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Article: Involvement of pontile NMDA receptors in inspiratory termination in rat

TitleInvolvement of pontile NMDA receptors in inspiratory termination in rat
Authors
Issue Date1994
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/resphysiol
Citation
Respiration Physiology, 1994, v. 96 n. 2-3, p. 177-188 How to Cite?
AbstractWe evaluated the hypothesis that N-methyl-D-aspartate (NMDA) receptors in the rostral pons mediate the off-switch of inspiration in the adult rat. Experiments were performed on decerebrate, vagotomized, paralyzed and ventilated animals. Activity of phrenic nerve was recorded. Small volumes (10 nl) of NMDA antagonists, MK-801 and AP-5, or non-NMDA antagonists, CNQX and DNQX, were injected into the rostral pons. We found that injections of MK-801 reversibly increased the duration of neural inspiration (TI), and the increase was dose-dependent. Injections of AP-5 also increased TI. Injections of the DNQX and CNQX in these same loci resulted in no significant changes in the duration of neural inspiration, expiration or peak phrenic activity (PNA). However, injections of kainic acid (KA, 4.7 mM) in the loci increased TI and decreased PNA. We conclude that neurons regulating the off-switch mechanism are located in the rostral pons. Further, the binding of NMDA receptors in the rostral pons is involved in this off-switch mechanism.
Persistent Identifierhttp://hdl.handle.net/10722/171608
ISSN
2001 Impact Factor: 2.197
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFung, MLen_US
dc.contributor.authorWang, Wen_US
dc.contributor.authorSt John, WMen_US
dc.date.accessioned2012-10-30T06:15:57Z-
dc.date.available2012-10-30T06:15:57Z-
dc.date.issued1994en_US
dc.identifier.citationRespiration Physiology, 1994, v. 96 n. 2-3, p. 177-188en_US
dc.identifier.issn0034-5687en_US
dc.identifier.urihttp://hdl.handle.net/10722/171608-
dc.description.abstractWe evaluated the hypothesis that N-methyl-D-aspartate (NMDA) receptors in the rostral pons mediate the off-switch of inspiration in the adult rat. Experiments were performed on decerebrate, vagotomized, paralyzed and ventilated animals. Activity of phrenic nerve was recorded. Small volumes (10 nl) of NMDA antagonists, MK-801 and AP-5, or non-NMDA antagonists, CNQX and DNQX, were injected into the rostral pons. We found that injections of MK-801 reversibly increased the duration of neural inspiration (TI), and the increase was dose-dependent. Injections of AP-5 also increased TI. Injections of the DNQX and CNQX in these same loci resulted in no significant changes in the duration of neural inspiration, expiration or peak phrenic activity (PNA). However, injections of kainic acid (KA, 4.7 mM) in the loci increased TI and decreased PNA. We conclude that neurons regulating the off-switch mechanism are located in the rostral pons. Further, the binding of NMDA receptors in the rostral pons is involved in this off-switch mechanism.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/resphysiolen_US
dc.relation.ispartofRespiration Physiologyen_US
dc.subject.mesh2-Amino-5-Phosphonovalerate - Pharmacologyen_US
dc.subject.mesh6-Cyano-7-Nitroquinoxaline-2,3-Dioneen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDizocilpine Maleate - Pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshPons - Metabolismen_US
dc.subject.meshQuinoxalines - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReceptors, N-Methyl-D-Aspartate - Physiologyen_US
dc.subject.meshRespiration - Drug Effects - Physiologyen_US
dc.titleInvolvement of pontile NMDA receptors in inspiratory termination in raten_US
dc.typeArticleen_US
dc.identifier.emailFung, ML:fungml@hkucc.hku.hken_US
dc.identifier.authorityFung, ML=rp00433en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0034-5687(94)90125-2-
dc.identifier.pmid7914709en_US
dc.identifier.scopuseid_2-s2.0-0028281587en_US
dc.identifier.volume96en_US
dc.identifier.issue2-3en_US
dc.identifier.spage177en_US
dc.identifier.epage188en_US
dc.identifier.isiWOS:A1994NH83600006-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridFung, ML=7101955092en_US
dc.identifier.scopusauthoridWang, W=7501756233en_US
dc.identifier.scopusauthoridSt John, WM=36831054200en_US

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