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Article: Effects of kainic acid administered to the caudal ventrolateral medulla on arterial blood pressure in the spontaneously hypertensive and normotensive Wistar-Kyoto rats

TitleEffects of kainic acid administered to the caudal ventrolateral medulla on arterial blood pressure in the spontaneously hypertensive and normotensive Wistar-Kyoto rats
Authors
Issue Date1996
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 1996, v. 202 n. 3, p. 145-148 How to Cite?
AbstractTo compare the inhibitory influence of the caudal ventrolateral medulla (RVLM) on rostral ventrolateral medulla (RVLM) between spontaneously hypertensive (SH) and normotensive Wistar-Kyoto (WKY) rats, we studied the blood pressure responses to administration of kainic acid, an excitotoxic agent, to CVLM. Unilateral or bilateral administration of kainic acid led to an initial reduction in blood pressure in both types of rats. In SH rats, this was followed by a gradual and sustained presser response. This biphasic response in arterial blood pressure was observed in only one-third of the WKY rats. The elevation in blood pressure was significantly greater in SH than in WKY rats. The finding suggests that the tonic inhibitory influence from RVLM to RVLM may be greater in SH than in WKY rats.
Persistent Identifierhttp://hdl.handle.net/10722/171632
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, Zen_US
dc.contributor.authorChan, YSen_US
dc.contributor.authorWong, TMen_US
dc.date.accessioned2012-10-30T06:16:04Z-
dc.date.available2012-10-30T06:16:04Z-
dc.date.issued1996en_US
dc.identifier.citationNeuroscience Letters, 1996, v. 202 n. 3, p. 145-148en_US
dc.identifier.issn0304-3940en_US
dc.identifier.urihttp://hdl.handle.net/10722/171632-
dc.description.abstractTo compare the inhibitory influence of the caudal ventrolateral medulla (RVLM) on rostral ventrolateral medulla (RVLM) between spontaneously hypertensive (SH) and normotensive Wistar-Kyoto (WKY) rats, we studied the blood pressure responses to administration of kainic acid, an excitotoxic agent, to CVLM. Unilateral or bilateral administration of kainic acid led to an initial reduction in blood pressure in both types of rats. In SH rats, this was followed by a gradual and sustained presser response. This biphasic response in arterial blood pressure was observed in only one-third of the WKY rats. The elevation in blood pressure was significantly greater in SH than in WKY rats. The finding suggests that the tonic inhibitory influence from RVLM to RVLM may be greater in SH than in WKY rats.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.rightsNeuroscience Letters. Copyright © Elsevier Ireland Ltd.-
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Pressure - Drug Effectsen_US
dc.subject.meshElectrodes, Implanteden_US
dc.subject.meshExcitatory Amino Acid Agonists - Administration & Dosage - Pharmacologyen_US
dc.subject.meshKainic Acid - Administration & Dosage - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMedulla Oblongata - Anatomy & Histology - Physiologyen_US
dc.subject.meshMicroinjectionsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Shren_US
dc.subject.meshRats, Inbred Wkyen_US
dc.titleEffects of kainic acid administered to the caudal ventrolateral medulla on arterial blood pressure in the spontaneously hypertensive and normotensive Wistar-Kyoto ratsen_US
dc.typeArticleen_US
dc.identifier.emailChan, YS:yschan@hkucc.hku.hken_US
dc.identifier.authorityChan, YS=rp00318en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0304-3940(95)12226-5en_US
dc.identifier.pmid8848252-
dc.identifier.scopuseid_2-s2.0-0030068351en_US
dc.identifier.hkuros15430-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030068351&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume202en_US
dc.identifier.issue3en_US
dc.identifier.spage145en_US
dc.identifier.epage148en_US
dc.identifier.isiWOS:A1996TT17000002-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridYang, Z=16742980200en_US
dc.identifier.scopusauthoridChan, YS=7403676627en_US
dc.identifier.scopusauthoridWong, TM=7403531434en_US

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