratory drive similar to conscious animals.
Persistent Identifierhttp://hdl.handle.net/10722/171633
ISSN
2001 Impact Factor: 2.197
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, Den_US
dc.contributor.authorHuang, Qen_US
dc.contributor.authorFung, MLen_US
dc.contributor.authorLi, Aen_US
dc.contributor.authorDarnall, RAen_US
dc.contributor.authorNattie, EEen_US
dc.contributor.authorSt John, WMen_US
dc.date.accessioned2012-10-30T06:16:04Z-
dc.date.available2012-10-30T06:16:04Z-
dc.date.issued1996en_US
dc.identifier.citationRespiration Physiology, 1996, v. 104 n. 1, p. 11-22en_US
dc.identifier.issn0034-5687en_US
dc.identifier.urihttp://hdl.handle.net/10722/171633-
dc.description.abstractWe developed a decerebrate, vagotomized, newborn rat preparation to investigate brainstem respiratory control mechanisms without the influence of anesthesia, supra-pontine structures, or vagally mediated feedback mechanisms. We measured the changes in phrenic nerve electrical activity in response to breathing 3% and 5% CO 2 in unanesthetized, vagotomized, decerebrate newborn rats from 0 to 10 days of age and compared them with the changes in anesthetized, vagotomized, newborn rats and adult, vagotomized, decerebrate or anesthetized animals. Phrenic nerve activity was irregular in the young newborn rats and became more regular between 7 and 10 days of age. TI and TI/Ttot increased with age but increasing age had no influence on the response to CO 2. The response to CO 2, was dominated by increases in phrenic amplitude, minute activity, and inspiratory slope with no change in timing variables. These responses are similar to those that have been reported previously in vagally intact animals, suggesting that vagal feedback contributes little to the response to hypercapnia in the newborn rat. In summary, decerebrate newborn rats consistently respond to hypercapnia by increasing inspiratory drive similar to conscious animals.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/resphysiolen_US
dc.relation.ispartofRespiration Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newborn - Physiologyen_US
dc.subject.meshDecerebrate Stateen_US
dc.subject.meshHypercapnia - Metabolismen_US
dc.subject.meshPhrenic Nerve - Physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshRespirationen_US
dc.titlePhrenic response to hypercapnia in the unanesthetized, decerebrate, newborn raten_US
dc.typeArticleen_US
dc.identifier.emailFung, ML:fungml@hkucc.hku.hken_US
dc.identifier.authorityFung, ML=rp00433en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0034-5687(95)00098-4en_US
dc.identifier.pmid8865377-
dc.identifier.scopuseid_2-s2.0-0030131013en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030131013&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume104en_US
dc.identifier.issue1en_US
dc.identifier.spage11en_US
dc.identifier.epage22en_US
dc.identifier.isiWOS:A1996VC01800002-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridZhou, D=7403394239en_US
dc.identifier.scopusauthoridHuang, Q=24393569700en_US
dc.identifier.scopusauthoridFung, ML=7101955092en_US
dc.identifier.scopusauthoridLi, A=7403292086en_US
dc.identifier.scopusauthoridDarnall, RA=7003629071en_US
dc.identifier.scopusauthoridNattie, EE=7005019384en_US
dc.identifier.scopusauthoridSt John, WM=36831054200en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats