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Article: The effect of haloperidol on met-enkaphalin, beta-endorphin, cholecystokinin and substance P in the pituitary, the hypothalamus and the striatum of rats during aging

TitleThe effect of haloperidol on met-enkaphalin, beta-endorphin, cholecystokinin and substance P in the pituitary, the hypothalamus and the striatum of rats during aging
Authors
Issue Date1995
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pnpbp
Citation
Progress In Neuro-Psychopharmacology And Biological Psychiatry, 1995, v. 19 n. 7, p. 1163-1175 How to Cite?
AbstractHaloperidol increased the Met-enk level in the striatum at all age groups. However, the Met-enk level was decreased in AL of young and middle-aged rats by the drug. Haloperidol elevated the β-end level in AL and CCK level in NIL in young rats only. The SP content in NIL was decreased by haloperidol in all age groups. With regard to the effect of aging, Met-enk level in AL of middle-aged rats was higher than that in young rats. The β-end level in AL also increased in old rats. Aging modified the haloperidol effect on β-end level in AL and CCK level in NIL as the effect was only observed in young rats. In addition, aging caused a blunted response of Met-enk level to haloperidol in the striatum but an increased response of SP content to haloperidol in the NIL.
Persistent Identifierhttp://hdl.handle.net/10722/171623
ISSN
2015 Impact Factor: 4.361
2015 SCImago Journal Rankings: 1.794
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, SMen_US
dc.contributor.authorTang, Fen_US
dc.date.accessioned2012-10-30T06:16:01Z-
dc.date.available2012-10-30T06:16:01Z-
dc.date.issued1995en_US
dc.identifier.citationProgress In Neuro-Psychopharmacology And Biological Psychiatry, 1995, v. 19 n. 7, p. 1163-1175en_US
dc.identifier.issn0278-5846en_US
dc.identifier.urihttp://hdl.handle.net/10722/171623-
dc.description.abstractHaloperidol increased the Met-enk level in the striatum at all age groups. However, the Met-enk level was decreased in AL of young and middle-aged rats by the drug. Haloperidol elevated the β-end level in AL and CCK level in NIL in young rats only. The SP content in NIL was decreased by haloperidol in all age groups. With regard to the effect of aging, Met-enk level in AL of middle-aged rats was higher than that in young rats. The β-end level in AL also increased in old rats. Aging modified the haloperidol effect on β-end level in AL and CCK level in NIL as the effect was only observed in young rats. In addition, aging caused a blunted response of Met-enk level to haloperidol in the striatum but an increased response of SP content to haloperidol in the NIL.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pnpbpen_US
dc.relation.ispartofProgress in Neuro-Psychopharmacology and Biological Psychiatryen_US
dc.rightsProgress in Neuro-Psychopharmacology & Biological Psychiatry. Copyright © Elsevier Inc.-
dc.subject.meshAging - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCholecystokinin - Drug Effectsen_US
dc.subject.meshCorpus Striatum - Drug Effectsen_US
dc.subject.meshEnkephalin, Methionine - Drug Effectsen_US
dc.subject.meshHaloperidol - Pharmacologyen_US
dc.subject.meshHypothalamus - Drug Effects - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshPituitary Gland - Drug Effects - Metabolismen_US
dc.subject.meshRadioimmunoassayen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSubstance P - Drug Effectsen_US
dc.subject.meshBeta-Endorphin - Drug Effectsen_US
dc.titleThe effect of haloperidol on met-enkaphalin, beta-endorphin, cholecystokinin and substance P in the pituitary, the hypothalamus and the striatum of rats during agingen_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.authorityTang, F=rp00327en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0278-5846(95)00234-0en_US
dc.identifier.pmid8787040-
dc.identifier.scopuseid_2-s2.0-0029416918en_US
dc.identifier.hkuros11678-
dc.identifier.volume19en_US
dc.identifier.issue7en_US
dc.identifier.spage1163en_US
dc.identifier.epage1175en_US
dc.identifier.isiWOS:A1995TJ18000005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLau, SM=16740565000en_US
dc.identifier.scopusauthoridTang, F=7201979770en_US

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